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Cited by 9Parasitic Diseases Research and TreatmentParasites and Host InteractionsResearch on Leishmaniasis Studies

The DOI matches its Crossref record; 7 of the 8 references it cites were found in a registry or an index, and 1 are not checked yet.

Research notes from the Onchocerciasis Chemotherapy Research Centre, Ghana

Awadzi, K.·1997·Annals of Tropical Medicine & Parasitology
DOI 10.1080/00034983.1997.11813193
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Abstract

Brief notes are given on drugs which have been tested at the Onchocerciasis Chemotherapy Research Centre at Tamale and Hohoe and found to have activity against Onchocerca volvulus.Ivermectin in single doses as high as 800 µg/kg was found to be no more effective than the standard dose of 150 µg/kg. The benzimidazole carbamates, mebendazole and albendazole, differ in their effects on O. volvulus. The former has microfilaricidal effects and is toxic to developing embryos surrounded by an egg shell but not the stretched microfilariae. Albendazole has no microfilaricidal activity but is toxic to all intra-uterine stages. The reasons for these differences are unclear. Early studies with amocarzine are described; the maximum tolerable dose is 20 mg/kg and the predominant activity, against the microfilariae, is marked only at doses greater than 12 mg/kg. None of the drugs tested has macrofilaricidal activity.

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Crossref · 10.1080/00034983.1997.11813193

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Research works printed but not linked: 5

  1. Awadzi, K., Hero, M., Opoku, N. O., Büttner, D. W. & Gilles, H. M. (1991). The chemotherapy of onchocerciasis. XV. Studies with albendazole. Tropical Medicine and Parasitology, 42, 356–360.
  2. Awadzi, K., Opoku, N. O., Büttner, D. W., Coventry, P. A., Prime, M. A., Orme, M. L. E. & Edwards, G. (1994) The chemotherapy of onchocerciasis. XVII. A clinical evaluation of albendazole in patients with onchocerciasis: effects of food and pretreatment with ivermectin on drug response and pharmacokinetics. Tropical Medicine and Parasitology, 45, 203–208.
  3. Awadzi, K., Addy, E. T., Opoku, N. O., Plenge-Bönig, A. & Büttner, D. W. (1995b). The chemotherapy of onchocerciasis. XX. Ivermectin in combination with albendazole. Tropical Medicine and Parasitology, 46, 213–220.
  4. Taylor, H. R., Awadzi, K., George, T., Schulz-Key, H. & Murphy, R. P. (1985). Fluorescein angiographic studies of mebendazole treatment for onchocerciasis. Tropical Medicine and Parasitology, 36, 7–11.
  5. World Health Organization (1987). WHO Expert Committee on Onchocerciasis: Third Report. Technical Report Series No. 752. Geneva: WHO.

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Metadata

Authors
Awadzi, K.
Affiliations
,
Corresponding author
Awadzi, K.
Venue
Annals of Tropical Medicine & Parasitology
Publisher
Informa UK Limited
Published
1997-10
Volume
91
Issue
7
Pages
703-711
ISSN
  • 0003-4983 (ISSN-L)
  • 1364-8594
DOI
10.1080/00034983.1997.11813193
OpenAlex
W4246716412
Cited by
2
References
7
Citations by year
2022: 1 · 2021: 1
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Locations
Annals of Tropical Medicine and Parasitology (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
Keywords
onchocerciasis, Onchocerca volvulus, ivermectin, mebendazole, albendazole, microfilaricidal activity, macrofilaricidal activity, benzimidazole carbamates, chemotherapy

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