Cited by 187Plant Stress Responses and TolerancePlant Molecular Biology ResearchPlant-Microbe Interactions and Immunity

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TINY, a Dehydration-responsive Element (DRE)-binding Protein-like Transcription Factor Connecting the DRE- and Ethylene-responsive Element-mediated Signaling Pathways in Arabidopsis

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Sun, Shan, Yu, Jun-Ping, Chen, Feng, Zhao, Tong-Jin, Fang, Xiao-Hong, Li, Yi-Qin, Sui, Sen-Fang·2008·Journal of Biological Chemistry

DOI 10.1074/jbc.m706800200

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Abstract

Dehydration-responsive element-binding proteins (DREBs) and ethylene-responsive element (ERE) binding factors are two major subfamilies of the AP2/ethylene-responsive element-binding protein family and play crucial roles in the regulation of abiotic- and biotic-stress responses, respectively. In the present work, we have reported a previously identified DREB-like factor, TINY, that was involved in both abiotic- and biotic-stress signaling pathways. TINY was capable of binding to both DRE and ERE with similar affinity and could activate the expression of reporter genes driven by either of these two elements in tobacco cells. The 15th amino acid in the APETALA2 (AP2)/ethylene-responsive element-binding factor domain was demonstrated to be essential for its specific binding to ERE, whereas the 14th and 19th amino acids were responsible for the binding to DRE. The expression of TINY was greatly activated by drought, cold, ethylene, and slightly by methyl jasmonate. Additionally, overexpression of TINY in Arabidopsis resulted in elevated expressions of both the DRE- and the ERE-containing genes. Moreover, the expression of DRE-regulated genes, such as COR6.6 and ERD10, was up-regulated upon ethylene treatment, and the expression of ERE-regulated genes, such as HLS1, was also increased by cold stress, when the expression of TINY was being induced. These results strongly suggested that TINY might play a role in the cross-talk between abiotic- and biotic-stress-responsive gene expressions by connecting the DRE- and ERE-mediated signaling pathways. The results herein might promote the understanding of the mechanisms of specific DNA recognition and gene expression regulation by DREBs.

