Global Suppression of IL-6-induced Acute Phase Response Gene Expression after Chronic in Vivo Treatment with the Peroxisome Proliferator-activated Receptor-α Activator Fenofibrate

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Fenofibrate (a PPAR-α Agonist) Administered During Ethanol Withdrawal Reverts Ethanol-Induced Astrogliosis and Restores the Levels of Glutamate Transporter in Ethanol-Administered Adolescent Rats

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PPAR-αAgonist Fenofibrate Decreased Serum Irisin Levels in Type 2 Diabetes Patients with Hypertriglyceridemia

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Tumour necrosis factor alpha down-regulates the expression of peroxisome proliferator activated receptor alpha (PPARα) in human hepatocarcinoma HepG2 cells by activation of NF-κB pathway

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CD47 Deficiency in Mice Exacerbates Chronic Fatty Diet-Induced Steatohepatitis Through Its Role in Regulating Hepatic Inflammation and Lipid Metabolism

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Pemafibrate Dramatically Ameliorated the Values of Liver Function Tests and Fibrosis Marker in Patients with Non-Alcoholic Fatty Liver Disease

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Evaluation of substances used in the GenX technology by Chemours, Dordrecht

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Peroxisome Proliferator Activated Receptor-αAgonist Slows the Progression of Hypertension, Attenuates Plasma Interleukin-6 Levels and Renal Inflammatory Markers in Angiotensin II Infused Mice

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Interleukin-6 inhibition of peroxisome proliferator-activated receptor alpha expression is mediated by JAK2- and PI3K-induced STAT1/3 in HepG2 hepatocyte cells

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Decrease in inflammatory cardiovascular risk markers in hyperlipidemic diabetic patients treated with fenofibrate.

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Proteome Dynamics Reveals Pro-Inflammatory Remodeling of Plasma Proteome in a Mouse Model of NAFLD

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Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is maintained

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Activation of PPARα Ameliorates Cardiac Fibrosis in Dsg2-Deficient Arrhythmogenic Cardiomyopathy

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Regulation of nutrient metabolism and inflammation.

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Fenofibrate Inhibited the Differentiation of T Helper 17 CellsIn Vitro

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β (CCL2) and α (CXCL10) chemokine modulations by cytokines and peroxisome proliferator-activated receptor-α agonists in Graves' ophthalmopathy

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Plantagiolides I and J, Two New Withanolide Glucosides from Tacca plantaginea with Nuclear Factor-kappaB Inhibitory and Peroxisome Proliferator-Activated Receptor Transactivational Activities

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Fenofibrate, a peroxisome proliferator-activated receptor α-agonist, blocks lipopolysaccharide-induced inflammatory pathways in mouse liver

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Effect of pemafibrate (K-877), a novel selective peroxisome proliferator-activated receptor α modular (SPPARMα), in atherosclerosis model using low density lipoprotein receptor knock-out swine with balloon injury

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Coronary Flow Velocity Reserve is Improved by PPAR‐α Agonist Fenofibrate in Patients with Hypertriglyceridemia

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Endocannabinoid-Like Lipid Neuromodulators in the Regulation of Dopamine Signaling: Relevance for Drug Addiction

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Discovery of Novel Peroxisome Proliferator-Activated Receptor α (PPARα) Agonists by Virtual Screening and Biological Evaluation

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Limosilactobacillus reuteri FN041 prevents atopic dermatitis in pup mice by remodeling the ileal microbiota and regulating gene expression in Peyer’s patches after vertical transmission

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A unique tetrameric structure of deer plasma haptoglobin – an evolutionary advantage in the Hp 2‐2 phenotype with homogeneous structure

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Peroxisome Proliferator-Activated Receptor α Physically Interacts with CCAAT/Enhancer Binding Protein (C/EBPβ) to Inhibit C/EBPβ-Responsive α1-Acid Glycoprotein Gene Expression

