Cited by 203Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchParkinson's Disease Mechanisms and Treatments

The DOI matches its Crossref record; 68 of the 82 references it cites were found in a registry or an index.

Amphetamine and methamphetamine differentially affect dopamine transporters in vitro and in vivo.

Open access

Goodwin, J. Shawn, Larson, Gaynor A., Swant, Jarod, Sen, Namita, Javitch, Jonathan A., Zahniser, Nancy R., De Felice, Louis J., Khoshbouei, Habibeh·2009·Journal of Biological Chemistry

DOI 10.1074/jbc.m805298200PMC PMC2631950

Open this paper in CoChat — free account Open PDF

Abstract

The psychostimulants d-amphetamine (AMPH) and methamphetamine (METH) release excess dopamine (DA) into the synaptic clefts of dopaminergic neurons. Abnormal DA release is thought to occur by reverse transport through the DA transporter (DAT), and it is believed to underlie the severe behavioral effects of these drugs. Here we compare structurally similar AMPH and METH on DAT function in a heterologous expression system and in an animal model. In the in vitro expression system, DAT-mediated whole-cell currents were greater for METH stimulation than for AMPH. At the same voltage and concentration, METH released five times more DA than AMPH and did so at physiological membrane potentials. At maximally effective concentrations, METH released twice as much [Ca(2+)](i) from internal stores compared with AMPH. [Ca(2+)](i) responses to both drugs were independent of membrane voltage but inhibited by DAT antagonists. Intact phosphorylation sites in the N-terminal domain of DAT were required for the AMPH- and METH-induced increase in [Ca(2+)](i) and for the enhanced effects of METH on [Ca(2+)](i) elevation. Calmodulin-dependent protein kinase II and protein kinase C inhibitors alone or in combination also blocked AMPH- or METH-induced Ca(2+) responses. Finally, in the rat nucleus accumbens, in vivo voltammetry showed that systemic application of METH inhibited DAT-mediated DA clearance more efficiently than AMPH, resulting in excess external DA. Together these data demonstrate that METH has a stronger effect on DAT-mediated cell physiology than AMPH, which may contribute to the euphoric and addictive properties of METH compared with AMPH.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1074/jbc.m805298200

Cites

68 of 68 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

FEBS Lett
Saraste, M., & Semenza, G. (2000) · doi:10.1016/s0014-5793(00)01734-8 · Cited by 7,456
Psychopharmacology
Silverstone, T. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.6.640 · Cited by 1,589
Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps.
Lytton, J., Westlin, M., & Hanley, M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47340-7 · Cited by 1,305
Neuropharmacology
Rosner, B. (1956) · The Yale Journal of Biology and Medicine · doi:10.1176/ajp.113.3.283-a · Cited by 1,262
Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin
Rothman, R. B., Baumann, M. H., Dersch, C. M., Romero, D. V., Rice, K. C., Carroll, F. I., & Partilla, J. S. (2000) · Synapse · doi:10.1002/1098-2396(20010101)39:1 · Cited by 944
Plasma membrane monoamine transporters: structure, regulation and function
Torres, G. E., Gainetdinov, R. R., & Caron, M. G. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1008 · Cited by 936
Profound neuronal plasticity in response to inactivation of the dopamine transporter
Jones, S. R., Gainetdinov, R. R., Jaber, M., Giros, B., Wightman, R. M., & Caron, M. G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.4029 · Cited by 712
Mechanisms of Amphetamine Action Revealed in Mice Lacking the Dopamine Transporter
Jones, S. R., Gainetdinov, R. R., Wightman, R. M., & Caron, M. G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-06-01979.1998 · Cited by 626
Molecular characterization of the dopamine transporter.
Giros, B., & Caron, M. (1993) · TIPS - Trends in Pharmacological Sciences · doi:10.1016/0165-6147(93)90029-j · Cited by 582
Monoamine transporters and psychostimulant drugs.
Rothman, R., & Baumann, M. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.054 · Cited by 509

Flagged first, then by citations

Show all 82 references

14 of the 82 references couldn’t be matched to a known paper.