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Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Signals from Chloroplasts Converge to Regulate Nuclear Gene Expression
Koussevitzky, S., Nott, A., Mockler, T. C., Hong, F., Sachetto‐Martins, G., Surpin, M. A., Lim, J. C.-S., Mittler, R., & Chory, J. (2007) · Science · doi:10.1126/science.1140516 · Cited by 5,765
Two transcription factors, DREB1 and DREB2, with an EREBP/AP2 DNA binding domain separate two cellular signal transduction pathways in drought-and low-temperature-responsive gene expression, respectively, in Arabidopsis
Liu, Q., Kasuga, M., Sakuma, Y., Abe, H., Miura, S., Yamaguchi-Shinozaki, K., & Shinozaki, K. (1998) · The Plant Cell · doi:10.1105/tpc.10.8.1391 · Cited by 3,044
Ethylene in plant biology
Abeles, F. B. (1973) · Cited by 2,876
Arabidopsis Transcription Factors: Genome-Wide Comparative Analysis Among Eukaryotes
Riechmann, J. L., Heard, J. E., Martin, G., Reuber, T. L., Jiang, C., Keddie, J. S., Adam, L., Pineda, O., Ratcliffe, O. J., Samaha, R. R., et al. (2000) · Science · doi:10.1126/science.290.5499.2105 · Cited by 2,844
Improving plant drought, salt, and freezing tolerance by gene transfer of a single stress-inducible transcription factor
Kasuga, M., Liu, Q., Miura, S., Yamaguchi‐Shinozaki, K., & Shinozaki, K. (1999) · Nature Biotechnology · doi:10.1038/7036 · Cited by 2,105
A Novel cis-Acting Element in an Arabidopsis Gene Is Involved in Responsiveness to Drought, Low-Temperature, or High-Salt Stress
Yamaguchi‐Shinozaki, K., & Shinozaki, K. (1994) · The Plant Cell · doi:10.1105/tpc.6.2.251 · Cited by 2,061
DNA-binding specificity of the ERF/AP2 domain of Arabidopsis DREBs, transcription factors involved in dehydration-and cold-inducible gene expression
Sakuma, Y., Liu, Q., Dubouzet, J. G., Abe, H., Shinozaki, K., & Yamaguchi-Shinozaki, K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6299 · Cited by 1,993
Arabidopsis thaliana CBF1 encodes an AP2 domain-containing transcriptional activator that binds to the C-repeat/DRE, a cis-acting DNA regulatory element that stimulates transcription in response to low temperature and water deficit
Stockinger, E. J., Gilmour, S. J., & Thomashow, M. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.3.1035 · Cited by 1,807
Arabidopsis CBF1 Overexpression Induces COR Genes and Enhances Freezing Tolerance
Jaglo‐Ottosen, K. R., Gilmour, S. J., Zarka, D. G., Schabenberger, O., & Thomashow, M. F. (1998) · Science · doi:10.1126/science.280.5360.104 · Cited by 1,692
OsDREB genes in rice, Oryza sativa L., encode transcription activators that function in drought‐, high‐salt‐ and cold‐responsive gene expression
Dubouzet, J. G., Sakuma, Y., Ito, Y., Kasuga, M., Dubouzet, E. G., Miura, S., Seki, M., Shinozaki, K., & Yamaguchi‐Shinozaki, K. (2003) · The Plant Journal · doi:10.1046/j.1365-313x.2003.01661.x · Cited by 1,660
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Shinozaki, K., & Yamaguchi‐Shinozaki, K. (2000) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(00)80068-0 · Cited by 1,616
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Lorenzo, Ó., Piqueras, R., Sánchez‐Serrano, J. J., & Solano, R. (2002) · The Plant Cell · doi:10.1105/tpc.007468 · Cited by 1,411
Ethylene-Inducible DNA Binding Proteins That Interact with an Ethylene-Responsive Element
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Fujimoto, S. Y., Ohta, M., Usui, A., Shinshi, H., & Ohme‐Takagi, M. (2000) · The Plant Cell · doi:10.1105/tpc.12.3.393 · Cited by 1,074
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Guo, H., & Ecker, J. R. (2003) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2003.11.011 · Cited by 988
Review
Riechmann, J. L., & Meyerowitz, E. M. (1998) · Biological Chemistry · doi:10.1515/bchm.1998.379.6.633 · Cited by 831
SA, JA, ethylene, and disease resistance in plants
Dong, X. (1998) · Current Opinion in Plant Biology · doi:10.1016/1369-5266(88)80053-0 · Cited by 728
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Mitsuhara, I., Ugaki, M., Hirochika, H., Ohshima, M., Murakami, T., Gotoh, Y., Katayose, Y., Nakamura, S., Honkura, R., Nishimiya, S., et al. (1996) · Plant and Cell Physiology · doi:10.1093/oxfordjournals.pcp.a028913 · Cited by 569
Overexpression of the Tobacco Tsi1 Gene Encoding an EREBP/AP2-Type Transcription Factor Enhances Resistance against Pathogen Attack and Osmotic Stress in Tobacco
Park, J. M., Park, C.-J., Lee, S.-B., Ham, B., Shin, R., & Paek, K.-H. (2001) · The Plant Cell · doi:10.1105/tpc.13.5.1035 · Cited by 507
The Role of Ethylene in Host-Pathogen Interactions
Broekaert, W. F., Delauré, S. L., Bolle, M. F. C. D., & Cammue, B. P. A. (2006) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.44.070505.143440 · Cited by 505
A novel mode of DNA recognition by a β‐sheet revealed by the solution structure of the GCC‐box binding domain in complex with DNA
Allen, M. D., Yamasaki, K., Ohme‐Takagi, M., Tateno, M., & Suzuki, M. (1998) · The EMBO Journal · doi:10.1093/emboj/17.18.5484 · Cited by 490
Strong, constitutive expression of the Arabidopsis ACT2/ACT8 actin subclass in vegetative tissues
An, Y., McDowell, J. M., Huang, S., McKinney, E. C., Chambliss, S., & Meagher, R. B. (1996) · The Plant Journal · doi:10.1046/j.1365-313x.1996.10010107.x · Cited by 459
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Lehman, A. W., Black, R., & Ecker, J. R. (1996) · Cell · doi:10.1016/s0092-8674(00)81095-8 · Cited by 457
