The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
The Catabolism of Amino Acids to Long Chain and Complex Alcohols in Saccharomyces cerevisiae
Open accessAbstract
The catabolism of phenylalanine to 2-phenylethanol and of tryptophan to tryptophol were studied by (13)C NMR spectroscopy and gas chromatography-mass spectrometry. Phenylalanine and tryptophan are first deaminated (to 3-phenylpyruvate and 3-indolepyruvate, respectively) and then decarboxylated. This decarboxylation can be effected by any of Pdc1p, Pdc5p, Pdc6p, or Ydr380wp; Ydl080cp has no role in the catabolism of either amino acid. We also report that in leucine catabolism Ydr380wp is the minor decarboxylase. Hence, all amino acid catabolic pathways studied to date use a subtly different spectrum of decarboxylases from the five-membered family that comprises Pdc1p, Pdc5p, Pdc6p, Ydl080cp, and Ydr380wp. Using strains containing all possible combinations of mutations affecting the seven AAD genes (putative aryl alcohol dehydrogenases), five ADH genes, and SFA1, showed that the final step of amino acid catabolism (conversion of an aldehyde to a long chain or complex alcohol) can be accomplished by any one of the ethanol dehydrogenases (Adh1p, Adh2p, Adh3p, Adh4p, Adh5p) or by Sfa1p (formaldehyde dehydrogenase.)
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Self-citationAn Investigation of the Metabolism of Valine to Isobutyl Alcohol in Saccharomyces cerevisiae
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An Investigation of the Metabolism of Isoleucine to Active Amyl Alcohol in Saccharomyces cerevisiae
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Self-citationTranscriptional Induction by Aromatic Amino Acids in Saccharomyces cerevisiae
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Candida glabrata tryptophan‐based pigment production via the Ehrlich pathway
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Metadata
- Authors
- Dickinson, J. R., Salgado, L. E. J., & Hewlins, M. J. E.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-03
- Volume
- 278
- Issue
- 10
- Pages
- 8028-8034
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2124144946
- Cited by
- 375
- References
- 20
- FWCI
- 20.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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