Research works printed but not linked: 7

Fischer, 1976, Proc. West Pharmacol. Soc., 19, 179
Jones, 1998, Proc. Natl. Acad. Sci. U. S. A., 95, 4029
Hastrup, 2001, Proc. Natl. Acad. Sci. U. S. A., 98, 10055
Kahlig, 2005, Proc. Natl. Acad. Sci. U. S. A., 102, 3495
Carvelli, 2008, Proc. Natl. Acad. Sci. U. S. A., 105, 14192
Carvelli, 2004, Proc. Natl. Acad. Sci. U. S. A., 101, 16046
Salahpour, 2008, Proc. Natl. Acad. Sci. U. S. A., 105, 4405

Sorted by citations

Items 101–171 of 171

CART modulates the effects of levodopa in rat model of Parkinson's disease.
Upadhya, M. A., Shelkar, G., Subhedar, N., & Kokare, D. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.12.031 · Cited by 13
Brain Histamine N-Methyltransferase As a Possible Target of Treatment for Methamphetamine Overdose
Kitanaka, J., Kitanaka, N., Hall, F., Uhl, G., & Takemura, M. (2016) · Drug Target Insights · doi:10.4137/dti.s38342 · Cited by 13
Effects of 7-day continuous d-amphetamine, methylphenidate, and cocaine treatment on choice between methamphetamine and food in male rhesus monkeys
Schwienteck, K. L., & Banks, M. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.08.022 · Cited by 13
“Given potential differences between amphetamine and methamphetamine interactions at the dopamine transporter (Goodwin et al., 2009), there may also be differential treatment sensitivity between these two drug-dependent populations.”
Background
Methamphetamine regulation of activity and topology of ventral midbrain networks
Miller, D. R., Lebowitz, J., Guenther, D., Refowich, A. J., Hansen, C. A., Maurer, A. P., & Khoshbouei, H. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222957 · Cited by 12
Self-citation
Discriminative stimulus effects of cocaine and amphetamine in rats following developmental exposure to polychlorinated biphenyls (PCBs)
Sable, H. J. K., Monaikul, S., Poon, E., Eubig, P. A., & Schantz, S. L. (2010) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2010.10.003 · Cited by 13
“It has been reported that the amphetamine-induced reversal of the DAT which results in DA efflux depends on an increase in the concentration of intracellular calcium stores ([Ca]i) (Gnegy et al., 2004; Goodwin et al., 2009;Khoshbouei et al., 2004).”
Background
Buprenorphine reduces methamphetamine intake and drug seeking behavior via activating nociceptin/orphanin FQ peptide receptor in rats
Wang, F., Shen, W.-W., Cai, Y.-J., Zhang, X., Du, H., Lai, M., Liu, H.-F., Kohli, E., & Zhou, W.-H. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.983595 · Cited by 11
“N/OFQ and its NOP receptor are widely distributed in brain regions such as the ventral tegmental area (VTA) and the NAc, where both are largely co-expressed and may be involved in the control of drug dependence (24).”
BackgroundInfluential
Prolonged increase in ser31 tyrosine hydroxylase phosphorylation in substantia nigra following cessation of chronic methamphetamine
Salvatore, M. F., Nejtek, V. A., & Khoshbouei, H. (2018) · NeuroToxicology · doi:10.1016/j.neuro.2018.05.003 · Cited by 11
“Therefore, as chronic exposure of the DAT to MA would conceivably predispose the nigrostriatal somatodendritic compartment to continual DA efflux (Khoshbouei et al., 2003; Goodwin et al., 2009), the burden to replenish lost DA stores in the SN may activate signaling mechanisms by which ser31 is increased.”
Self-citation
Methamphetamine-Associated Cardiomyopathy: Addressing the Clinical Challenges.
Thoi, F., Scherer, D., Kaye, D., Sanders, P., & Stokes, M. (2022) · Heart, Lung and Circulation · doi:10.1016/j.hlc.2021.12.015 · Cited by 10
Epigenetic Regulation of the Ontogenic Expression of the Dopamine Transporter
Green, A. L., Eid, A., Zhan, L., Zarbl, H., Guo, G. L., & Richardson, J. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01099 · Cited by 10
Relationship between discriminative stimulus effects and plasma methamphetamine and amphetamine levels of intramuscular methamphetamine in male rhesus monkeys
Banks, M., Smith, D. A., Kisor, D., & Poklis, J. L. (2015) · Pharmacology, Biochemistry and Behavior · doi:10.1016/j.pbb.2015.12.001 · Cited by 10
“, 2010), and pigeons (Li and McMillan, 2001) and consistent with a shared pharmacological mechanism between methamphetamine and amphetamine (Goodwin et al., 2009).”