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PPAR-Alpha Agonist Fenofibrate Combined with Octreotide Acetate in the Treatment of Acute Hyperlipidemia Pancreatitis

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PPAR and Liver Injury in HIV‐Infected Patients

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Cyclosorus terminans Extract Ameliorates Insulin Resistance and Non-Alcoholic Fatty Liver Disease (NAFLD) in High-Fat Diet (HFD)-Induced Obese Rats

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Roles of N-Acylethanolamines in Brain Functions and Neuropsychiatric Diseases

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How PPAR-alpha mediated inflammation may affect the pathophysiology of chronic kidney disease

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Peroxisome Proliferator-Activated Receptor Agonists: Do They Increase Cardiovascular Risk?

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Transcriptional regulation of retinol binding protein 4 by Interleukin-6 via peroxisome proliferator-activated receptor α and CCAAT/Enhancer binding proteins

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Diarylheptanoid glycosides from Tacca plantaginea and their effects on NF-κB activation and PPAR transcriptional activity

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Analysis of gene expression changes in relation to hepatotoxicity induced by perfluorinated chemicals in a human hepatoma cell line

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Therapeutical effects of PPAR agonists assessed by biomarker modulation

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In vitro microarray analysis identifies genes in acute-phase response pathways that are down-regulated in the liver of chicken embryos exposed in ovo to PFUdA

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The interaction between HCV and nuclear receptor-mediated pathways

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Peroxisome Proliferator-Activated Receptor α Agonists Differentially Regulate Inhibitor of DNA Binding Expression in Rodents and Human Cells

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Gene modulation associated with inhibition of liver regeneration in hepatitis B virus X transgenic mice

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Effects of Dietary Polyunsaturated Fatty Acids on Lactation Performance, Tissue Gene Expression, and Reproduction in Dairy Cows

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Fenofibrate-induced massive regression of mutiple inflammatory hepatocellular adenoma

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Selective PPARα Modulator (SPPARMα) in the Era of the MASLD Pandemic: Current Insights and Future Prospects

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COL6A6 Peptide Vaccine Alleviates Atherosclerosis through Inducing Immune Response and Regulating Lipid Metabolism in Apoe−/− Mice

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Plasma oxylipin profile of postpartum dairy cows categorized into different systemic inflammatory grades in the first week after parturition

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Adrenoceptor-stimulated inflammatory response in stress-induced serum amyloid A synthesis

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Biomarkers of Metabolism and Inflammation in Individuals with Obesity and Normal Weight: A Comparative Analysis Exploring Sex Differences

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Sijunzi, Lizhong, and Fuzilizhong Decoction Alleviate Nonalcoholic Fatty Liver Disease through Activation of PPAR Pathway

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D-allulose enhances lipid oxidation in HepG2 cells via peroxisome proliferator-activated receptor α (PPARα)

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Peroxisome proliferator-activated receptorα (PPARα) agonists down-regulate α2-macroglobulin expression by a PPARα-dependent mechanism☆

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Récepteurs nucléaires PPAR et hépatologie : implications physiopathologiques et thérapeutiques

Dharancy, S., Louvet, A., Hollebecque, A., Desreumaux, P., Mathurin, P., & Dubuquoy, L. (2008) · Gastroentérologie Clinique et Biologique · doi:10.1016/j.gcb.2008.01.029 · Cited by 4

PPARs: Important Regulators in Metabolism and Inflammation

Sanderson, L. M., & Kersten, S. (2010) · Springer eBooks · doi:10.1007/978-90-481-3303-1_10 · Cited by 4

Potential Neuroprotective Strategies for Traumatic Brain Injury

Farooqui, A. A. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6652-0_7 · Cited by 4

β‐elemene ameliorates metabolic dysfunction‐associated steatohepatitis by targeting PPARα in experimental diet‐induced models

Xiong, Y., Luo, W., Ye, J., Cui, Y., Zheng, X., Jin, L., Lou, S., Zhang, Q., Wang, A., Fang, Y., et al. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70161 · Cited by 3

Measuring Biomarkers to Assess the Therapeutic Effects of Ppar Agonists?