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Medina, J., Bargues, M., Terol, J., Pérez‐Alonso, M., & Salinas, J. (1999) · PLANT PHYSIOLOGY · doi:10.1104/pp.119.2.463 · Cited by 443
A Role for the GCC-Box in Jasmonate-Mediated Activation of the PDF1.2 Gene of Arabidopsis
Brown, R. L., Kazan, K., McGrath, K., Maclean, D. J., & Manners, J. M. (2003) · PLANT PHYSIOLOGY · doi:10.1104/pp.102.017814 · Cited by 422
Organization and expression of two Arabidopsis DREB2 genes encoding DRE-binding proteins involved in dehydration- and high-salinity-responsive gene expression
Nakashima, K., Shinwari, Z. K., Sakuma, Y., Seki, M., Miura, S., Shinozaki, K., & Yamaguchi‐Shinozaki, K. (2000) · Plant Molecular Biology · doi:10.1023/a:1006321900483 · Cited by 405
Unique Mode of GCC Box Recognition by the DNA-binding Domain of Ethylene-responsive Element-binding Factor (ERF Domain) in Plant
Hao, D., Ohme‐Takagi, M., & Sarai, A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.41.26857 · Cited by 405
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Qin, F., Sakuma, Y., Li, J., Liu, Q., Li, Y.-Q., Shinozaki, K., & Yamaguchi‐Shinozaki, K. (2004) · Plant and Cell Physiology · doi:10.1093/pcp/pch118 · Cited by 398
Self-citation
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Wilson, K., Long, D., Swinburne, J. E., & Coupland, G. (1996) · The Plant Cell · doi:10.1105/tpc.8.4.659 · Cited by 249
Identification of Arabidopsis Ethylene-Responsive Element Binding Factors with Distinct Induction Kinetics after Pathogen Infection,
Oñate‐Sánchez, L., & Singh, K. B. (2002) · PLANT PHYSIOLOGY · doi:10.1104/pp.010862 · Cited by 228
A comparison of eukaryotic viral 5′-leader sequences as enhancers of mRNA expressionin vivo
Gallie, D., Sleat, D. E., Watts, J. W., Turner, P., & Wilson, T. M. A. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.21.8693 · Cited by 218
The Pepper Transcription FactorCaPF1Confers Pathogen and Freezing Tolerance in Arabidopsis
Yi, S. Y., Kim, J.-H., Joung, Y.-H., Lee, S., Kim, W.-T., Yu, S. H., & Choi, D. (2004) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.042903 · Cited by 205
The promoter of the plant defensin gene PDF1.2 from Arabidopsis is systemically activated by fungal pathogens and responds to methyl jasmonate but not to salicylic acid
Manners, J. M., Penninckx, I. A. M. A., Vermaere, K., Kazan, K., Brown, R. L., Morgan, A., Maclean, D. J., Curtis, M. D., Cammue, B. P. A., & Broekaert, W. F. (1998) · Plant Molecular Biology · doi:10.1023/a:1006070413843 · Cited by 200
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Wang, H., Huang, Z., Chen, Q., Zhang, Z., Zhang, H., Wu, Y., Huang, D., & Huang, R. (2004) · Plant Molecular Biology · doi:10.1007/s11103-004-0113-6 · Cited by 178
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Zhao, T., Sun, S., Liu, Y., Liu, J.-M., Liu, Q., Yan, Y., & Hai‐Meng, Z. H. O. U. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510535200 · Cited by 171
Self-citation
Data analysis of interaction forces measured with the atomic force microscope
Baumgärtner, W., Hinterdorfer, P., & Schindler, H. (2000) · Ultramicroscopy · doi:10.1016/s0304-3991(99)00154-0 · Cited by 156
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Lee, J. H., Hong, J.-P., Oh, S., Lee, S., Choi, D., & Kim, W. S. (2004) · Plant Molecular Biology · doi:10.1007/s11103-004-0417-6 · Cited by 138
Tomato TERF1 modulates ethylene response and enhances osmotic stress tolerance by activating expression of downstream genes
Huang, Z., Zhang, Z., Zhang, X., Zhang, H., Huang, D., & Huang, R. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.064 · Cited by 129
Determinants in the Sequence Specific Binding of Two Plant Transcription Factors, CBF1 and NtERF2, to the DRE and GCC Motifs
Hao, D., Yamasaki, K., Sarai, A., & Ohme‐Takagi, M. (2002) · Biochemistry · doi:10.1021/bi015979v · Cited by 117
The conserved Ala37 in the ERF/AP2 domain is essential for binding with the DRE element and the GCC box
Liu, Y., Zhao, T., Liu, J.-M., Liu, W.-Q., Liu, Q., Yan, Y., & Hai‐Meng, Z. H. O. U. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.01.048 · Cited by 95
Self-citation
Effect of Two Conserved Amino Acid Residues on DREB1A Function
Cao, Z.-F., Li, J., Chen, F., Li, Y.-Q., Hai‐Meng, Z. H. O. U., & Liu, Q. (2001) · Biochemistry (Moscow) · doi:10.1023/a:1010251129429 · Cited by 58
Self-citation
Molecular Cloning, Phylogenetic Analysis, Expressional Profiling and In Vitro Studies of TINY2 from Arabidopsis thaliana
Wei, G., Pan, Y. M., Lei, J., & Zhu, Y. (2005) · BMB Reports · doi:10.5483/bmbrep.2005.38.4.440 · Cited by 56
Two novel AP2/ERF domain proteins interact with cis‐element VWRE for wound‐induced expression of the Tobacco tpoxN1 gene
Sasaki, K., Mitsuhara, I., Seo, S., Ito, H., Matsui, H., & Ohashi, Y. (2007) · The Plant Journal · doi:10.1111/j.1365-313x.2007.03111.x · Cited by 55
Rescue of defective auxin-mediated gene expression and root meristem function by inhibition of ethylene signalling in sterol biosynthesis mutants of Arabidopsis
Souter, M. A., Pullen, M., Topping, J. F., Zhang, X., & Lindsey, K. (2004) · Planta · doi:10.1007/s00425-004-1280-z · Cited by 28
Single molecule study of binding force between transcription factorTINY and its DNA responsive element
Yu, J., Sun, S., Jiang, Y., Ma, X., Chen, F., Zhang, G., & Fang, X. (2006) · Polymer · doi:10.1016/j.polymer.2005.12.087 · Cited by 17
Self-citation

