The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
The novel ischemia marker ‘ischemia‐modified albumin’ is increased in normal pregnancies
Open accessAbstract
The aim of this prospective case‐control study was to determine the change in serum maternal ischemia‐modified albumin (IMA) during normal pregnancies. A total of 117 pregnant (first trimester (n = 24), second trimester (n = 34), and third trimester (n = 35)) and non‐pregnant healthy women (n = 23) were included. Maternal serum IMA, Malondialdehyde (MDA), and albumin levels were measured. Compared with non‐pregnant women, the cross‐sectional mean IMA levels in pregnant women were significantly increased, while the mean serum MDA and albumin levels were significantly decreased throughout pregnancy. Furthermore, a significant negative correlation between serum IMA and albumin levels (r = −0.354, p<0.001) was found, and there was a weak positive correlation between serum albumin and MDA levels (r = 0.334, p<0.001). Serum IMA, which has recently been developed as a clinical marker of ongoing myocardial ischemia, appears to be elevated in normal pregnancy. This may be due to the physiologic oxidative stress state of pregnancy.
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“The inflammation present in pregnancy is associated with modest hypoalbuminemia, which progresses from the first to the third trimester and is paralleled by increased water content of the maternal interstitium.30, 110, 111”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [110]
Citations
Cites
Jauniaux, E., Watson, A., & Burton, G. (2001) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2001.111935 · Cited by 318
Bar‐Or, D., Curtis, G., Rao, N., Bampos, N., & Lau, E. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.01846.x · Cited by 299
Jauniaux, E., Gulbis, B., & Burton, G. J. (2003) · Placenta · doi:10.1053/plac.2002.0932 · Cited by 229
Lipid Peroxides and Related Radicals in Clinical Medicine
Yagi, K. (1994) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-1833-4_1 · Cited by 225
Levels of lipid peroxides in uncomplicated pregnancy: a review of the literature
Little, R. E., & Gladen, B. C. (1999) · Reproductive Toxicology · doi:10.1016/s0890-6238(99)00033-7 · Cited by 185
Albumin cobalt binding and ischemia modified albumin generation: An endogenous response to ischemia?
Lippi, G., Montagnana, M., & Guidi, G. C. (2005) · International Journal of Cardiology · doi:10.1016/j.ijcard.2005.03.040 · Cited by 112
The value of ischemia-modified albumin compared with d-dimer in the diagnosis of pulmonary embolism
Türedi, S., Gündüz, A., Menteşe, A., et al. (2008) · Respiratory Research · doi:10.1186/1465-9921-9-49 · Cited by 67
Ischemia Modified Albumin in Normal Pregnancy and Preeclampsia
van Rijn, B. B., Franx, A., Sikkema, J. M., et al. (2008) · Hypertension in Pregnancy · doi:10.1080/10641950701885147 · Cited by 62
Papageorghiou, A. T., Prefumo, F., Leslie, K., Gaze, D. C., Collinson, P. O., & Thilaganathan, B. (2008) · Human Reproduction · doi:10.1093/humrep/den029 · Cited by 54
Gugliucci, A., Hermo, R., Monroy, C., et al. (2005) · Clinica Chimica Acta · doi:10.1016/j.cccn.2005.06.014 · Cited by 49
Cited by
Hypoalbuminemia: Pathogenesis and Clinical Significance
Soeters, P. B., Wolfe, R. R., & Shenkin, A. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1451 · Cited by 1,448
Metadata
- Authors
- GUVEN, S., ALVER, A., MENTESE, A., ILHAN, F. C., CALAPOGLU, M., & UNSAL, M. A.
- Affiliations
- Karadeniz Technical University (TR)
- Venue
- Acta Obstetricia et Gynecologica Scandinavica
- Publisher
- Wiley
- Published
- 2009-04
- Volume
- 88
- Issue
- 4
- Pages
- 479-482
- ISSN
- 0001-6349 (ISSN-L)
- 1600-0412
- OpenAlex
- W2021736148
- Cited by
- 47
- References
- 13
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 3
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Acta Obstetricia Et Gynecologica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Çanakkale Onsekiz Mart University AVESIS (submittedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Keywords
- ischemia-modified albumin, pregnancy, oxidative stress, malondialdehyde, serum albumin, physiological changes in pregnancy, maternal serum biomarkers
- MeSH terms
- Adult, Cross-Sectional Studies, Female, Gestational Age, Humans, Ischemia, Malondialdehyde, Pregnancy, Prospective Studies, Serum Albumin, Biomarkers, Case-Control Studies, Oxidative Stress
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