Chinetti, G., & Staels, B. (2007) · Pharmacogenomics · doi:10.2217/14622416.8.11.1567 · Cited by 3

Safety and Efficacy of Peroxisome Proliferator-Activated Receptor-α Agonist for Treating Cardiovascular Disease

Kang, Y.-R., Kwak, C. H., & Hwang, J. (2007) · Korean Circulation Journal · doi:10.4070/kcj.2007.37.12.599 · Cited by 2

Effects of dietary pomegranate peel polyphenols on antioxidant capacity, immunity, lipid metabolism, and hepatointestinal health for golden pompano (Trachinotus ovatus)

Liu, G., Yu, Z., Li, S., Zhao, S., Zhou, M., & Tan, X. (2025) · Aquaculture International · doi:10.1007/s10499-024-01807-7 · Cited by 2

Insulin Resistance, Chronic Inflammation and the Link with Immunosenescence

Mazzatti, D. J., Karnik, K., Oita, R. C., & Powell, J. R. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_60 · Cited by 2

New therapeutic perspectives in non-alcoholic steatohepatitis

Ampuero, J., Sanchez-Torrijos, Y. M., Aguilera, V., Bellido, F., & Romero‐Gómez, M. (2018) · Gastroenterología y Hepatología (English Edition) · doi:10.1016/j.gastre.2017.07.016 · Cited by 2

Study of the effect of bezafibrate with ginkgo biloba extracts in an animal model of hepatotoxicity induced by doxorubicin

Abdalla, Z. A., Abtar, A. N., Kareem, A. A., Ahmed, Z. A., & Aziz, T. A. (2023) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2023.101582 · Cited by 2

Pathology of Arterial Thrombosis

Lamichhane, M., Salehi, N., Ahmadjee, A., & Abela, G. S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812615-8.00002-8 · Cited by 2

Pathophysiologic Basis for Alternative Therapies for Cholestasis

Fuchs, C. D., Halilbasic, E., & Trauner, M. (2020) · Wiley eBooks · doi:10.1002/9781119436812.ch30 · Cited by 2

Oleoylethanolamide facilitates PPARa and TFEB signaling and attenuates Ab pathology in a mouse model of Alzheimer’s diseasePreprint

Comerota, M. M., Gedam, M., Xiong, W., Jin, F., Deng, L., Wang, M. C., Wang, J., & Zheng, H. (2023) · Research Square · doi:10.21203/rs.3.rs-2484513/v1 · Cited by 4

Loss of SVIP Results in Metabolic Reprograming and Increased Retention of Very-Low-Density Lipoproteins in Hepatocytes

Sekhar, V., Andl, T., & Siddiqi, S. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157465 · Cited by 1

Nonoperative Management of Hepatic Adenomas: A Review

Garbarine, I. C., & Cloyd, J. M. (2026) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-026-01406-0 · Cited by 1

Integration of mechanistic and repeat dose toxicity data in the derivation of an oral reference dose for HFPO-DA

Thompson, C. M., Heintz, M. M., Rogers, S., Vincent, M. J., & Haws, L. C. (2026) · Toxicological Sciences · doi:10.1093/toxsci/kfag045 · Cited by 1

Mechanism of Transcriptional Regulation of C-Reactive Protein Gene Expression.

Voleti, B. (2007) · Digital Commons - East Tennessee State University (East Tennessee State University) · Cited by 1

Les mécanismes de l'inflammation périphérique

Raymondjean, M. (2007) · Revue Francophone des Laboratoires · doi:10.1016/s1773-035x(07)80058-x · Cited by 1

Biochemical Alterations and Endothelial Dysfunction in Hypercholesterolemic Rats: Effects of Bezafibrate

Abo-Zaid, O. A., Hasanin, M., & Hanafi, A. (2013) · Journal of Investigational Biochemistry · doi:10.5455/jib.20130305012038 · Cited by 1