Background
Adolescent exposure to cocaine, amphetamine, and methylphenidate cross-sensitizes adults to methamphetamine with drug- and sex-specific effects
Shanks, R. A., Ross, J. M., Doyle, H. H., Helton, A., Picou, B. D., Schulz, J., Tavares, C., Bryant, S., Dawson, B. L., & Lloyd, S. A. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.12.002 · Cited by 31
Effect of insulin deficiency on the rewarding properties of methamphetamine in streptozotocin-induced diabetic rats.
Bayat, A.-H., & Haghparast, A. (2015) · Pharmacology, Biochemistry and Behavior · doi:10.1016/j.pbb.2014.11.008 · Cited by 10
“METH has a stronger effect on DAT-mediated cell physiology than AMPH, whichmay contribute to the euphoric and addictive characteristics of METH compared to amphetamine (AMPH) (Goodwin et al., 2009).”
Effect of Chaihu-jia-Longgu-Muli decoction on withdrawal symptoms in rats with methamphetamine-induced conditioned place preference
Li, Z.-F., Qi, Y.-C., Liu, K., Cao, Y., Zhang, H., Song, C.-H., & Deng, H. (2021) · Bioscience Reports · doi:10.1042/bsr20211376 · Cited by 9
Methamphetamine induces a low dopamine transporter expressing immunophenotype without altering total number of peripheral immune cells
Gopinath, A., Riaz, T., Miller, E., Phan, L., Smith, A. R., Syed, O., Franks, S., Martinez, L. R., & Khoshbouei, H. (2023) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13838 · Cited by 8
“1,4 7 METH users frequently experience formica-tion, a sensation that feels like insects crawling on or beneath the skin.”
BackgroundSelf-citation
Epigenetic Landscape of Methamphetamine Use Disorder
Cadet, J., & Jayanthi, S. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210524111915 · Cited by 8
“Methamphetamine causes neurotransmitter release by reversing monoamine transport [13-15] subsequently increasing the levels of norepinephrine and dopamine in the synaptic cleft, as measured by microdialysis [16, 17].”
Effects of Lisdexamfetamine, a Prodrug of D-Amphetamine, on Locomotion, Spatial Cognitive Processing and Neurochemical Profiles in Rats: A Comparison With Immediate-Release Amphetamine
Jian-min, C., Zhi-yuan, W., Shi-xuan, W., Rui, S., Ning, W., & Jin, L. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.885574 · Cited by 7
“5 mg/kg produced the lasting increased locomotion from 60 to 180 min after administration (two-way ANOVA with one repeated measurement: main effect of time: F(11,38) = 25.”
BackgroundMethod
Methamphetamine and the brain: Emerging molecular targets and signaling pathways involved in neurotoxicity
Rashidi, S. K., Khodagholi, F., Rafie, S., Kashipazha, D., Safarian, H., Khoshnam, S. E., & Dezfouli, M. A. (2024) · Toxin Reviews · doi:10.1080/15569543.2024.2360425 · Cited by 8
Does chronic use of amphetamine-type stimulants impair interference control? – A meta-analysis
Opitz, A., Petasch, M.-S., Klappauf, R., Kirschgens, J., Hinz, J. R., Dittmann, L., Dathe, A. S., Quednow, B. B., Beste, C., & Stock, A. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.105020 · Cited by 6
iTat transgenic mice exhibit hyper-locomotion in the behavioral pattern monitor after chronic exposure to methamphetamine but are unaffected by Tat expression
Ayoub, S. M., Kenton, J. A., Milienne-Petiot, M., Deben, D., Achim, C., Geyer, M., Perry, W., Grant, I., Young, J., & Minassian, A. (2022) · Pharmacology, Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173499 · Cited by 7
Analysis of striatum and brain levels reveals sex differences in conversion of methamphetamine to amphetamine in mice.
Jaehne, E., Smith, J. D., & van den Buuse, M. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136722 · Cited by 7
Structural optimizations and bioevaluation of N-H aporphine analogues as Gq-biased and selective serotonin 5-HT2C receptor agonists
Mao, Q., Zhang, B., Tian, S., Qin, W., Chen, J., Huang, X., Ye, X., Yang, H., Zhen, X.-C., Shui, W., et al. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.105795 · Cited by 8
Treatment outcome, cognitive function, and psychopathology in methamphetamine users compared to other substance users
