The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Cancer Metabolism and Elevated O-GlcNAc in Oncogenic Signaling
Open accessAbstract
O-Linked -N-acetylglucosamine (O-GlcNAc) is a carbohydrate post-translational modification on hydroxyl groups of serine and/or threonine residues of cytosolic and nuclear proteins.Analogous to phosphorylation, O-GlcNAcylation plays crucial regulatory roles in cellular signaling.Recent work indicates that increased O-GlcNAcylation is a general feature of cancer and contributes to transformed phenotypes.In this minireview, we discuss how hyper-O-GlcNAcylation may be linked to various hallmarks of cancer, including cancer cell proliferation, survival, invasion, and metastasis; energy metabolism; and epigenetics.We also discuss potential therapeutic modulation of O-GlcNAc levels in cancer treatment.* This is the fifth article in the Minireview Series on the Thirtieth Anniversary of Research on O-GlcNAcylation of Nuclear and Cytoplasmic Proteins: Nutrient Regulation of Cellular Metabolism and Physiology by O-GlcNAcylation.
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Cites
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Background
Cited by
Glycosylation in cancer: mechanisms and clinical implications
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Hallmarks of glycosylation in cancer
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Glycosylation: mechanisms, biological functions and clinical implications
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O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth
Nie, H., Ju, H., Fan, J., Shi, X., Cheng, Y., Cang, X., Zheng, Z., Duan, X., & Yi, W. (2020) · Nature Communications · doi:10.1038/s41467-019-13601-8 · Cited by 346
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Metadata
- Authors
- Ma, Z., & Vosseller, K.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 289
- Issue
- 50
- Pages
- 34457-34465
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2034827327
- Cited by
- 212
- References
- 10
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ma, Z., & Vosseller, K. (2014). Cancer Metabolism and Elevated O-GlcNAc in Oncogenic Signaling. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.r114.577718
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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