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A Recombinant Human Hemoglobin with Anti-sickling Properties Greater than Fetal Hemoglobin
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“Notably, T87Q was subsequently incorporated by Genetix (the precursor of bluebird bio) into the BB305 LVV vector that ultimately was approved by the FDA for treatment of β-thalassemia and SCD (Zynteglo and Levgenia, see below).[75][76][77]”
From Ex vivo modification of hematopoietic stem and progenitor cells for gene therapy (2025) · cites this paper as [75]
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Citations
Cites
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A Specific Chemical Difference Between the Globins of Normal Human and Sickle-Cell Anæmia Hæmoglobin
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Cited by
CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells
Dever, D. P., Bak, R. O., Reinisch, A., Camarena, J., Washington, G., Nicolas, C. E., Pavel-Dinu, M., Saxena, N., Wilkens, A. B., Mantri, S., et al. (2016) · Nature · doi:10.1038/nature20134 · Cited by 864
Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease
Hoban, M. D., Orkin, S. H., & Bauer, D. E. (2016) · Blood · doi:10.1182/blood-2015-09-618587 · Cited by 194
Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype.
Brendel, C., Guda, S., Renella, R., Bauer, D. E., Canver, M. C., Kim, Y.-J., Heeney, M. M., Klatt, D., Fogel, J., Milsom, M. D., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87885 · Cited by 167
Ex vivo modification of hematopoietic stem and progenitor cells for gene therapy
Williams, D. A., Kohn, D. B., & Thrasher, A. J. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.03.058 · Cited by 11
Metadata
- Authors
- Levasseur, D. N., Ryan, T. M., Reilly, M. P., McCune, S. L., Asakura, T., & Townes, T. M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2004-06
- Volume
- 279
- Issue
- 26
- Pages
- 27518-27524
- ISSN
- 0021-9258
- Cited by
- 67
- References
- 5
- Language
- en
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- CoChat. (2026). Citation check: A Recombinant Human Hemoglobin with Anti-sickling Properties Greater than Fetal Hemoglobin. https://app.cochat.ai/papers/10.1074/jbc.m402578200
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- Levasseur, D. N., Ryan, T. M., Reilly, M. P., McCune, S. L., Asakura, T., & Townes, T. M. (2004). A Recombinant Human Hemoglobin with Anti-sickling Properties Greater than Fetal Hemoglobin. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m402578200
