Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2

Fred, Senem Merve; Laukkanen, Liina; Brunello, Cecilia A.; Vesa, Liisa; Göös, Helka; Cardon, Iseline; Moliner, Rafael; Maritzen, Tanja; Varjosalo, Markku; Casarotto, Plinio C.; Castrén, Eero

doi:10.1074/jbc.ra119.008837

Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2

Several antidepressant drugs activate tropomyosin-related kinase B (TRKB) receptor, but it remains unclear whether these compounds employ a common mechanism for TRKB activation. Here, using MS, we found that a single intraperitoneal injection of fluoxetine disrupts the interaction of several prot…