Behle, N., Kamp, F., Proebstl, L., Hager, L., Riebschläger, M., Schacht-Jablonowsky, M., Hamdorf, W., Neumann, S., Krause, D., Manz, K., et al. (2021) · World Journal of Psychiatry · doi:10.5498/wjp.v12.i7.944 · Cited by 7
Allosterically Potentiated α7 Nicotinic Acetylcholine Receptors: Reduced Calcium Permeability and Current-Independent Control of Intracellular Calcium
Miller, D. R., Khoshbouei, H., Garai, S., Cantwell, L., Stokes, C. A., Thakur, G. A., & Papke, R. L. (2020) · Molecular Pharmacology · doi:10.1124/molpharm.120.000012 · Cited by 14
Self-citation
Phospho-specific antibodies targeting the amino terminus of the human dopamine transporter
Karam, C. S., Sen, N., & Javitch, J. (2017) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2017.05.003 · Cited by 7
“Moreover, we and others have demonstrated that phosphorylation of serines in the distal amino (N) terminus of DAT is required for efflux (Fog et al., 2006; Goodwin et al., 2009; Khoshbouei et al., 2004; Ramamoorthy et al., 2011), but not for uptake activity, inhibitor”
Self-citation
Contrasting changes in extracellular dopamine and glutamate along the rostrocaudal axis of the anterior cingulate cortex of the rat following an acute d-amphetamine or dopamine challenge
Ash, E. S., Heal, D. J., & Stanford, S. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.04.003 · Cited by 7
Amphetamine and Methamphetamine Have a Direct and Differential Effect on BV2 Microglia Cells
Shanks, R., Anderson, J., Taylor, J., & Lloyd, S. (2012) · Bulletin of experimental biology and medicine · doi:10.1007/s10517-012-1919-x · Cited by 7
Adolescent vulnerability to methamphetamine: Dose-related escalation of self-administration and cue extinction deficits
Luikinga, S. J., Madsen, H. B., Zbukvic, I., Perry, C. J., Lawrence, A. J., & Kim, J. H. (2025) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2025.112599 · Cited by 6
Environmental enrichment and sex, but not n-acetylcysteine, alter extended-access amphetamine self-administration and cue-seeking
Fort, T. D., Azuma, M. C., Laux, D. A., & Cain, M. E. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115261 · Cited by 7
Single Dose of Amphetamine Induces Delayed Subregional Attenuation of Cholinergic Interneuron Activity in the Striatum
Ztaou, S., Oh, S. J., Tepler, S., Fleury, S., Matamales, M., Bertran‐Gonzalez, J., Chuhma, N., & Rayport, S. (2021) · eNeuro · doi:10.1523/eneuro.0196-21.2021 · Cited by 52
“…effect on ChIs, a higher dose of a more potent psychostimulant appears to be required; a single high- September/October 2021, 8(5) ENEURO.0196-21.2021 eNeuro.org dose (30mg/kg) of methamphetamine was found to induce a loss of 29% of ChIs in the dorsal Str (Zhu et al., 2006; Goodwin et al., 2009).”
BackgroundInfluential
Association of sigma‐1 receptor with dopamine transporter attenuates the binding of methamphetamine via distinct helix–helix interactions
Xu, L., & Chen, L. Y. (2021) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13841 · Cited by 7
“The binding of METH to DAT disrupts DA transport by DAT and enhances the synaptic concentration of DA consequently (Goodwin et al., 2009).”
Background
Effect of a binge‐like dosing regimen of methamphetamine on dopamine levels and tyrosine hydroxylase expressing neurons in the rat brain
Santos, A. M. D. S., Kelly, J., Dockery, P., & Doyle, K. (2019) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.10.003 · Cited by 6
An acute, epitope‐specific modification in the dopamine transporter associated with methamphetamine‐induced neurotoxicity
Fricks-Gleason, A. N., German, C. L., Hoonakker, A. J., Friend, D. M., Ganesh, K., Carver, A. S., Hanson, G., Fleckenstein, A., & Keefe, K. (2016) · Synapse · doi:10.1002/syn.21891 · Cited by 6
“It has been shown that the majority of DAT phosphorylation occurs on one of six N-terminal serine residues (Foster et al., 2002), and that METH stimulates DAT phosphorylation in vitro (Cervinski et al., 2005; Goodwin et al., 2009; Khoshbouei et al., 2004).”
Background
Sub-chronic nicotine exposure influences methamphetamine self-administration and dopamine overflow in a sex-and genotype-dependent manner in humanized CHRNA6 3′-UTR SNP (rs2304297) adolescent rats
Carreño, D., Facundo, A., Cardenas, A. M., & Lotfipour, S. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1445303 · Cited by 6
