Antidiabetic activity of a xanthone compound, mangiferin
Abstract
Mangiferin (MF) isolated from Anemarrhena asphodeloides Bunge rhizome, was tested for antidiabetic activity in KK-Ay mice, an animal model of type-2 diabetes. MF lowered the blood glucose level of KK-Ay mice 3 weeks after oral administration (p < 0.01). However, no effect on the blood glucose level in normal mice was seen, indicating that MF could be useful in treating type-2 diabetes. In addition, MF improved hyperinsulinemia and, on insulin tolerance test, reduced blood glucose levels of KK-Ay mice. From these findings, it seems likely that MF exerts its antidiabetic activity by decreasing insulin resistance.
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Mangiferin exerts significant antidiabetic, antihyperlipidemic and antiatherogenic effects in diabetic rat models.
“Similarly, Muruganandan et al (28), Miura et al (29,30) and Suman et al (31) verified that mangiferin exerted significant antidiabetic, antihyperlipidemic and antiatherogenic effects in diabetic rat models.”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [30]
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References 9 · Cited by 206
- Authors
- Miura, T., Ichiki, H., Hashimoto, I., Iwamoto, N., Kao, M., Kubo, M., Ishihara, E., Komatsu, Y., Okada, M., Ishida, T., & Tanigawa, K.
- Affiliations
- Suzuka University of Medical Science (JP)
- Tsumura (Japan) (JP)
- Venue
- Phytomedicine
- Publisher
- Elsevier BV
- Published
- 2001-01
- Volume
- 8
- Issue
- 2
- Pages
- 85-87
- ISSN
- 0944-7113 (ISSN-L)
- OpenAlex
- W2035609051
- Cited by
- 206
- References
- 9
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 5 · 2023: 11 · 2022: 9 · 2021: 6 · 2020: 7 · 2019: 11 · 2018: 12 · 2017: 11 · 2016: 21 · 2015: 9 · 2014: 20 · 2013: 8 · 2012: 8
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytomedicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
- Keywords
- mangiferin, xanthones, antidiabetic activity, type 2 diabetes, Anemarrhena asphodeloides, blood glucose, hyperinsulinemia, insulin resistance, insulin tolerance test, KK-Ay mice
- MeSH terms
- Administration, Oral, Animals, Blood Glucose, Diabetes Mellitus, Type 2, Disease Models, Animal, Glucosides, Hyperinsulinism, Hypoglycemic Agents, Insulin, Insulin Resistance, Male, Phytotherapy, Plant Extracts, Xanthenes, Magnoliopsida, Xanthones, Mice
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