Research works printed but not linked: 8

Ohme-Takagi, 1995, Plant Cell, 7, 173
Fujimoto, 2000, Plant Cell, 12, 393
Koussevitzky, 2007, Science, 316, 715, 10.1126/science. 1140516 · DOI · Paper page
Wilson, 1996, Plant Cell, 8, 659
Zhifang, 2001, Tsinghua Sci. Technol., 6, 432
Yamaguchi-Shinozaki, 1994, Plant Cell, 6, 251
Wei, 2005, J. Biochem. Mol. Biol., 38, 440
Park, 2001, Plant Cell, 13, 1035

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Authors: Sun, S., Yu, J.-P., Chen, F., Zhao, T.-J., Fang, X.-H., Li, Y.-Q., & Sui, S.-F.
Affiliations: Tsinghua University (CN)
Chinese Academy of Sciences (CN)
Corresponding author: Sui, Sen-Fang
ORCID: Sun, Shan
Chen, Feng
Zhao, Tong-Jin
Sui, Sen-Fang
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2008-03
Volume: 283
Issue: 10
Pages: 6261-6271
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m706800200
OpenAlex: W2002771652
Cited by: 187
References: 46
Citations by year: 2026: 8 · 2025: 10 · 2024: 24 · 2023: 3 · 2022: 16 · 2021: 5 · 2020: 13 · 2019: 10 · 2018: 4 · 2017: 11 · 2016: 9 · 2015: 13 · 2014: 6 · 2013: 15 · 2012: 9
FWCI: 8.88
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 4613 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
Keywords: dehydration-responsive element, AP2/ERF family, abiotic stress signaling, stress-responsive gene expression, drought stress, cold stress, ethylene signaling, methyl jasmonate, DNA binding specificity, Arabidopsis thaliana
MeSH terms: Acetates, Cold Temperature, Cyclopentanes, Dehydration, Disasters, Ethylenes, Nuclear Proteins, Plant Growth Regulators, Signal Transduction, Arabidopsis, Protein Structure, Tertiary, Homeodomain Proteins, Gene Expression Regulation, Plant, Response Elements, Arabidopsis Proteins, Oxylipins

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TINY, a Dehydration-responsive Element (DRE)-binding Protein-like Transcription Factor Connecting the DRE- and Ethylene-responsive Element-mediated Signaling Pathways in Arabidopsis

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