Crystal Structure of the P38α-MAPKAP Kinase 2 Heterodimer

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SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

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A conserved docking motif in MAP kinases common to substrates, activators and regulators

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The p38 MAP kinase pathway signals for cytokine‐induced mRNA stabilization via MAP kinase‐activated protein kinase 2 and an AU‐rich region‐targeted mechanism

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Refinement of severely incomplete structures with maximum likelihood inBUSTER–TNT

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An approach to multi-copy search in molecular replacement

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FGF and stress regulate CREB and ATF‐1 via a pathway involving p38 MAP kinase and MAPKAP kinase‐2.

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Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

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Novel Homologues of CSBP/p38 MAP Kinase: Activation, Substrate Specificity and Sensitivity to Inhibition by Pyridinyl Imidazoles

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Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases

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Mechanisms and functions of p38 MAPK signalling

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Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER

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Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2

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Molecular basis of MAP kinase regulation

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DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization

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p38 Pathway Kinases as Anti-inflammatory Drug Targets

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Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove

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Druggability Assessment of Allosteric Proteins by Dynamics Simulations in the Presence of Probe Molecules

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MAPK-Activated Protein Kinases: Servant or Partner?

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Current status and future prospects of p38α/MAPK14 kinase and its inhibitors

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Molecular basis of MAPK-activated protein kinase 2:p38 assembly

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Selective inhibition of the p38α MAPK–MK2 axis inhibits inflammatory cues including inflammasome priming signals

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Potential of p38-MAPK inhibitors in the treatment of ischaemic heart disease

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An updated patent review of p38 MAP kinase inhibitors (2014-2019)

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Targeting Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2, MK2): Medicinal Chemistry Efforts To Lead Small Molecule Inhibitors to Clinical Trials

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MK2: a novel molecular target for anti-inflammatory therapy

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MK2 and MK3 - a pair of isoenzymes?

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VEGF autoregulates its proliferative and migratory ERK1/2 and p38 cascades by enhancing the expression of DUSP1 and DUSP5 phosphatases in endothelial cells

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Revisiting protein kinase–substrate interactions: Toward therapeutic development

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A Distinct Interaction Mode Revealed by the Crystal Structure of the Kinase p38α with the MAPK Binding Domain of the Phosphatase MKP5

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MK2 Is Required for Neutrophil-Derived ROS Production and Inflammatory Bowel Disease

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Allosteric enhancement of MAP kinase p38α's activity and substrate selectivity by docking interactions

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Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation

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p38α MAPK Is a MTOC-associated protein regulating spindle assembly, spindle length and accurate chromosome segregation during mouse oocyte meiotic maturation

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Understanding the molecular basis of MK2–p38α signaling complex assembly: insights into protein–protein interaction by molecular dynamics and free energy studies

Yang, Y., Liu, H., & Yao, X. (2012) · Molecular BioSystems · doi:10.1039/c2mb25042j · Cited by 48

Biological functions and role of mitogen-activated protein kinase activated protein kinase 2 (MK2) in inflammatory diseases

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Role of MAPK Kinase 6 in Arthritis: Distinct Mechanism of Action in Inflammation and Cytokine Expression

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Mitogen‐activated protein kinase‐activated protein kinase‐2 (MK2) and its role in cell survival, inflammatory signaling, and migration in promoting cancer

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MK2-Dependent p38b Signalling Protects Drosophila Hindgut Enterocytes against JNK-Induced Apoptosis under Chronic Stress

Seisenbacher, G., Hafen, E., & Stocker, H. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002168 · Cited by 41

Specificity of signaling from MAPKs to MAPKAPKs: Kinases' Tango Nuevo

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Pivotal Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Inflammatory Pulmonary Diseases

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Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity

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A Role for MK2 in Enhancing Neutrophil-Derived ROS Production and Aggravating Liver Ischemia/Reperfusion Injury

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Structure-based design, synthesis and biological evaluation of N-pyrazole, N′-thiazole urea inhibitors of MAP kinase p38α

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Structural assembly of the signaling competent ERK2–RSK1 heterodimeric protein kinase complex

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Posttranscriptional regulation of gene expression—adding another layer of complexity to the DNA damage response

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Hydrogen-Exchange Mass Spectrometry Reveals Activation-Induced Changes in the Conformational Mobility of p38α MAP Kinase

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Novel tryptanthrin derivatives with benzenesulfonamide substituents: Design, synthesis, and anti-inflammatory evaluation

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The three-dimensional structure of MAP kinase p38β: different features of the ATP-binding site in p38β compared with p38α

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Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs

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MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer

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Determinants That Control the Distinct Subcellular Localization of p38α-PRAK and p38β-PRAK Complexes

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Low-Molecular-Weight Mk2 Inhibitors: A Tough Nut to Crack!

