The DOI matches its Crossref record.
Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5-MMP, to the plasma membrane by binding to its carboxyl end motif EWV.
Abstract
Membrane type matrix metalloproteinases (MT-MMPs) play a critical role in promoting cell growth and migration within the extracellular matrix by trafficking to specialized areas. Here we show that the carboxyl EWV motif of MT5-MMP serves as a retrieval signal for internalized MT5-MMP by interacting with Mint-3, a protein with two type III PDZ domains. Deletion of the EWV signal impairs the recycling of MT5-MMP without affecting its internalization, leading to decreased activity on the cell surface. A yeast two-hybrid screening identified Mint-3 as the EWV-binding protein. Mint-3 stimulates MT5-MMP activity when expressed at low levels in an EWV-dependent fashion, but inhibits its activity at higher levels independent of the EWV motif. siRNA-mediated knockdown of endogenous Mint-3 decreased MT5-MMP activity. Furthermore, Mint-3 significantly increased the level of MT5-MMP on the cell surface without affecting its synthesis and internalization. Therefore, Mints may be the adaptor proteins that regulate the trafficking of MT-MMPs.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
MT5-MMP can be internalized in endosomes and thus promote endosomal APP sorting.
“MT5-MMP can be internalized in endosomes (Wang et al., 2004; Baranger et al., 2017a) and thus promote endosomal APP sorting (Baranger et al., 2017a).”
From Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP (2019) · cites this paper as Wang et al., 2004
MT5-MMP trafficking involves interactions between the last three residues at carboxyl terminus and Mint3, a protein that contains two type III PDZ domains.
“MT5-MMP trafficking involves interactions between the last three residues at carboxyl terminus and Mint3, a protein that contains two type III PDZ domains (Wang et al., 2004).”
From Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP (2019) · cites this paper as Wang et al., 2004
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 25
- Yamada, 2003, Nature, 424, 889, 10.1038/424889a · DOI
- Hotary, 2003, Cell, 114, 33, 10.1016/S0092-8674(03)00513-0 · DOI
- Sato, 1994, Nature, 370, 61, 10.1038/370061a0 · DOI
- Birkedal-Hansen, 1993, Crit. Rev. Oral Biol. Med., 4, 197, 10.1177/10454411930040020401 · DOI
- Lopez-Otin, 2002, Nat. Rev. Mol. Cell. Biol., 3, 509, 10.1038/nrm858 · DOI · Paper page
- Pei, 1999, Cell Res., 9, 291, 10.1038/sj.cr.7290028 · DOI
- Kang, 2000, FASEB J., 14, 2559, 10.1096/fj.00-0269com · DOI
- Jiang, 2003, J. Biol. Chem., 278, 38765, 10.1074/jbc.M306618200 · DOI
- Jiang, 2001, Proc. Natl. Acad. Sci. U. S. A., 98, 13693, 10.1073/pnas.241293698 · DOI
- Uekita, 2001, J. Cell Biol., 155, 1345, 10.1083/jcb.200108112 · DOI
- Remacle, 2003, J. Cell Sci., 116, 3905, 10.1242/jcs.00710 · DOI
- Wang, 2003, J. Biol. Chem., 279, 9331, 10.1074/jbc.M312369200 · DOI
- Rozanov, 2002, FEBS Lett., 527, 51, 10.1016/S0014-5793(02)03153-8 · DOI
- Llano, 1999, Cancer Res., 59, 2570
- Hayashita-Kinoh, 2001, Cell Growth Differ., 12, 573
- Pei, 1999, J. Biol. Chem., 274, 8925, 10.1074/jbc.274.13.8925 · DOI
- Kang, 2001, J. Biol. Chem., 276, 21960, 10.1074/jbc.M007997200 · DOI
- Yang, 2002, J. Biol. Chem., 277, 30219, 10.1074/jbc.M111933200 · DOI
- Okamoto, 1998, Eur. J. Cell Biol., 77, 161, 10.1016/S0171-9335(98)80103-9 · DOI
- Okamoto, 2001, Neuroscience, 104, 653, 10.1016/S0306-4522(01)00124-5 · DOI
- Okamoto, 1997, J. Biol. Chem., 272, 31459, 10.1074/jbc.272.50.31459 · DOI
- Ho, 2003, Proc. Natl. Acad. Sci. U. S. A., 100, 1409, 10.1073/pnas.252774899 · DOI
- Holmbeck, 1999, Cell, 99, 81, 10.1016/S0092-8674(00)80064-1 · DOI · Paper page
- Zhou, 2000, Proc. Natl. Acad. Sci. U. S. A., 97, 4052, 10.1073/pnas.060037197 · DOI · Paper page
- Nourry, 2003, Sci. STKE, 2003, RE7, 10.1126/stke.2003.179.re7 · DOI
Cited by
Sorted by citations
García-González, L., Pilat, D., Baranger, K., & Rivera, S. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00244 · Cited by 88
Metadata
- Authors
- Wang, P., Wang, X., & Pei, D.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 279
- Issue
- 19
- Pages
- 20461-20470
- ISSN
- 0021-9258
- Cited by
- 57
- References
- 0
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