Psychostimulants and social behaviors
Cid-Jofré, V., Bahamondes, T., Correa, A. Z., Arias, I. A., Reyes-Parada, M. I., & Renard, G. M. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1364630 · Cited by 6
Identification of Critical Residues in the Carboxy Terminus of the Dopamine Transporter Involved in the G Protein βγ-Induced Dopamine Efflux
Pino, J., Núñez-Vivanco, G., Hidalgo, G., Reyes-Parada, M., Khoshbouei, H., & Torres, G. E. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.642881 · Cited by 5
“Amperometry HEK-YFP-DAT cells were preloaded with DA as described previously (Goodwin et al., 2009; Roth et al., 2013; Sambo et al., 2018).”
MethodSelf-citation
Time and region-dependent manner of increased Brain Derived Neurotrophic Factor and TrkB in rat brain after binge-like methamphetamine exposure.
Santos, A. M. D. S., Gorman, A. M., Kelly, J., & Doyle, K. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134606 · Cited by 5
“Goodwin and colleagues (2) have shown that MA induces the release of 5 times more dopamine than amphetamine, which is responsible for the euphoric and addictive properties of MA.”
Background
The role of striatal G&agr;q/11 protein in methamphetamine‐induced behavioral sensitization in mice
Lee, K.-W., Kim, K., Kim, H.-C., Lee, S.-Y., & Jang, C. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.003 · Cited by 5
“Furthermore, PKC activation has been connected to DAT-mediated DA release, and PKC inhibitors have been shown to block AMPH-mediated DA release in rat striata [48–50].”
Influential
SUBSTITUCIÓN ASIMÉTRICA ENTRE METANFETAMINA Y ANFETAMINA: ESTUDIO DE DISCRIMINACIÓN DE DROGAS ASYMMETRIC SUBSTITUTION BETWEEN METHAMPHETAMINE AND AMPHETAMINE: STUDY OF DRUG DISCRIMINATION
Miranda, F., Cedillo-Ildefonso, B., Jiménez, J. C., Bedolla-Núñez, G., & Torres-Rodríguez, S. (2011) · Revista Mexicana de Análisis de la Conducta · doi:10.5514/rmac.v37.i1.24685 · Cited by 5
The Synthetic Opioid Isotonitazene Induces Locomotor Activity and Reward Effects through Modulation of the Central Dopaminergic System in Mice
Tomiyama, K.-I., & Funada, M. (2025) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2025.117361 · Cited by 4
Amphetamines in child medicine: a review of ClinicalTrials.gov
Alalalmeh, S. O., Hegazi, O. E., Shahwan, M., Alshehri, F., Ashour, A. M., Algarni, A. S., & Alorfi, N. M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1280562 · Cited by 4
Unraveling the Mysteries of Mental Illness With Psilocybin
Sottile, R., Singh, H., Weisman, A., & Vida, T. (2022) · Cureus · doi:10.7759/cureus.25414 · Cited by 4
“Similar to the dramatic increase in potency caused by the addition of a single methyl (methamphetamine) group to amphetamine, a remarkable change in physiological effect occurs from the addition of two aminomethyl groups and one indole hydroxyl group to serotonin, producing psilocin (Figure 1) [58].”
Background
Differential effects of chronic adolescent glucocorticoid or methamphetamine on drug-induced locomotor hyperactivity and disruption of prepulse inhibition in adulthood in mice
Schonfeld, L., Jaehne, E. J., Ogden, A. R., Spiers, J. G., Hogarth, S. J., & van den Buuse, M. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110552 · Cited by 5
Dopamine sensitization by methamphetamine treatment prior to instrumental training delays the transition into habit in female rats
Schoenberg, H. L., Evans, C., Bausch, L., Wootton, A., Kirshenbaum, A. P., & Toufexis, D. J. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113636 · Cited by 4
Cannabinoid CB1 receptor mediates METH-induced electrophysiological and morphological alterations in cerebellum Purkinje cells
Ramshini, E., Sheykhzade, M., Dabiri, S., & Shabani, M. (2020) · Human and Experimental Toxicology · doi:10.1177/0960327120975448 · Cited by 4
A history of ethanol drinking increases locomotor stimulation and blunts enhancement of dendritic dopamine transmission by methamphetamine
Tschumi, C., Daszkowski, A. W., Sharpe, A. L., Trzeciak, M., & Beckstead, M. (2019) · Addiction Biology · doi:10.1111/adb.12763 · Cited by 4
