The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Gentamicin release from polymethylmethacrylate bone cements and Staphylococcus aureus biofilm formation
Open accessAbstract
We measured the formation of a Staphylococcus aureus biofilm in vitro on unloaded and gentamicin-loaded bone cements (CMW3 and Palacos R) and related the formation to antibiotic release rates. All experiments were done in triplicate. Microbial growth on gentamicin-loaded cements occurred despite the release of antibiotic. Biofilm formation on gentamicin loaded CMW3 bone cement was one fourth to one fifth less than on the unloaded bone cement, while biofilm formation on Palacos R bone cement was not significantly affected by antibiotic loading. More gentamicin was released from CMW3 (79 mg) than from Palacos R (70 mg), but the percentage gentamicin released after one week relative to the total amount incorporated was significantly lower for CMW3 (4.7%) than for Palacos R (8.4%). After one day, subinhibitory concentrations of antibiotics were eluted from the cements. We concluded that antibiotic-loaded bone cement does not necessarily inhibit the formation of an infectious biofilm in vitro.
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Citations
Cites
Release of gentamicin from acrylic bone cement
Bunetel, L., Segui, A., Cormier, M., Percheron, E., & Langlais, F. (1989) · Clinical Pharmacokinetics · doi:10.2165/00003088-198917040-00006 · Cited by 123
van de Belt, H., Neut, D., van Horn, J. R., van der Mei, H. C., Schenk, W., & Busscher, H. J. (1999) · Nature Medicine · doi:10.1038/7330 · Cited by 55
Self-citation
Cited by
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Linklater, D. P., Baulin, V. A., Juodkazis, S., Crawford, R. J., Stoodley, P., & Ivanova, E. P. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0414-z · Cited by 578
Masters, E. A., Trombetta, R. P., de Mesy Bentley, K. L., Boyce, B. F., Gill, A. L., Gill, S. R., Nishitani, K., Ishikawa, M., Morita, Y., Ito, H., et al. (2019) · Bone Research · doi:10.1038/s41413-019-0061-z · Cited by 575
Infection after fracture fixation: Current surgical and microbiological concepts
Metsemakers, W. J., Kuehl, R., Moriarty, T. F., Richards, R. G., Verhofstad, M. H. J., Borens, O., Kates, S., & Morgenstern, M. (2018) · Injury · doi:10.1016/j.injury.2016.09.019 · Cited by 544
ANTIBIOTIC-LOADED BONE CEMENT FOR INFECTION PROPHYLAXIS IN TOTAL JOINT REPLACEMENT
JIRANEK, W. A., HANSSEN, A. D., & GREENWALD, A. S. (2006) · The Journal of Bone and Joint Surgery-American Volume · doi:10.2106/00004623-200611000-00024 · Cited by 411
Campoccia, D., Montanaro, L., Speziale, P., & Arciola, C. R. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.005 · Cited by 392
Metadata
- Authors
- Belt, H. V. D., Neut, D., Schenk, W., Horn, J. R. V., Mei, H. C. V. D., & Busscher, H. J.
- Venue
- Acta Orthopaedica Scandinavica
- Published
- 2000-01
- Volume
- 71
- Issue
- 6
- Pages
- 625-629
- ISSN
- 0001-6470 (ISSN-L)
- OpenAlex
- W2164766448
- Cited by
- 168
- References
- 2
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Belt, H. V. D., Neut, D., Schenk, W., Horn, J. R. V., Mei, H. C. V. D., & Busscher, H. J. (2000). Gentamicin release from polymethylmethacrylate bone cements and Staphylococcus aureus biofilm formation. Acta Orthopaedica Scandinavica. https://doi.org/10.1080/000164700317362280
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