The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Prostaglandin E2 Induced Functional Expression of Early Growth Response Factor-1 by EP4, but Not EP2, Prostanoid Receptors via the Phosphatidylinositol 3-Kinase and Extracellular Signal-regulated Kinases
Open accessAbstract
Prostaglandin E(2) (PGE(2)) mediates its physiological effects by interactions with a subfamily of G-protein-coupled receptors known as EP receptors. These receptors consist of four primary subtypes named EP(1), EP(2), EP(3), and EP(4). The EP(2) and EP(4) subtypes are known to couple to Galpha(s) and stimulate intracellular cyclic 3,5- adenosine monophosphate formation, whereas the EP(1) and EP(3) receptors are known to couple to Galpha(q) and Galpha(i), respectively. Recently we found that EP(2) and EP(4) receptors can activate T-cell factor signaling; however, EP(2) receptors did this primarily through a cAMP-dependent protein kinase-dependent pathway, whereas EP(4) receptors primarily utilized a phosphatidylinositol 3-kinase (PI3K)-dependent pathway (Fujino, H., West, K. A., and Regan, J. W. (2002) J. Biol. Chem. 277, 2614-2619). We now report that PGE(2) stimulation of EP(4) receptors, but not EP(2) receptors, leads to phosphorylation of the extracellular signal-regulated kinases (ERKs) through a PI3K-dependent mechanism. Furthermore, this activation of PI3K/ERK signaling by the EP(4) receptors induces the functional expression of early growth response factor-1 (EGR-1). Under the same conditions induction of EGR-1 protein expression was not observed following PGE(2) stimulation of EP(2) receptors. These findings point to important differences in the signaling potential of the EP(2) and EP(4) receptors, which could be significant with respect to the potential involvement of EP(4) receptors in inflammation and cancer.
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Cites
β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
Tetsu, O., & McCormick, F. (1999) · Nature · doi:10.1038/18884 · Cited by 3,601
Rodriguez-Viciana, P., Warne, P. H., Khwaja, A., Marte, B. M., Pappin, D., Das, P., Waterfield, M. D., Ridley, A., & Downward, J. (1997) · Cell · doi:10.1016/s0092-8674(00)80226-3 · Cited by 1,061
Prostaglandin E2 Increases Growth and Motility of Colorectal Carcinoma Cells
Sheng, H., Shao, J., Washington, M. K., & DuBois, R. N. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009689200 · Cited by 653
Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice
Sonoshita, M., Takaku, K., Sasaki, N., Sugimoto, Y., Ushikubi, F., Narumiya, S., Oshima, M., & Taketo, M. M. (2001) · Nature Medicine · doi:10.1038/nm0901-1048 · Cited by 587
Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice.
Chulada, P. C., Thompson, M. B., Mahler, J. F., Doyle, C. M., Gaul, B. W., Lee, C., Tiano, H. F., Morham, S. G., Smithies, O., & Langenbach, R. J. (2000) · PubMed · Cited by 496
Lipopolysaccharide Induction of the Tumor Necrosis Factor-α Promoter in Human Monocytic Cells
Yao, J., Mackman, N., Edgington, T. S., & Fan, S.-T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.28.17795 · Cited by 457
Regan, J. W., Bailey, T. J., Pepperl, D. J., Pierce, K. L., Bogardus, A. M., Donello, J. E., Fairbairn, C. E., Kedzie, K. M., Woodward, D. F., & Gil, D. W. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09674-9 · Cited by 390
Self-citationInvolvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.
Mutoh, M., Watanabe, K., Kitamura, T., Shoji, Y., Takahashi, M., Kawamori, T., Tani, K., Kobayashi, M., Maruyama, T., Kobayashi, K., et al. (2002) · PubMed · Cited by 362
The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis
McCoy, J. M., Wicks, J. R., & Audoly, L. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15528 · Cited by 352
Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis.
Watanabe, K., Kawamori, T., Nakatsugi, S., Ohta, T., Ohuchida, S., Yamamoto, H., Maruyama, T., Kondo, K., Ushikubi, F., Narumiya, S., et al. (1999) · PubMed · Cited by 351
Cited by
Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors
Kawahara, K., Hohjoh, H., Inazumi, T., Tsuchiya, S., & Sugimoto, Y. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.07.008 · Cited by 488
Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis
Behar, S. M., Martin, C. J., Booty, M. G., Nishimura, T., Zhao, X., Gan, H.-X., Divangahi, M., & Remold, H. G. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.3 · Cited by 447
Molecular mechanisms underlying prostaglandin E2-exacerbated inflammation and immune diseases
Tsuge, K., Inazumi, T., Shimamoto, A., & Sugimoto, Y. (2019) · International Immunology · doi:10.1093/intimm/dxz021 · Cited by 263
Metadata
- Authors
- Fujino, H., Xu, W., & Regan, J. W.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-04
- Volume
- 278
- Issue
- 14
- Pages
- 12151-12156
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2058034672
- Cited by
- 305
- References
- 26
- FWCI
- 11.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Fujino, H., Xu, W., & Regan, J. W. (2003). Prostaglandin E2 Induced Functional Expression of Early Growth Response Factor-1 by EP4, but Not EP2, Prostanoid Receptors via the Phosphatidylinositol 3-Kinase and Extracellular Signal-regulated Kinases. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m212665200
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