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Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines.

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Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival.

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Structure of the Complex between the Antibiotic Cerulenin and Its Target, β-Ketoacyl-Acyl Carrier Protein Synthase

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Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53.

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Fatty Acid Synthase (Fas) Predictive Strength in Poorly Differentiated Early Breast Carcinomas

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Immunohistochemical Expression of Human Erythrocyte Glucose Transporter and Fatty Acid Synthase in Infiltrating Breast Carcinomas and Adjacent Typical/Atypical Hyperplastic or Normal Breast Tissue

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Mapping the Functional Topology of the Animal Fatty Acid Synthase by Mutant Complementation in Vitro

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Apoptosis of androgen-independent prostate cell line induced by inhibition of fatty acid synthesis.

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Mapping of Functional Interactions between Domains of the Animal Fatty Acid Synthase by Mutant Complementation in vitro

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Key role of mitochondria in cerulenin-mediated apoptosis

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The architecture of the animal fatty acid synthetase. II. Separation of the core and thioesterase functions and determination of the N-C orientation of the subunit.

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Insights into a plasma membrane signature

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The N-Terminal Domains of Cyclin-Dependent Kinase Inhibitory Proteins Block the Phosphorylation of cdk2/Cyclin E by the CDK-Activating Kinase

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Cellular pharmacology of cerulenin analogs that inhibit protein palmitoylation11Abbreviations: FT-IR, Fourier transform infrared; THF, tetrahydrofuran; FBS, fetal bovine serum; FPTase, farnesyl protein transferase; PPTase, protein palmitoyltransferase; FTI, farnesyl transferase inhibitor; DTT, dithiothreitol.

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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

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Targeting cellular metabolism to improve cancer therapeutics

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Fatty Acid Synthase As a Potential Therapeutic Target in Cancer

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Disruption of Hepatic Adipogenesis Is Associated With Impaired Liver Regeneration in Mice

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Activity-Based Proteome Profiling of Potential Cellular Targets of Orlistat − An FDA-Approved Drug with Anti-Tumor Activities

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Metabolic signaling pathways asociated with fatty acid synthase activity

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Fatty acid synthase inhibition induces apoptosis independent of lipid metabolism

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Inhibition of fatty acid synthase activates the unfolded protein response in tumor cells

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Inhibition of Fatty Acid Synthase in Prostate Cancer by Orlistat, a Novel Therapeutic

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Inhibition of Fatty-acid Synthase Induces Caspase-8-mediated Tumor Cell Apoptosis by Up-regulating DDIT4

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