The DOI matches its Crossref record; 63 of the 66 references it cites were found in a registry or an index.
Internalized Antibodies to the Aβ Domain of APP Reduce Neuronal Aβ and Protect against Synaptic Alterations
Open accessAbstract
Immunotherapy against beta-amyloid peptide (Abeta) is a leading therapeutic direction for Alzheimer disease (AD). Experimental studies in transgenic mouse models of AD have demonstrated that Abeta immunization reduces Abeta plaque pathology and improves cognitive function. However, the biological mechanisms by which Abeta antibodies reduce amyloid accumulation in the brain remain unclear. We provide evidence that treatment of AD mutant neuroblastoma cells or primary neurons with Abeta antibodies decreases levels of intracellular Abeta. Antibody-mediated reduction in cellular Abeta appears to require that the antibody binds to the extracellular Abeta domain of the amyloid precursor protein (APP) and be internalized. In addition, treatment with Abeta antibodies protects against synaptic alterations that occur in APP mutant neurons.
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“Limited examples include application of anti-Ab mAbs into neuronal culture derived from APP SW mice, whereby mAbs after binding to extracellular APP domain became internalized, resulting in reduced intraneuronal Ab accumulation.58”
From Blocking the Interaction between Apolipoprotein E and Aβ Reduces Intraneuronal Accumulation of Aβ and Inhibits Synaptic Degeneration (2013) · cites this paper as [58]
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“Remarkably, it was demonstrated that Aβ antibodies can reduce the intraneuronal pool of Aβ in vivo [138] and in vitro [189], which for the latter was shown to required Aβ antibody internalization.”
From Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease (2010) · cites this paper as [189]
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Citations
Cites
Alzheimer's Disease Is a Synaptic Failure
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Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
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Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
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Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
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Research works printed but not linked: 1
- Tabira, 2002, Front. Biosci., 7, a44
Cited by
Sorted by citations
Asuni, A. A., Boutajangout, A., Quartermain, D., & Sigurdsson, E. M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2361-07.2007 · Cited by 506
Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease
Gouras, G. K., Tampellini, D., Takahashi, R. H., & Capetillo-Zarate, E. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0679-9 · Cited by 372
Self-citationCan Alzheimer disease be prevented by amyloid-β immunotherapy?
Lemere, C. A., & Masliah, E. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.219 · Cited by 351
β-amyloid Peptides and Amyloid Plaques in Alzheimer's Disease
Gouras, G. K., Olsson, T. T., & Hansson, O. (2014) · Neurotherapeutics · doi:10.1007/s13311-014-0313-y · Cited by 346
Self-citationBoutajangout, A., Ingadottir, J., Davies, P., & Sigurdsson, E. M. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07337.x · Cited by 306
Metadata
- Authors
- Tampellini, D., Magrané, J., Takahashi, R. H., Li, F., Lin, M. T., Almeida, C. G., & Gouras, G. K.
- Affiliations
- Cornell University (US)
- Corresponding author
- Gouras, Gunnar K.
- ORCID
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 282
- Issue
- 26
- Pages
- 18895-18906
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2037318277
- Cited by
- 118
- References
- 66
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 8 · 2019: 3 · 2018: 1 · 2017: 7 · 2016: 4 · 2015: 4 · 2014: 9 · 2013: 8 · 2012: 4
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Alzheimer's Association
- American Health Assistance Foundation
- Dana Foundation
- National Institutes of Health
- National Institute on Aging (K02AG028174, AG028174)
- National Institute of Neurological Disorders and Stroke (R01NS045677, NS 045677)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- amyloid-beta, amyloid precursor protein, antibody internalization, immunotherapy, Alzheimer's disease, synaptic changes, neuroblastoma cells, antibody specificity
- MeSH terms
- Alzheimer Disease, Animals, Antibodies, Monoclonal, Antibody Specificity, Antigen-Antibody Complex, Endocytosis, Immunization, Mice, Transgenic, Neuroblastoma, Neurons, Synapses, Temperature, Amyloid beta-Protein Precursor, Protein Structure, Tertiary, Cell Line, Tumor, Mice, Amyloid Precursor Protein Secretases
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