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A Novel Marker of Tissue Junctions, Collagen XXII
Open accessAbstract
Here we describe a novel specific component of tissue junctions, collagen XXII. It was first identified by screening an EST data base and subsequently expressed as a recombinant protein and characterized as an authentic tissue component. The COL22A1 gene on human chromosome 8q24.2 encodes a collagen that structurally belongs to the FACIT protein family (fibril-associated collagens with interrupted triple helices). Collagen XXII exhibits a striking restricted localization at tissue junctions such as the myotendinous junction in skeletal and heart muscle, the articular cartilage-synovial fluid junction, or the border between the anagen hair follicle and the dermis in the skin. It is deposited in the basement membrane zone of the myotendinous junction and the hair follicle and associated with the extrafibrillar matrix in cartilage. In situ hybridization of myotendinous junctions revealed that muscle cells produce collagen XXII, and functional tests demonstrated that collagen XXII acts as a cell adhesion ligand for skin epithelial cells and fibroblasts. This novel gene product, collagen XXII, is the first specific extracellular matrix protein present only at tissue junctions.
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Cited by
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Ricard-Blum, S., & Ruggiero, F. (2005) · Pathologie Biologie · doi:10.1016/j.patbio.2004.12.024 · Cited by 428
Prehistoric genomes reveal the genetic foundation and cost of horse domestication
Schubert, M., Jónsson, H., Chang, D., Der Sarkissian, C., Ermini, L., Ginolhac, A., Albrechtsen, A., Dupanloup, I., Foucal, A., Petersen, B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1416991111 · Cited by 324
Metadata
- Authors
- Koch, M., Schulze, J., Hansen, U., Ashwodt, T., Keene, D. R., Brunken, W. J., Burgeson, R. E., Bruckner, P., & Bruckner-Tuderman, L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 279
- Issue
- 21
- Pages
- 22514-22521
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1990829493
- Cited by
- 229
- References
- 0
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Koch, M., Schulze, J., Hansen, U., Ashwodt, T., Keene, D. R., Brunken, W. J., Burgeson, R. E., Bruckner, P., & Bruckner-Tuderman, L. (2004). A Novel Marker of Tissue Junctions, Collagen XXII. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m400536200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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