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The Neutrophil-specific Antigen CD177 Is a Counter-receptor for Platelet Endothelial Cell Adhesion Molecule-1 (CD31)
Open accessAbstract
Human neutrophil-specific CD177 (NB1 and PRV-1) has been reported to be up-regulated in a number of inflammatory settings, including bacterial infection and granulocyte-colony-stimulating factor application. Little is known about its function. By flow cytometry and immunoprecipitation studies, we identified platelet endothelial cell adhesion molecule-1 (PECAM-1) as a binding partner of CD177. Real-time protein-protein analysis using surface plasmon resonance confirmed a cation-dependent, specific interaction between CD177 and the heterophilic domains of PECAM-1. Monoclonal antibodies against CD177 and against PECAM-1 domain 6 inhibited adhesion of U937 cells stably expressing CD177 to immobilized PECAM-1. Transendothelial migration of human neutrophils was also inhibited by these antibodies. Our findings provide direct evidence that neutrophil-specific CD177 is a heterophilic binding partner of PECAM-1. This interaction may constitute a new pathway that participates in neutrophil transmigration.
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Citations
Cited by
Neutrophil Diversity in Health and Disease
Silvestre-Roig, C., Fridlender, Z. G., Glogauer, M., & Scapini, P. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.04.012 · Cited by 522
Neutrophils at the crossroads of innate and adaptive immunity
Rosales, C. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mir0220-574rr · Cited by 372
PECAM-1: regulator of endothelial junctional integrity
Privratsky, J. R., & Newman, P. J. (2014) · Cell and Tissue Research · doi:10.1007/s00441-013-1779-3 · Cited by 366
Self-citationLeukocyte – endothelial interactions in inflammation
Langer, H. F., & Chavakis, T. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00811.x · Cited by 344
Self-citationCatchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes
Hasenberg, A., Hasenberg, M., Männ, L., Neumann, F., Borkenstein, L., Stecher, M., Kraus, A., Engel, D. R., Klingberg, A., Seddigh, P., et al. (2015) · Nature Methods · doi:10.1038/nmeth.3322 · Cited by 277
Metadata
- Authors
- Sachs, U. J. H., Andrei-Selmer, C. L., Maniar, A., Weiss, T., Paddock, C., Orlova, V. V., Choi, E. Y., Newman, P. J., Preissner, K. T., Chavakis, T., & Santoso, S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 282
- Issue
- 32
- Pages
- 23603-23612
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2033358607
- Cited by
- 241
- References
- 0
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Sachs, U. J. H., Andrei-Selmer, C. L., Maniar, A., Weiss, T., Paddock, C., Orlova, V. V., Choi, E. Y., Newman, P. J., Preissner, K. T., Chavakis, T., & Santoso, S. (2007). The Neutrophil-specific Antigen CD177 Is a Counter-receptor for Platelet Endothelial Cell Adhesion Molecule-1 (CD31). Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m701120200
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
