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Isolation and Characterization of Low Sulfated Heparan Sulfate Sequences with Affinity for Lipoprotein Lipase

Spillmann, Dorothe, Lookene, Aivar, Olivecrona, Gunilla·2006·Journal of Biological Chemistry
DOI 10.1074/jbc.m604702200
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  • In general, only 8-12 monosaccharide residues are needed to bind to many proteins, including LPL and apoE.

    “In general, only 8–12 monosaccharide residues are needed to bind to many proteins, including LPL and apoE (52–55), but the pattern of sulfate groups and uronic acids that mediate TRL binding is unknown.”

    From Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice (2009) · cites this paper as [53]

    The Figure 1 results report LPL-binding fragments as small as 8–10 monosaccharide residues, supporting the LPL example. The Discussion cautions that shorter fragments bind less strongly than full-length chains. Our copy does not establish the 8–12-residue range for many proteins or address apoE. (LLM, conf=0.86)

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Metadata

Authors
Spillmann, D., Lookene, A., & Olivecrona, G.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2006-08
Volume
281
Issue
33
Pages
23405-23413
ISSN
0021-9258
DOI
10.1074/jbc.m604702200
Cited by
24
References
0
Language
en
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