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The heat shock protein Hsp27 controls mitochondrial function by modulating ceramide generation

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Preventing p38 MAPK-mediated MafA degradation ameliorates β-cell dysfunction under oxidative stress.

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Anti-inflammatory effects of extracellular vesicles from Morchella on LPS-stimulated RAW264.7 cells via the ROS-mediated p38 MAPK signaling pathway

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Mitogen-activated protein kinase signaling and its association with oxidative stress and apoptosis in lead-exposed hepatocytes

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Protein–peptide complex crystallization: a case study on the ERK2 mitogen-activated protein kinase

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Targeting Diverse Signaling Interaction Sites Allows the Rapid Generation of Bivalent Kinase Inhibitors

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Co-Conserved MAPK Features Couple D-Domain Docking Groove to Distal Allosteric Sites via the C-Terminal Flanking Tail

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A Model of a MAPK•Substrate Complex in an Active Conformation: A Computational and Experimental Approach

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p38α Mitogen-Activated Protein Kinase Is a Druggable Target in Pancreatic Adenocarcinoma

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The interaction of p38 with its upstream kinase MKK6

Kumar, G. S., Page, R., & Peti, W. (2021) · Protein Science · doi:10.1002/pro.4039 · Cited by 25

Kinetic Mechanism and Inhibitor Characterization for c-jun-N-Terminal Kinase 3α1

Ember, B., Kamenecka, T., & LoGrasso, P. (2008) · Biochemistry · doi:10.1021/bi701852z · Cited by 22

DNA damage-inducible transcript 3 positively regulates RIPK1-mediated necroptosis

Ni, R., Cao, T., Ji, X., Peng, A., Zhang, Z., Fan, G., Stathopulos, P. B., Chakrabarti, S., Su, Z., & Peng, T. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01385-4 · Cited by 20

p38α MAP Kinase Dimers with Swapped Activation Segments and a Novel Catalytic Loop Conformation

Rothweiler, U., Åberg, E., Johnson, K. A., Hansen, T. E., Jørgensen, J. B., & Engh, R. A. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.06.013 · Cited by 20

Mitogen‐activated protein kinase‐activated protein kinase 2 (MK2) in skeletal muscle atrophy and hypertrophy

Norrby, M., & Tågerud, S. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22023 · Cited by 19

Docking Interactions of Hematopoietic Tyrosine Phosphatase with MAP Kinases ERK2 and p38α

Piserchio, A., Francis, D. M., Koveal, D., Dalby, K. N., Page, R., Peti, W., & Ghose, R. (2012) · Biochemistry · doi:10.1021/bi3012725 · Cited by 19

Selective Mitogen Activated Protein Kinase Activity Sensors through the Application of Directionally Programmable D Domain Motifs

Peterson, L. B., Yaffe, M. B., & Imperiali, B. (2014) · Biochemistry · doi:10.1021/bi500862c · Cited by 19

Identification of a Novel Inhibitory Allosteric Site in p38α

Gómez‐Gutierrez, P., Campos, P. M., Vega, M., & Pérez, J. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167379 · Cited by 19

MAP Kinase Mediated Activation of RSK1 and MK2 Substrate Kinases

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Proteome-wide screening for mitogen-activated protein kinase docking motifs and interactors

Shi, G., Song, C. D., Robles, J. T., Salichos, L., Lou, H. J., Lam, T. T., Gerstein, M., & Turk, B. E. (2023) · Science Signaling · doi:10.1126/scisignal.abm5518 · Cited by 20

High‐resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligand

Cheng, R., Felicetti, B., Palan, S., Toogood‐Johnson, I., Scheich, C., Barker, J. J., Whittaker, M. A., & Hesterkamp, T. (2009) · Protein Science · doi:10.1002/pro.294 · Cited by 18

