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Cited by 375

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

The Catabolism of Amino Acids to Long Chain and Complex Alcohols in Saccharomyces cerevisiae

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Dickinson, J. Richard, Salgado, L. Eshantha J., Hewlins, Michael J.E.·2003·Journal of Biological Chemistry

Abstract

The catabolism of phenylalanine to 2-phenylethanol and of tryptophan to tryptophol were studied by (13)C NMR spectroscopy and gas chromatography-mass spectrometry. Phenylalanine and tryptophan are first deaminated (to 3-phenylpyruvate and 3-indolepyruvate, respectively) and then decarboxylated. This decarboxylation can be effected by any of Pdc1p, Pdc5p, Pdc6p, or Ydr380wp; Ydl080cp has no role in the catabolism of either amino acid. We also report that in leucine catabolism Ydr380wp is the minor decarboxylase. Hence, all amino acid catabolic pathways studied to date use a subtly different spectrum of decarboxylases from the five-membered family that comprises Pdc1p, Pdc5p, Pdc6p, Ydl080cp, and Ydr380wp. Using strains containing all possible combinations of mutations affecting the seven AAD genes (putative aryl alcohol dehydrogenases), five ADH genes, and SFA1, showed that the final step of amino acid catabolism (conversion of an aldehyde to a long chain or complex alcohol) can be accomplished by any one of the ethanol dehydrogenases (Adh1p, Adh2p, Adh3p, Adh4p, Adh5p) or by Sfa1p (formaldehyde dehydrogenase.)

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Metadata

Authors
Dickinson, J. R., Salgado, L. E. J., & Hewlins, M. J. E.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2003-03
Volume
278
Issue
10
Pages
8028-8034
ISSN
0021-9258 (ISSN-L)
OpenAlex
W2124144946
Cited by
375
References
20
FWCI
20.00
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: The Catabolism of Amino Acids to Long Chain and Complex Alcohols in Saccharomyces cerevisiae. https://app.cochat.ai/papers/10.1074/jbc.m211914200
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Dickinson, J. R., Salgado, L. E. J., & Hewlins, M. J. E. (2003). The Catabolism of Amino Acids to Long Chain and Complex Alcohols in Saccharomyces cerevisiae. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m211914200

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