The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF
Open accessAbstract
Posttranslational histone modifications serve to store epigenetic information and control both nucleosome assembly and recruitment of non-histone proteins. Histone methylation occurs on arginine and lysine residues and is involved in the regulation of gene transcription. A dynamic control of these modifications is exerted by histone methyltransferases and the recently discovered histone demethylases. Here we show that the hypoxia-inducible factor HIF-1alpha binds to specific recognition sites in the genes encoding the jumonji family histone demethylases JMJD1A and JMJD2B and induces their expression. Accordingly, hypoxic cells express elevated levels of JMJD1A and JMJD2B mRNA and protein. Furthermore, we find increased expression of JMJD1A and JMJD2B in renal cancer cells that have lost the von Hippel Lindau tumor suppressor protein VHL and therefore display a deregulated expression of hypoxia-inducible factor. Studies on ectopically expressed JMJD1A and JMJD2B indicate that both proteins retain their histone lysine demethylase activity in hypoxia and thereby might impact the hypoxic gene expression program.
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Cites
1 retracted
Lysyl oxidase is essential for hypoxia-induced metastasis
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HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
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Cited by
KDM4/JMJD2 Histone Demethylases: Epigenetic Regulators in Cancer Cells
Berry, W. L., & Janknecht, R. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4300 · Cited by 447
Metabolic Shifts in Immunity and Inflammation
Kominsky, D. J., Campbell, E. L., & Colgan, S. P. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903002 · Cited by 416
Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer
Schödel, J., Grampp, S., Maher, E. R., Moch, H., Ratcliffe, P. J., Russo, P., & Mole, D. R. (2016) · European Urology · doi:10.1016/j.eururo.2015.08.007 · Cited by 405
Krieg, A. J., Rankin, E. B., Chan, D., Razorenova, O., Fernandez, S., & Giaccia, A. J. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00444-09 · Cited by 334
Epigenetic modulation of antitumor immunity for improved cancer immunotherapy
Dai, E., Zhu, Z., Wahed, S., Qu, Z., Storkus, W. J., & Guo, Z. S. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01464-x · Cited by 328
Metadata
- Authors
- Beyer, S., Kristensen, M. M., Jensen, K. S., Johansen, J. V., & Staller, P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 283
- Issue
- 52
- Pages
- 36542-36552
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2001401534
- Cited by
- 340
- References
- 85
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF. https://app.cochat.ai/papers/10.1074/jbc.m804578200
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- Beyer, S., Kristensen, M. M., Jensen, K. S., Johansen, J. V., & Staller, P. (2008). The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m804578200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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