Protective Effects of Fenofibrate Against the Inflammatory Cytokines in Lipopolysaccharide-Induced Mice Brain Tissues

Park, H. W., Su Jin Yoo, M. D., & Park, J. H. (2012) · Journal of the Korean Geriatrics Society · doi:10.4235/jkgs.2012.16.4.206 · Cited by 1

Factors that Influence Fenofibrate Effects on Cancer Cells

Vlahopoulos, S. (2014) · Journal of Hematology and Oncology Research · doi:10.14302/issn.2372-6601.jhor-13-362

Endocannabinoids and Related Lipids in Chronic Pain : Analytical and Clinical Aspects

Stensson, N. (2018) · Linköping University medical dissertations · doi:10.3384/diss.diva-147653 · Cited by 1

The role of PPARs in inflammation and obesity

Stienstra, R. (2007) · doi:10.18174/121898 · Cited by 1

Doxycycline inhibition of proteases and inflammation in abdominal aortic aneurysms

Khawaja, H. A. (2011) · Leiden Repository (Leiden University)

Gene Expression Profiling in Hepatic Tissue of two Pig Breeds

Jang, G.-W., Lee, K., Park, J., Kim, H., Kim, T.-H., Choi, B., Kim, M. J., & Lim, D. (2012) · Journal of Animal Science and Technology · doi:10.5187/jast.2012.54.6.383

Role of interleukin-6 in states of metabolic health and disease

Holmes, A. G. (2010) · RMIT Research Repository (RMIT University Library) · doi:10.25439/rmt.27354477

Interleukin-6 Induces the Down Regulation of Human Peroxisome Proliferator Activated Receptor Alpha via the MAPK-induced STAT Pathway in Human Hepatocytes

Chew, G.-S., Myers, S., OOI, K. L., Shu-Chien, A., & Muhammad, T. (2013) · eCite Digital Repository (University of Tasmania)

Overview of insulin resistance and the metabolic syndrome

Sattar, N. A., & Mukhopadhyay, B. (2003) · CRC Press eBooks · doi:10.3109/9780203481165-13

Transcriptional Regulation of Mitochondrial Biogenesis and Quality Control

Suliman, H. B., & Piantadosi, C. A. (2015) · Oxidative stress and disease · doi:10.1201/b19420-6

Systemic and Distal Repercussions of Liver-Specific Peroxisome Proliferator-Activated Receptor-α Control of the Acute-Phase Response

Mansouri, R. M., Baugé, E., Staels, B., & Gervois, P. P. (2008) · Endocrinology · doi:10.1210/en.2007-1339 · Cited by 63

Fenofibrate, a peroxisome proliferator-activated receptor α-agonist, blocks lipopolysaccharide-induced inflammatory pathways in mouse liver

Won, T. W. (2013) · Korean Journal of Hepato-Biliary-Pancreatic Surgery · doi:10.14701/kjhbps.2013.17.3.89 · Cited by 18

Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

Delerive, P., De Bosscher, K., Besnard, S., Vanden Berghe, W., Peters, J. M., Gonzalez, F. J., Fruchart, J.-C., Tedgui, A., Haegeman, G., & Staels, B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32048 · Cited by 1,089

Negative Regulation of Human Fibrinogen Gene Expression by Peroxisome Proliferator-activated Receptor α Agonists via Inhibition of CCAAT Box/Enhancer-binding Protein β

Gervois, P. P., Vu‐Dac, N., Kleemann, R., Kockx, M., Dubois, G., Laine, B., Kosykh, V., Fruchart, J., Kooistra, T., & Staels, B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102839200 · Cited by 159

Interleukin-6 inhibition of peroxisome proliferator-activated receptor alpha expression is mediated by JAK2- and PI3K-induced STAT1/3 in HepG2 hepatocyte cells

Chew, G.-S., Myers, S., Shu‐Chien, A. C., & Muhammad, T. S. T. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1896-z · Cited by 22