The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Histone Arg Modifications and p53 Regulate the Expression of OKL38, a Mediator of Apoptosis
Open accessAbstract
Protein Arg methyltransferases function as coactivators of the tumor suppressor p53 to regulate gene expression. Peptidylarginine deiminase 4 (PAD4/PADI4) counteracts the functions of protein Arg methyltransferases in gene regulation by deimination and demethylimination. Here we show that the expression of a tumor suppressor gene, OKL38, is activated by the inhibition of PAD4 or the activation of p53 following DNA damage. Chromatin immunoprecipitation assays showed a dynamic change of p53 and PAD4 occupancy and histone Arg modifications at the OKL38 promoter during DNA damage, suggesting a direct role of PAD4 and p53 in the expression of OKL38. Furthermore, we found that OKL38 induces apoptosis through localization to mitochondria and induction of cytochrome c release. Together, our studies identify OKL38 as a novel p53 target gene that is regulated by PAD4 and plays a role in apoptosis.
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Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607
Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis
Oda, E., Ohki, R., Murasawa, H., Nemoto, J., Shibue, T., Yamashita, T., Tokino, T., Taniguchi, T., & Tanaka, †. N. (2000) · Science · doi:10.1126/science.288.5468.1053 · Cited by 2,112
The p53 pathway: positive and negative feedback loops
Harris, S. L., & Levine, A. J. (2005) · Oncogene · doi:10.1038/sj.onc.1208615 · Cited by 1,967
DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis
Crighton, D., Wilkinson, S., O'Prey, J., Syed, N., Smith, P., Harrison, P. R., Gasco, M., Garrone, O., Crook, T., & Ryan, K. M. (2006) · Cell · doi:10.1016/j.cell.2006.05.034 · Cited by 1,380
Cited by
Wang, Y., Li, M., Stadler, S., Correll, S., Li, P., Wang, D., Hayama, R., Leonelli, L., Han, H., Grigoryev, S. A., et al. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200806072 · Cited by 1,521
Self-citationOxidative stress in health and disease: The therapeutic potential of Nrf2 activation
Hybertson, B. M., Gao, B., Bose, S. K., & McCord, J. M. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.006 · Cited by 1,015
Metabolic reprogramming and epigenetic modifications on the path to cancer
Sun, L., Zhang, H., & Gao, P. (2022) · Protein & Cell · doi:10.1007/s13238-021-00846-7 · Cited by 770
Brennan, M. S., Matos, M. F., Richter, K. E., Li, B., & Scannevin, R. H. (2017) · Scientific Reports · doi:10.1038/srep42054 · Cited by 87
Metadata
- Authors
- Yao, H., Li, P., Venters, B. J., Zheng, S., Thompson, P. R., Pugh, B. F., & Wang, Y.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 283
- Issue
- 29
- Pages
- 20060-20068
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2057896776
- Cited by
- 160
- References
- 4
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Yao, H., Li, P., Venters, B. J., Zheng, S., Thompson, P. R., Pugh, B. F., & Wang, Y. (2008). Histone Arg Modifications and p53 Regulate the Expression of OKL38, a Mediator of Apoptosis. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m802940200
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