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N-terminal acetylation and the N-end rule pathway control degradation of the lipid droplet protein PLIN2
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In HeLa, HEK293T, and HepG2 cells, MARCHF6 regulates the level of PLIN2, a lipid droplet-associated protein implicated in hepatic lipid metabolism.
“Furthermore, in HeLa, HEK293T, and HepG2 cells MARCHF6 was also reported to regulate the level of PLIN2, a lipid droplet (LD)-associated protein implicated in hepatic lipid metabolism [31,32].”
From Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis (2026) · cites this paper as [31]
MARCHF6 regulates proteasomal degradation of the LD-associated protein PLIN2.
“In lipid metabolism, MARCHF6 was shown to regulate the proteasomal degradation of the cholesterol biosynthesis enzymes SQLE, DHCR24, LDM, SC4MOL and SC5D [22,23,[25], [26], [27]], as well as of the LD-associated protein PLIN2 [31].”
From Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis (2026) · cites this paper as [31]
SQLE and PLIN2 are established MARCHF6 targets and proxies for its activity.
“In addition, SQLE and PLIN2, two established MARCHF6 targets and proxies for its activity [22,31], were more abundant in those mice (Figure 5D and Supplementary Fig. 5C).”
From Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis (2026) · cites this paper as [31]
SQLE and PLIN2 were more abundant in Marchf6LKO and Marchf6(-/-) livers.
“In addition, SQLE and PLIN2, two established MARCHF6 targets and proxies for its activity [22,31], were more abundant in those mice (Figure 5D and Supplementary Fig. 5C).”
From Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis (2026) · cites this paper as [31]
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Cited by
Sorted by citations
Sachdev, V., van Loon, N. M., Kingma, J., Ottenhoff, R., Tan, J. M. E., van den Berg, M., Duijst, S., Jongejan, A., Levels, J. H. M., Rensen, P. C. N., et al. (2026) · Molecular Metabolism · doi:10.1016/j.molmet.2026.102379 · Cited by 1
Metadata
- Authors
- Nguyen, K. T., Lee, C.-S., Mun, S.-H., Truong, N. T., Park, S. K., & Hwang, C.-S.
- ORCID
- Hwang, Cheol-Sang
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 294
- Issue
- 1
- Pages
- 379-388
- ISSN
- 0021-9258
- Cited by
- 89
- References
- 2
- Language
- en
- Funders
- Samsung Science & Technology Foundation (SSTF-BA1401–17)
- National Research Foundation of Korea (NRF) (NRF-2017R1A5A1015366)
- BK21 Plus Program (BK21 Plus Program)
- POSCO (POSCO Green Science and Innovation Grant)
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