The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Biological Functions of the Small Leucine-rich Proteoglycans: From Genetics to Signal Transduction
Open accessAbstract
The small leucine-rich proteoglycan (SLRP) family has significantly expanded in the past decade to now encompass five discrete classes, grouped by common structural and functional properties. Some of these gene products are not classical proteoglycans, whereas others have new and unique features. In addition to being structural proteins, SLRPs constitute a network of signal regulation: being mostly extracellular, they are upstream of multiple signaling cascades. They affect intracellular phosphorylation, a major conduit of information for cellular responses, and modulate distinct pathways, including those driven by bone morphogenetic protein/transforming growth factor beta superfamily members, receptor tyrosine kinases such as ErbB family members and the insulin-like growth factor I receptor, and Toll-like receptors. The wealth of mechanistic insights into the molecular and cellular functions of SLRPs has revealed both the sophistication of this family of regulatory proteins and the challenges that remain in uncovering the totality of their functions. This review is focused on novel biological functions of SLRPs with special emphasis on their protein cores, newly described genetic diseases, and signaling events in which SLRPs play key functions.
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Cites
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Targeted Disruption of Decorin Leads to Abnormal Collagen Fibril Morphology and Skin Fragility
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The Biology of the Small Leucine-rich Proteoglycans
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Cited by
The extracellular matrix at a glance
Frantz, C., Stewart, K. M., & Weaver, V. M. (2010) · Journal of Cell Science · doi:10.1242/jcs.023820 · Cited by 4,334
Extracellular Matrix Assembly: A Multiscale Deconstruction
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The regulatory roles of small leucine‐rich proteoglycans in extracellular matrix assembly
Chen, S., & Birk, D. E. (2013) · The FEBS Journal · doi:10.1111/febs.12136 · Cited by 378
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Metadata
- Authors
- Schaefer, L., & Iozzo, R. V.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 283
- Issue
- 31
- Pages
- 21305-21309
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2077684583
- Cited by
- 549
- References
- 56
- FWCI
- 13.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
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