Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity

Heer, Collin D.; Sanderson, Daniel J.; Voth, Lynden S.; Alhammad, Yousef M.O.; Schmidt, Mark S.; Trammell, Samuel A.J.; Perlman, Stanley; Cohen, Michael S.; Fehr, Anthony R.; Brenner, Charles

doi:10.1074/jbc.ra120.015138

Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity

Poly(ADP-ribose) polymerase (PARP) superfamily members covalently link either a single ADP-ribose (ADPR) or a chain of ADPR units to proteins using NAD as the source of ADPR. Although the well-known poly(ADP-ribosylating) (PARylating) PARPs primarily function in the DNA damage response, many nonc…