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Mechanisms in Eukaryotic Mismatch Repair
Open accessAbstract
Inactivation of the human mismatch repair system confers a large increase in spontaneous mutability and a strong predisposition to tumor development. Mismatch repair provides several genetic stabilization functions; it corrects DNA biosynthetic errors, ensures the fidelity of genetic recombination, and participates in the earliest steps of checkpoint and apoptotic responses to several classes of DNA damage (see Refs. 1–3 for recent reviews). Defects in this pathway are the cause of typical and atypical hereditary nonpolyposis colon cancer (4) but may also play a role in the development of 15–25% of sporadic tumors that occur in a number of tissues (5).
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Citations
Cited by
PCNA, the Maestro of the Replication Fork
Moldovan, G.-L., Pfander, B., & Jentsch, S. (2007) · Cell · doi:10.1016/j.cell.2007.05.003 · Cited by 1,796
“Starting from this nick or gap, and perhaps also from other nicks actively introduced by the MMR machinery, excision of the defective strand occurs (Modrich, 2006).”
DNA repair mechanisms in dividing and non-dividing cells
Iyama, T., & Wilson, D. M. (2013) · DNA Repair · doi:10.1016/j.dnarep.2013.04.015 · Cited by 697
Mechanisms of trinucleotide repeat instability during human development
McMurray, C. T. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2828 · Cited by 496
The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and Update
Alexeyev, M., Shokolenko, I., Wilson, G., & LeDoux, S. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012641 · Cited by 458
Minimizing the damage: repair pathways keep mitochondrial DNA intact
Kazak, L., Reyes, A., & Holt, I. J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3439 · Cited by 388
Metadata
- Authors
- Modrich, P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2006-10
- Volume
- 281
- Issue
- 41
- Pages
- 30305-30309
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2024946505
- Cited by
- 457
- References
- 0
- FWCI
- 9.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
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