DNA Damage-induced MDMX Degradation Is Mediated by MDM2

Kawai, Hidehiko, Wiederschain, Dmitri, Kitao, Hiroyuki, Stuart, Jeremy, Tsai, Kelvin K.C., Yuan, Zhi-Min·2003·Journal of Biological Chemistry
DOI 10.1074/jbc.m308295200

Cited by (163)

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  10. Mouse modelling of the MDM2/MDMX−p53 signalling axis
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  12. Modification of MDMX by sumoylation
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  14. PIG3 Regulates p53 Stability by Suppressing Its MDM2-Mediated Ubiquitination
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  15. Real-Time Quantitative PCR Analysis of Gene Dosages Reveals Gene Amplification in Low-Grade Oligodendrogliomas
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  17. MDM2 oligomers: antagonizers of the guardian of the genome
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  18. Regulation of MDM4 (MDMX) function by p76MDM2: a new facet in the control of p53 activity
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  20. Heterozygous p53V172F mutation in cisplatin-resistant human tumor cells promotes MDM4 recruitment and decreases stability and transactivity of p53
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  21. Expanding the horizon of chemotherapeutic targets: From MDM2 to MDMX (MDM4)
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  22. Deconstructing nucleotide binding activity of the Mdm2 RING domain
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  27. Targeting the conformational transitions of MDM2 and MDMX: Insights into key residues affecting p53 recognition
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  28. Screening E3 Substrates Using a Live Phage Display Library
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  29. Mdm2 and MdmX Involvement in Human Cancer
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  30. Molecular Targeting of the Most Functionally Complex Gene in Precision Oncology: p53
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  31. Inactivation of the MDM2 RING domain enhances p53 transcriptional activity in mice
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  32. p53 Regulation Goes Live--Mdm2 and MdmX Co-Star: Lessons Learned from Mouse Modeling
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  33. Mdm2 Plays a Positive Role as an Effector of p53-Dependent Responses
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  34. p53-mediated metabolic response to low doses of ionizing radiation
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  35. Gatekeepers of the Guardian: p53 Regulation by Post-Translational Modification, MDM2 and MDMX
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  36. Functional Interrogation of the N-Terminal Lid of MDMX in p53 Binding via Native Chemical Ligation
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  41. RING Fingers and Relatives: Determinators of Protein Fate
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  42. Cooperation between MDM2 and MDMX in the Regulation of p53
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  43. Set the Tone:
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  45. Modulation of p53 activities by the prolyl-isomerase PIN1 and the bromodomain protein BRD7
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  47. Modification of MDMX by Ubiquitination and Sumoylation
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  49. p53 and DNA damage checkpoint responses in the human prostate
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  50. Increased Radioresistance and Accelerated B Cell LymphomasinMicewithMdmxMutationsthatPrevent
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  51. Modulation of the Mdm2 signaling axis sensitizes triple-negative breast cancer cells to carboplatin
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  52. Characterization of the Ubiquitin/Nedd8 E3 ligase activity of the Mdm2/MdmX complex
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  53. Exploring Chromatin-bound MDM2 Functions in Compromised Transcriptional Regulation of p53 Target Genes
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  54. In Vivo Discoveries in MDM2-Mediated p53 Regulation
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  55. New insight into the role of MDMX in MDM2-mediated p53 degradation and anti-cancer drug development
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  56. MDM4 (Murine Double Minute 4)
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  57. MDM4 (Murine Double Minute 4)
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  58. Data from RING Domain–Mediated Interaction Is a Requirement for MDM2's E3 Ligase Activity
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  59. Data from RING Domain–Mediated Interaction Is a Requirement for MDM2's E3 Ligase Activity
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  60. Data from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
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  61. Implication de la voie p53 dans les syndromes d'insuffisance médullaire
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  62. BindingDB Entry 50018099: Recent Progress and Clinical Development of Inhibitors that Block MDM4/p53 Protein-Protein Interactions.
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  63. Structure, Dynamics, and Evolution of the Intrinsically Disordered p53 Transactivation Domain
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