“However, extracellular levels of dopamine remain high, likely due to efflux of dopamine through DAT.(34) While methamphetamine has many cellular actions at high concentrations, the decreased methamphetamine‐induced enhancement of D2‐IPSC amplitudes reported here may be a result of increased action at VMAT2, with deple…”
BackgroundInfluential
New Findings on the Sensitivity of Free-Operant Timing Behaviour to 5-Hydroxytryptamine Receptor Stimulation
Body, S., Cheung, T. H. C., Bezzina, G., Hampson, C. L., Fone, K., Bradshaw, C., Glennon, J. C., & Szabadi, E. (2014) · doi:10.1163/22134468-00002024 · Cited by 4
The missing link: TNF-α as a unifying mechanism in methamphetamine-induced neuronal dysfunction and blood-brain barrier compromise
da Silva, M. C. M., de Oliveira, A. C. P., Candelario‐Jalil, E., & Khoshbouei, H. (2025) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2025.578736 · Cited by 4
Self-citation
Interaction of Brain-Derived Neurotrophic Factor with the Effects of Chronic Methamphetamine on Prepulse Inhibition in Mice Is Independent of Dopamine D3 Receptors
Hogarth, S. J., Jaehne, E. J., Xu, X., Schwarz, Q., & van den Buuse, M. (2023) · Biomedicines · doi:10.3390/biomedicines11082290 · Cited by 2
“However, it is possible that these studies are not comparable to the present results based on differences between the effects of METH and D-amphetamine, such as differential dopamine release and DAT modulation [29,63].”
BackgroundResult
Methcathinone decreases dopamine transporter function: Role of protein kinase C
Magee, C., Le, B. D., Siripathane, Y. H., Wilkins, D., Hanson, G., & Fleckenstein, A. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15483 · Cited by 3
Molecular Docking Studies of Methamphetamine and Amphetamine- Related Derivatives as an Inhibitor against Dopamine Receptor
Foroughi, K., Khaksari, M., & Shayannia, A. (2018) · Current Computer - Aided Drug Design · doi:10.2174/1573409915666181204144411 · Cited by 5
Replacement treatment during extinction training with the atypical dopamine uptake inhibitor, JHW-007, reduces relapse to methamphetamine seeking.
Dassanayake, A. F., & Canales, J. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.02.025 · Cited by 3
The Psychopharmacology of Hallucinations: Ironic Insights into Mechanisms of Action
Lowe, N. G., Rapagnani, M. P., Mattei, C., & Stahl, S. M. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4121-2_24 · Cited by 3
Activation of lateral hypothalamic melanin-concentrating hormone neurons mediates sex-specific patterns of methamphetamine self-administration in rats.
Suarez, M., Kuebler, I. R. K., Schneider, H. M., Vollan, J. D., Hubbard, N. A., & Wakabayashi, K. T. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.116002 · Cited by 2
“Chemical Seduction”: a narrative review of the complex impact of recreational drugs on sexual function
Meller, N., & Kitrey, N. D. (2025) · International Journal of Impotence Research · doi:10.1038/s41443-025-01194-4 · Cited by 2
“The mechanism of action of synthetic cathinones involves disrupting the normal function of plasma membrane transporters for norepinephrine, dopamine, and serotonin by reversing transporter ﬂ ux, blocking reuptake, or stimulating presynaptic release [57, 59].”
How does drug abuse affect outcomes after trauma? A trauma quality improvement program study.
Rafieezadeh, A., Prabhakaran, K., Kirsch, J., Jose, A., & Zangbar, B. (2025) · American Journal of Surgery · doi:10.1016/j.amjsurg.2025.116332 · Cited by 2
Transient receptor potential ankyrin 1 channel modulates the abuse‐related mechanisms of methamphetamine through interaction with dopamine transporter
Hur, K., Lee, Y., Donio, A. L., Kim, S., Lee, B., Seo, J., Kundu, D., Kim, K., Kohut, S. J., Lee, S., et al. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16370 · Cited by 3
“…METH (1) interferes with the reuptake of dopamine through the dopamine transporter (DAT), resulting in excessive dopamine in the synaptic cleft (Goodwin et al., 2009); (2) inhibits the storage of dopamine in intracellular vesicles through the vesicular monoamine transporter , thereby…”
Background
Optogenetically-induced multimerization of the dopamine transporter increases uptake and trafficking to the plasma membrane
