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Identification of T Cell Death-associated Gene 8 (TDAG8) as a Novel Acid Sensing G-protein-coupled Receptor
Open accessAbstract
T cell death-associated gene 8 (TDAG8) is a G-protein-coupled receptor mainly expressed in lymphoid organs and cancer tissues. TDAG8 shares high amino acid sequence homologies with recently reported proton-sensing G-protein-coupled receptors, G2A, OGR1, and GPR4. Here we have identified TDAG8 as a novel proton-sensing receptor. Upon acid stimulation, stably expressed TDAG8 was internalized from the plasma membrane. As a signaling pathway downstream of TDAG8, accumulation of cyclic AMP was observed in response to solutions with a pH value lower than 7.2. Furthermore, RhoA activation and actin rearrangement were elicited by acid-stimulated TDAG8. These results suggest that TDAG8 may play biological roles in immune response and cellular transformation under conditions accompanying tissue acidosis.
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Cites
Rho signals to cell growth and apoptosis
Aznar, S., & Lacal, J. C. (2001) · Cancer Letters · doi:10.1016/s0304-3835(01)00412-8 · Cited by 310
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Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immunomodulation
Huber, V., Camisaschi, C., Berzi, A., Ferro, S., Lugini, L., Triulzi, T., Tuccitto, A., Tagliabue, E., Castelli, C., & Rivoltini, L. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.03.001 · Cited by 595
Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy
Pilon-Thomas, S., Kodumudi, K. N., El-Kenawi, A. E., Russell, S., Weber, A. M., Luddy, K., Damaghi, M., Wojtkowiak, J. W., Mulé, J. J., Ibrahim-Hashim, A., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-1743 · Cited by 593
pH sensing and regulation in cancer
Damaghi, M., Wojtkowiak, J. W., & Gillies, R. J. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00370 · Cited by 536
Lysophospholipid receptors: Signalling, pharmacology and regulation by lysophospholipid metabolism
Meyer zu Heringdorf, D., & Jakobs, K. H. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.09.026 · Cited by 388
Acidic tumor microenvironment and pH-sensing G protein-coupled receptors
Justus, C. R., Dong, L., & Yang, L. V. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00354 · Cited by 374
Metadata
- Authors
- Ishii, S., Kihara, Y., & Shimizu, T.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-03
- Volume
- 280
- Issue
- 10
- Pages
- 9083-9087
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2055769271
- Cited by
- 193
- References
- 1
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Identification of T Cell Death-associated Gene 8 (TDAG8) as a Novel Acid Sensing G-protein-coupled Receptor. https://app.cochat.ai/papers/10.1074/jbc.m407832200
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- Ishii, S., Kihara, Y., & Shimizu, T. (2005). Identification of T Cell Death-associated Gene 8 (TDAG8) as a Novel Acid Sensing G-protein-coupled Receptor. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m407832200
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