Structural Basis for the Regulation of the Mitogen-activated Protein (MAP) Kinase p38α by the Dual Specificity Phosphatase 16 MAP Kinase Binding Domain in Solution

Kumar, G. S., Zettl, H., Page, R., & Peti, W. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.499178 · Cited by 12

Identification of Potential Small Molecule Binding Pockets in p38α MAP Kinase

Gómez‐Gutierrez, P., Rubio, J., & Pérez, J. J. (2017) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.7b00439 · Cited by 15

A temperature-dependent conformational shift in p38α MAPK substrate–binding region associated with changes in substrate phosphorylation profile

Deredge, D. J., Wintrode, P. L., Tulapurkar, M. E., Nagarsekar, A., Zhang, Y., Weber, D. J., Shapiro, P. S., & Hasday, J. D. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.007525 · Cited by 14

Discovery of a Potent Dihydrooxadiazole Series of Non-ATP-Competitive MK2 (MAPKAPK2) Inhibitors

Qin, J., Dhondi, P., Huang, X., Aslanian, R. G., Fossetta, J. D., Tian, F., Lundell, D. J., & Palani, A. (2011) · ACS Medicinal Chemistry Letters · doi:10.1021/ml200238g · Cited by 14

p38 alpha MAP kinase

Rousseau, S. (2011) · AfCS-Nature Molecule Pages · doi:10.1038/mp.a001717.01 · Cited by 13

Cross-species transcriptomic signatures predict response to MK2 inhibition in mouse models of chronic inflammation

Suárez-López, L., Shui, B., Brubaker, D. K., Hill, M., Bergendorf, A. M., Changelian, P. S., Laguna, A., Starchenko, A., Lauffenburger, D. A., & Haigis, K. M. (2021) · iScience · doi:10.1016/j.isci.2021.103406 · Cited by 13

NMR Spectroscopy to Study MAP Kinase Binding to MAP Kinase Phosphatases

Peti, W., & Page, R. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3746-2_11 · Cited by 13

Degradation of MK2 with natural compound andrographolide: A new modality for anti-inflammatory therapy

Tran, Q. T. N., Gan, P. X. L., Liao, W., Mok, Y., Chai, C. L. L., & Wong, W. S. F. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106861 · Cited by 12

Rational mutagenesis to support structure-based drug design: MAPKAP kinase 2 as a case study

Argiriadi, M. A., Sousa, S., Banach, D. L., Marcotte, D. J., Xiang, T., Tomlinson, M. J., Demers, M. D., Harris, C., Kwak, S., Hardman, J., et al. (2009) · BMC Structural Biology · doi:10.1186/1472-6807-9-16 · Cited by 11

The Crystal Structure of the Active Form of the C-Terminal Kinase Domain of Mitogen- and Stress-Activated Protein Kinase 1

Malakhova, M. L., D’Angelo, I., Kim, H. G., Kurinov, I. V., Bode, A. M., & Dong, Z. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.03.064 · Cited by 11

The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor

Kostenko, S., Khan, M. T. H., Sylte, I., & Moens, U. L. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0452-1 · Cited by 11

Umifenovir effectively inhibits IL-10 dependent persistent Coxsackie B4 virus infection

Zhang, S., Zhi, C., Li, H., Huang, D., Fan, Q., Cui, J., & Liang, C. (2017) · Antiviral Research · doi:10.1016/j.antiviral.2017.02.018 · Cited by 11

Monitoring Native p38α:MK2/3 Complexes via Trans Delivery of an ATP Acyl Phosphate Probe

Okerberg, E. S., Brown, H. E., Minimo, L., Alemayehu, S., Rosenblum, J. S., Patricelli, M. P., Nomanbhoy, T. K., & Kozarich, J. W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja4129907 · Cited by 8

Discovery and Characterization of MAPK-activated Protein Kinase-2 Prevention of Activation Inhibitors

Cumming, J. G., Debreczeni, J. E., Edfeldt, F., Evertsson, E., Harrison, M., Holdgate, G. A., James, M. J., Lamont, S. G., Oldham, K., Sullivan, J. E., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm501038s · Cited by 8

Advances in targeting p38 MAPK for cancer therapy: insights from molecular pharmacology and medicinal chemistry

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p38α MAPK inhibits stretch-induced JNK activation in cardiac myocytes through MKP-1

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