Biochemical, Neuropsychological, and Neurological Abnormalities Following 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Exposure
Abstract
Presented herein are the results of follow-up examinations of 13 workers performed in 1996--30 yr following 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication in a herbicide production plant. In these workers, the current mean plasma level of 2,3,7,8-TCDD, measured by high-resolution gas chromatography/high-resolution mass spectrometry, was 256 pg/gm lipid (range = 14-760 pg/gm lipid). This mean value corresponded to an estimated concentration of approximately 5,000 pg/gm plasma fat that existed about 30 years ago. Such a mean plasma level indicates that this group was one of the most heavily exposed groups to 2,3,7,8-TCDD described in the literature. Patients with persistent chloracne had significantly higher plasma levels of 2,3,7,8-TCDD than persons without chloracne. A significant, positive correlation was found between plasma levels of 2,3,7,8-TCDD in 1996 and levels of cholesterol and plasma lipids that existed since 1974. During 1996, there was a significant positive correlation between 2,3,7,8-TCDD and levels of beta-lipoproteins, cholesterol, and triglycerides. Also in 1996, significant correlations were found between neuropsychological variables and plasma levels of 2,3,7,8-TCDD. Other significant correlations were observed between neuropsychological variables and (1) the highest levels of triglycerides (i.e., since the year 1989), (2) levels of triglycerides in 1996, (3) levels of cholesterol at the first examination (i.e., 1969-1970), (4) highest level of cho…
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In workers occupationally exposed to TCDD, neurological and neurophysiological abnormalities were detected even decades after exposure.
“In workers occupationally exposed to TCDD, neurological and neurophysiological abnormalities were detected even decades after exposure, suggesting that the functional consequences of these pollutants may be exceptionally long-lasting (Pelclova et al., 2018; Pelclová et al., 2001).”
From Environmental endocrine disruptors at the synapse: mechanisms linking chemical exposure to cognitive and behavioral dysfunction (2026) · cites this paper as Pelclová et al., 2001
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Jocsak, G., Kiss, D. S., Alymbaeva, D., Diebald, A., Zsarnovszky, A., Heinzlmann, A., & Bartha, T. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1821381 · Cited by 1 · see citing works
“In workers occupationally exposed to TCDD, neurological and neurophysiological abnormalities were detected even decades after exposure, suggesting that the functional consequences of these pollutants may be exceptionally long-lasting (Pelclova et al., 2018; Pelclová et al., 2001).”
- Authors
- Pelclová, D., Fenclová, Z., Dlasková, Z., Urban, P., Lukáš, E., Procházka, B., Rappe, C., Preiss, J., Koč, A., & Vejlupková, J.
- Affiliations
- Charles University (CZ)
- National Institute of Public Health (CZ)
- Na Homolce Hospital (CZ)
- Venue
- Archives of Environmental Health: An International Journal
- Publisher
- Informa UK Limited
- Published
- 2001-11
- Volume
- 56
- Issue
- 6
- Pages
- 493-500
- ISSN
- 0003-9896 (ISSN-L)
- OpenAlex
- W2002840463
- Cited by
- 34
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 3
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Environmental Health An International Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Keywords
- 2,3,7,8-tetrachlorodibenzo-p-dioxin, chloracne, long-term follow-up, plasma lipids, cholesterol, triglycerides, low-density lipoprotein, neuropsychological performance, memory impairment, electroencephalography abnormalities, visual evoked potentials, electromyography abnormalities
- MeSH terms
- Polychlorinated Dibenzodioxins, Mental Disorders, Chemical Industry, Chromatography, Gas, Czechoslovakia, Data Interpretation, Statistical, Electroencephalography, Electromyography, Follow-Up Studies, Humans, Lipids, Liver Function Tests, Male, Middle Aged, Nervous System Diseases, Neurologic Examination, Neuropsychological Tests, Occupational Diseases, Occupations, Mass Spectrometry, Time Factors, Lipid Metabolism
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