Ingram, S., Rana, T., Manson, A. M., Yayah, F. M., Jackson, E. G. B., Anderson, C. D., Davids, B., & Goodwin, J. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100787 · Cited by 2
Self-citation
Could Clinical Use of Stimulant Medications Increase Risk for Parkinson's Disease or Other Neurological Sequelae? A Review of the Evidence
Baumeister, A. (2017) · Journal of pharmacology & clinical research · doi:10.19080/jpcr.2017.03.555618 · Cited by 2
“Methamphetamine is more effective than d-amphetamine in releasing striatal dopamine [30].”
Background
Single cell measurement of dopamine release with simultaneous voltage-clamp and amperometry.
Saha, K., Swant, J., & Khoshbouei, H. (2012) · Journal of Visualized Experiments · doi:10.3791/3798 · Cited by 2
Self-citation
Association between cerebrospinal fluid dopamine concentrations and catechol- O -methyltransferase gene polymorphisms in forensic autopsy cases of methamphetamine abusers
Matsusue, A., Ishikawa, T., Michiue, T., Waters, B., Hara, K., Kashiwagi, M., Takayama, M., Ikematsu, N., & Kubo, S. (2016) · Forensic Science International · doi:10.1016/j.forsciint.2016.12.002 · Cited by 2
Chemistry to cognition: Therapeutic potential of (m-CF3-PhSe)2 targeting rats' striatum dopamine proteins in amphetamine dependence.
Dahleh, M. M. M., Muller, S. G., Klann, I. P., Marques, L. S., da Rosa, J. L., Fontoura, M., Burger, M. E., Nogueira, C. W., Prigol, M., Boeira, S., et al. (2024) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111238 · Cited by 1
Prenatal and postnatal methamphetamine exposure alters prefrontal cortical gene expression and behavior in mice
Adeniyi, P., Adeyelu, T. T., Shrestha, A., Liu, C.-C., & Lee, C. C. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2024.1286872 · Cited by 1
“Moreover, methamphetamine can also facilitate the non-vesicular release of dopamine via dopamine transporters (Bennett et al., 1998; Goodwin et al., 2009; Xie and Miller, 2009).”
Background
Amphetamine und Crystal Meth: Epidemiologie, Symptomatik und Therapie konsumassoziierter Störungen
Quednow, B., & Dürsteler, K. M. (2022) · Suchttherapie · doi:10.1055/a-2451-0277 · Cited by 1
“Insge - samt hat Methamphetamin eine stärkere Wirkung auf die Dopaminausschüttung als Amphetamin, was zu den stär-ker euphorisierenden Eigenschaften von Methampheta-min beitragen könnte [19].”
The sleep-wake circuit plays a role in temporal distortions.
Reggia, J. A., & Teymourlouei, A. (2026) · Consciousness and Cognition · doi:10.1016/j.concog.2026.104145
Amphetamine produces enhanced behavioral responding in sensitized male rats: Parallel changes in AMPA receptor surface expression and PKC signaling in the NAcc
Mascia, P., Brown, J., Li, D., Bubula, N., Riazanski, V., & Vezina, P. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111837
Psychopharmacology of Methamphetamine in Relation to the United Kingdom Sentencing Guidance: Comparative Analysis with Amphetamine, Cocaine and Heroin
Guirguis, A., Giorgetti, A., Seo, J., Corkery, J., & Schifano, F. (2026) · Brain Science · doi:10.3390/brainsci16060602
“…methamphetamine appears to generate a more intense and prolonged dopaminergic burden and is associated, particularly under common high-intensity pa tt erns of use, with greater risk of repeated use, dependence, psychosis and neurotoxicity relative to amphetamine [5,7].”
DECODING SOLVATION: ADVANCED COMPUTATIONAL ANALYSIS OF AMPHETAMINE AND METHAMPHETAMINE HYDRATION
Peter, M., Maharajan, R., Durai, S., Iyappan, S., Azath, A. M., & Jebaraj, J. (2026) · Total Chemistry · doi:10.1016/j.totche.2026.100026
Neurochemical alterations in monoaminergic systems induced by excessive sucrose consumption from the juvenile period to adolescence in mice.
Choe, W.-H., Kim, Y.-J., Lee, K.-A., & Lee, Y.-A. (2025) · Neuroscience Letters · doi:10.1016/j.neulet.2025.138308
Central nervous system stimulants
Kaleta, E. (2020) · Toxicology Cases for the Clinical and Forensic Laboratory · doi:10.1016/b978-0-12-815846-3.00014-4
Structure-Activity Relationship Studies of Synthetic Cathinones and Related Agents
Davies, R. A. (2019) · doi:10.25772/tzsa-0396
The Pharmacology of an Agonist Medication to Treat Stimulant Use Disorder
Johnson, A. R. (2017) · doi:10.25772/wsbg-p750

