Rod and Cone Visual Pigments and Phototransduction through Pharmacological, Genetic, and Physiological Approaches
Open accessAbstract
Activation of the visual pigment by light in rod and cone photoreceptors initiates our visual perception. As a result, the signaling properties of visual pigments, consisting of a protein, opsin, and a chromophore, 11-cis-retinal, play a key role in shaping the light responses of photoreceptors. The combination of pharmacological, physiological, and genetic tools has been a powerful approach advancing our understanding of the interactions between opsin and chromophore and how they affect the function of visual pigments. The signaling properties of the visual pigments modulate many aspects of the function of rods and cones, producing their unique physiological properties.
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A second, cone visual cycle occurs in Müller cells and serves cones with fast recycling necessary for their rapid dark adaptation and function in constant and bright illumination.
“There is a second, so called cone visual cycle, that occurs in the Müller cells. It serves cones with fast recycling, necessary for their rapid dark adaptation and function in constant and bright illumination [29,47,59,60,61,62].”
From The Role of Vitamin A in Retinal Diseases (2022) · cites this paper as [59]
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References 95 · Cited by 114
- Authors
- Kefalov, V. J.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Kefalov, Vladimir J.
- ORCID
- Kefalov, Vladimir J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 287
- Issue
- 3
- Pages
- 1635-1641
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC3265844
- OpenAlex
- W2125739583
- Cited by
- 114
- References
- 95
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 7 · 2023: 7 · 2022: 11 · 2021: 5 · 2020: 11 · 2019: 8 · 2018: 8 · 2017: 4 · 2016: 8 · 2015: 9 · 2014: 8 · 2013: 11 · 2012: 3
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (EY021126, P30EY002687, R01EY019312, R24EY021126, EY019312, EY002687)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- rod photoreceptors, cone photoreceptors, visual pigments, opsin, 11-cis-retinal, phototransduction, light signaling, retinal chromophore
- MeSH terms
- Animals, Humans, Retinaldehyde, Vision, Ocular, Signal Transduction, Retinal Rod Photoreceptor Cells, Retinal Cone Photoreceptor Cells, Opsins
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