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ENaC at the Cutting Edge: Regulation of Epithelial Sodium Channels by Proteases
Open accessAbstract
Epithelial Na+ channels facilitate the transport of Na+ across high resistance epithelia. Proteolytic cleavage has an important role in regulating the activity of these channels by increasing their open probability. Specific proteases have been shown to activate epithelial Na+ channels by cleaving channel subunits at defined sites within their extracellular domains. This minireview addresses the mechanisms by which proteases activate this channel and the question of why proteolysis has evolved as a mechanism of channel activation.
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Cited by
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Veiras, L. C., Girardi, A. C. C., Curry, J., Pei, L., Ralph, D. L., Tran, A., Castelo-Branco, R. C., Pastor-Soler, N., Arranz, C. T., Yu, A. S. L., et al. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2017030295 · Cited by 316
Exosomal GAPDH from Proximal Tubule Cells Regulate ENaC Activity
Jella, K. K., Yu, L., Yue, Q., Friedman, D., Duke, B. J., & Alli, A. A. (2016) · PLOS ONE · doi:10.1371/journal.pone.0165763 · Cited by 81
Reiner, J., Thiery, J., Held, J., Berlin, P., Skarbaliene, J., Vollmar, B., Jaster, R., Eriksson, P., Lamprecht, G., & Witte, M. (2022) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14791 · Cited by 24
Furukawa, Y., & Tagashira, I. (2023) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-023-02817-9 · Cited by 4
Metadata
- Authors
- Kleyman, T. R., Carattino, M. D., & Hughey, R. P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 284
- Issue
- 31
- Pages
- 20447-20451
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2021407435
- Cited by
- 292
- References
- 0
- FWCI
- 11.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kleyman, T. R., Carattino, M. D., & Hughey, R. P. (2009). ENaC at the Cutting Edge: Regulation of Epithelial Sodium Channels by Proteases. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.r800083200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
