The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Significance of Respirasomes for the Assembly/Stability of Human Respiratory Chain Complex I
Open accessAbstract
We showed that the human respiratory chain is organized in supramolecular assemblies of respiratory chain complexes, the respirasomes. The mitochondrial complexes I (NADH dehydrogenase) and III (cytochrome c reductase) form a stable core respirasome to which complex IV (cytochrome c oxidase) can also bind. An analysis of the state of respirasomes in patients with an isolated deficiency of single complexes provided evidence that the formation of respirasomes is essential for the assembly/stability of complex I, the major entry point of respiratory chain substrates. Genetic alterations leading to a loss of complex III prevented respirasome formation and led to the secondary loss of complex I. Therefore, primary complex III assembly deficiencies presented as combined complex III/I defects. This dependence of complex I assembly/stability on respirasome formation has important implications for the diagnosis of mitochondrial respiratory chain disorders.
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Cites
ENZYMATIC PROPERTIES OF THE INNER AND OUTER MEMBRANES OF RAT LIVER MITOCHONDRIA
Schnaitman, C., & Greenawalt, J. W. (1968) · The Journal of Cell Biology · doi:10.1083/jcb.38.1.158 · Cited by 1,386
Supercomplexes in the respiratory chains of yeast and mammalian mitochondria
Schägger, H., & Pfeiffer, K. (2000) · The EMBO Journal · doi:10.1093/emboj/19.8.1777 · Cited by 1,356
Self-citationThe genetics and pathology of oxidative phosphorylation
Smeitink, J., van den Heuvel, L., & DiMauro, S. (2001) · Nature Reviews Genetics · doi:10.1038/35072063 · Cited by 724
Respiratory Complex III Is Required to Maintain Complex I in Mammalian Mitochondria
Acı́n-Pérez, R., Bayona-Bafaluy, M. P., Fernández-Silva, P., Moreno-Loshuertos, R., Pérez-Martos, A., Bruno, C., Moraes, C. T., & Enrı́quez, J. A. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00124-8 · Cited by 475
Exercise Intolerance Due to Mutations in the Cytochrome b Gene of Mitochondrial DNA
Andreu, A. L., Hanna, M. G., Reichmann, H., Bruno, C., Penn, A. S., Tanji, K., Pallotti, F., Iwata, S., Bonilla, E., Lach, B., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909303411404 · Cited by 431
Schägger, H., & Pfeiffer, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106474200 · Cited by 403
Self-citationHackenbrock, C. R., Chazotte, B., & Gupte, S. S. (1986) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf00743010 · Cited by 384
Respiratory chain supercomplexes of mitochondria and bacteria
Schägger, H. (2002) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(02)00271-2 · Cited by 363
Self-citationElectron and proton transfers through quinones and cytochrome bc complexes
Rich, P. R. (1984) · Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics · doi:10.1016/0304-4173(84)90007-7 · Cited by 347
de Lonlay, P., Valnot, I., Barrientos, A., Gorbatyuk, M., Tzagoloff, A., Taanman, J.-W., Benayoun, E., Chrétien, D., Kadhom, N., Lombès, A., et al. (2001) · Nature Genetics · doi:10.1038/ng706 · Cited by 320
Cited by
Hauptmann, S., Scherping, I., Dröse, S., Brandt, U., Schulz, K. L., Jendrach, M., Leuner, K., Eckert, A., & Müller, W. E. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.12.005 · Cited by 469
Self-citationPich, S., Bach, D., Briones, P., Liesa, M., Camps, M., Testar, X., Palacín, M., & Zorzano, A. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi149 · Cited by 455
The Assembly Pathway of Mitochondrial Respiratory Chain Complex I
Guerrero-Castillo, S., Baertling, F., Kownatzki, D., Wessels, H. J., Arnold, S., Brandt, U., & Nijtmans, L. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.002 · Cited by 423
Self-citationMammalian Mitochondrial Complex I: Biogenesis, Regulation, and Reactive Oxygen Species Generation
Koopman, W. J. H., Nijtmans, L. G. J., Dieteren, C. E. J., Roestenberg, P., Valsecchi, F., Smeitink, J. A. M., & Willems, P. H. G. M. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2743 · Cited by 411
Cytochrome c oxidase dysfunction in oxidative stress
Srinivasan, S., & Avadhani, N. G. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.021 · Cited by 373
Metadata
- Authors
- Schägger, H., de Coo, R., Bauer, M. F., Hofmann, S., Godinot, C., & Brandt, U.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2004-08
- Volume
- 279
- Issue
- 35
- Pages
- 36349-36353
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2073947021
- Cited by
- 317
- References
- 28
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Schägger, H., de Coo, R., Bauer, M. F., Hofmann, S., Godinot, C., & Brandt, U. (2004). Significance of Respirasomes for the Assembly/Stability of Human Respiratory Chain Complex I. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m404033200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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