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Effect of Latanoprost on Hair Growth in the Bald Scalp of the Stump-tailed Macacque: A Pilot Study
Open accessAbstract
Latanoprost, a selective FP prostanoid receptor agonist used in the treatment of glaucoma, has a hypertrichotic side effect. Using the macaque model of androgenetic alopecia, we examined the effect of latanoprost on hair growth. Eight monkeys were divided into 2 groups; one group received a daily topical application of 50 microg/ml of latanoprost for 5 months; a control group had a daily application of vehicle. For an additional 3 months, 2 monkeys from each group were given 500 microg/ml latanoprost, while the remaining monkeys continued with the previous treatment. Hair growth was evaluated by monthly photographs and phototricho-graphic analysis. Fifty microg/ml of latanoprost caused minimal hair growth. Latanoprost at 500 microg/ml induced moderate to marked hair regrowth with 5-10% conversion of vellus hairs to intermediary or terminal hairs. The vehicle group showed no effect. Further evaluation of latanoprost as an agent for treatment of human androgenetic alopecia is indicated.
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Animal studies revealed that bimatoprost can prolong the anagen duration and prolong the telogen-to-anagen transition phase, resulting in increased hair growth and length.
“Animal studies revealed that bimatoprost can prolong the anagen duration and further prolongs telogen to anegen transition phase. This results in increased hair growth and length.”
Bimatoprost has been shown in mouse models to increase hair bulb and papillae diameters and increase melanogenesis, resulting in increased hair thickness and pigmentation.
“Furthermore, bimatoprost had been shown in mouse models to increase the hair bulb and papillae diameters as well as increase melanogenesis which results in increased hair thickness and pigmentation [11, 12].”
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Zaky, M. S., Hashem, O. A., Mahfouz, S. M., & Elsaie, M. L. (2023) · Archives of Dermatological Research · doi:10.1007/s00403-023-02679-2 · Cited by 6
Metadata
- Authors
- Uno, H., Zimbric, M. L., Albert, D. M., & Stjernschantz, J.
- Affiliations
- University of Wisconsin–Madison (US)
- Venue
- Acta Dermato-Venereologica
- Published
- 2002-01-01
- Volume
- 82
- Issue
- 1
- Pages
- 7-12
- ISSN
- 0001-5555 (ISSN-L)
- OpenAlex
- W2005336760
- Cited by
- 42
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 5 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Acta Dermato Venereologica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (RR 00167, P51RR000167)
- Topics
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- latanoprost, androgenetic alopecia, hair regrowth, stump-tailed macaque, hypertrichosis, hair loss treatment
- MeSH terms
- Latanoprost, Administration, Topical, Alopecia, Animals, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Hair, Macaca, Male, Pilot Projects, Prostaglandins F, Synthetic, Random Allocation, Reference Values, Treatment Outcome
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