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Twists, Knots, and Rings in Proteins
Open accessAbstract
In recent years an increasing number of miniproteins containing an amide-cyclized backbone have been discovered. The cyclotide family is the largest group of such proteins and is characterized by a circular protein backbone and six conserved cysteine residues linked by disulfide bonds in a tight core of the molecule. These form a cystine knot in which an embedded ring formed by two of the disulfide bonds and the connecting backbone segment is threaded by a third disulfide bond. In the current study we have undertaken high resolution structural analysis of two prototypic cyclotides, kalata B1 and cycloviolacin O1, to define the role of the conserved residues in the sequence. We provide the first comprehensive analysis of the topological features in this unique family of proteins, namely rings (a circular backbone), twists (a cis-peptide bond in the Möbius cyclotides) and knots (a knotted arrangement of the disulfide bonds).
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Cited by
Colgrave, M. L., & Craik, D. J. (2004) · Biochemistry · doi:10.1021/bi049711q · Cited by 580
Self-citationHepcidin Revisited, Disulfide Connectivity, Dynamics, and Structure
Jordan, J. B., Poppe, L., Haniu, M., Arvedson, T., Syed, R., Li, V., Kohno, H., Kim, H., Schnier, P. D., Harvey, T. S., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.017764 · Cited by 214
Metadata
- Authors
- Rosengren, K. J., Daly, N. L., Plan, M. R., Waine, C., & Craik, D. J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-03
- Volume
- 278
- Issue
- 10
- Pages
- 8606-8616
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2153726959
- Cited by
- 312
- References
- 0
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Rosengren, K. J., Daly, N. L., Plan, M. R., Waine, C., & Craik, D. J. (2003). Twists, Knots, and Rings in Proteins. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m211147200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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