The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Polypeptide GalNAc-transferase T3 and Familial Tumoral Calcinosis
Open accessAbstract
Mutations in the gene encoding the glycosyltransferase polypeptide GalNAc-T3, which is involved in initiation of O-glycosylation, were recently identified as a cause of the rare autosomal recessive metabolic disorder familial tumoral calcinosis (OMIM 211900). Familial tumoral calcinosis is associated with hyperphosphatemia and massive ectopic calcifications. Here, we demonstrate that the secretion of the phosphaturic factor fibroblast growth factor 23 (FGF23) requires O-glycosylation, and that GalNAc-T3 selectively directs O-glycosylation in a subtilisin-like proprotein convertase recognition sequence motif, which blocks processing of FGF23. The study suggests a novel posttranslational regulatory model of FGF23 involving competing O-glycosylation and protease processing to produce intact FGF23.
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Hagen, K. G. T., & Tran, D. T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201807200 · Cited by 89
Cited by
The FGF family: biology, pathophysiology and therapy
Beenken, A., & Mohammadi, M. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2792 · Cited by 1,945
Precision mapping of the human O‐GalNAc glycoproteome through SimpleCell technology
Steentoft, C., Vakhrushev, S. Y., Joshi, H. J., Kong, Y., Vester‐Christensen, M. B., Schjoldager, K. T. G., Lavrsen, K., Dabelsteen, S., Pedersen, N. B., Marcos‐Silva, L., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.79 · Cited by 1,408
Self-citationGlobal view of human protein glycosylation pathways and functions
Schjoldager, K. T., Narimatsu, Y., Joshi, H. J., & Clausen, H. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00294-x · Cited by 1,309
Self-citationBennett, E. P., Mandel, U., Clausen, H., Gerken, T. A., Fritz, T. A., & Tabak, L. A. (2012) · Glycobiology · doi:10.1093/glycob/cwr182 · Cited by 876
Self-citationRegulation of Phosphate Homeostasis by PTH, Vitamin D, and FGF23
Bergwitz, C., & Jüppner, H. (2010) · Annual Review of Medicine · doi:10.1146/annurev.med.051308.111339 · Cited by 741
Metadata
- Authors
- Kato, K., Jeanneau, C., Tarp, M. A., Benet-Pagès, A., Lorenz-Depiereux, B., Bennett, E. P., Mandel, U., Strom, T. M., & Clausen, H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2006-07
- Volume
- 281
- Issue
- 27
- Pages
- 18370-18377
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1970052428
- Cited by
- 423
- References
- 1
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kato, K., Jeanneau, C., Tarp, M. A., Benet-Pagès, A., Lorenz-Depiereux, B., Bennett, E. P., Mandel, U., Strom, T. M., & Clausen, H. (2006). Polypeptide GalNAc-transferase T3 and Familial Tumoral Calcinosis. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m602469200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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