Authors: Goodwin, J. S., Larson, G. A., Swant, J., Sen, N., Javitch, J. A., Zahniser, N. R., De Felice, L. J., & Khoshbouei, H.
Affiliations: Meharry Medical College (US)
University of Colorado Denver (US)
Columbia University (US)
Corresponding author: Khoshbouei, Habibeh
ORCID: Goodwin, J. Shawn
Javitch, Jonathan A.
Khoshbouei, Habibeh
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2009-01
Volume: 284
Issue: 5
Pages: 2978-2989
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m805298200
PMC: PMC2631950
OpenAlex: W2025188861
Cited by: 203
References: 82
Citations by year: 2026: 4 · 2025: 14 · 2024: 15 · 2023: 9 · 2022: 19 · 2021: 17 · 2020: 8 · 2019: 10 · 2018: 10 · 2017: 10 · 2016: 12 · 2015: 14 · 2014: 17 · 2013: 6 · 2012: 13
FWCI: 3.60
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 4306 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation (0642188)
National Institutes of Health (DA012408, DA004216, DA022413)
National Heart, Lung, and Blood Institute (T32HL076133, HL076133)
National Institute on Drug Abuse (DA012408, P01DA012408, DA021471, DA015050, K05DA022413, DA-022413, DA-004216, K05DA015050, R01DA026947, DA06338, R24DA021471)
National Cancer Institute (U54CA091408, U54CA91408)
National Institute of Neurological Disorders and Stroke (U54NS041071, NS034075, R01NS034075)
National Center for Research Resources (G12RR003032, U54RR019192, G12-RR03032)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords: amphetamine, methamphetamine, dopamine transporter, dopamine release, psychostimulants, intracellular calcium, N-terminal phosphorylation, calcium/calmodulin-dependent protein kinase II, protein kinase C, nucleus accumbens, dopamine clearance, drug addiction
MeSH terms: Amphetamine, Animals, Bacterial Proteins, Calcium, Cell Line, Dopamine, Humans, Luminescent Proteins, Male, Methamphetamine, Nucleus Accumbens, Rats, Sprague-Dawley, Patch-Clamp Techniques, Dopamine Plasma Membrane Transport Proteins, Rats, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Amphetamine and methamphetamine differentially affect dopamine transporters in vitro and in vivo.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Metadata

Record

About these checks