Chlorinated hydrocarbon insecticides in organs of stillborn and blood of newborn babies
Abstract
The chlorinated hydrocarbon insecticides DDT, its metabolites, and analogues; α-, β-, and γ-BHC (lindane); heptachlor epoxide; and dieldrin were determined by gas chromatography in adipose tissue, liver, adrenals, lungs, heart, brain, kidneys, and spleen of ten human infants, eight of whom were stillborn and two who died soon after birth. Samples of spinal cord and pancreas from three of the stillborn fetuses were also analyzed. In a separate study, samples of cord blood of 30 normal term babies were analyzed for the same compounds. Wide ranges were observed in the concentrations of the insecticides present in the various tissues and the cord blood, and not all compounds could be detected in each sample. The results obtained from the analysis of the tissues and cord btood fell within the ranges of the concentrations that have been found in various tissues and blood of the general adult population.
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Most reported studies have focused on persistent chemicals.
“Most of the reported studies have focused on persistent chemicals, presumably because they are easier to measure in tissue samples (Table 1) (Bjorvang et al., 2021; Mamsen et al., 2017, 2019; Curley et al., 1969; Doucet et al., 2009; Nishimura et al., 1977; Pusiol et al., 2016; Rawn et al., 2014; Schecter et al., 2007; Zavon et al., 1969).”
From Pregnancy-related maternal physiological adaptations and fetal chemical exposure (2023) · cites this paper as Curley et al., 1969
DDT, its metabolites, and other similar chlorinated lipophilic chemicals such as polychlorinated biphenyl ethers were found in multiple tissues of fetuses that died in the womb.
“DDT, its metabolites, and other similar chlorinated lipophilic chemicals such as polychlorinated biphenyl ethers, were found in multiple tissues of fe tuses that died in the womb (Curley et al., 1969; Nishimura et al., 1977; Zavon et al., 1969).”
From Pregnancy-related maternal physiological adaptations and fetal chemical exposure (2023) · cites this paper as Curley et al., 1969
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Pregnancy-related maternal physiological adaptations and fetal chemical exposure
Vinnars, M.-T., Bixo, M., & Damdimopoulou, P. (2023) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2023.112064 · Cited by 32 · see citing works
- Authors
- Curley, A., Copeland, M. F., & Kimbrough, R. D.
- Affiliations
- United States Food and Drug Administration (US)
- ORCID
- Copeland, M. Frank
- Venue
- Archives of Environmental Health: An International Journal
- Publisher
- Informa UK Limited
- Published
- 1969-11
- Volume
- 19
- Issue
- 5
- Pages
- 628-632
- ISSN
- 0003-9896 (ISSN-L)
- OpenAlex
- W2224165087
- Cited by
- 71
- References
- 0
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2014: 1 · 2013: 1
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Environmental Health An International Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
- Life Sciences › Agricultural and Biological Sciences › Food Science › Pesticide Residue Analysis and Safety
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- organochlorine insecticides, DDT, DDT metabolites, lindane, heptachlor epoxide, dieldrin, stillbirth, neonates, umbilical cord blood, tissue distribution, adipose tissue, fetal tissue
- MeSH terms
- Adipose Tissue, Adrenal Glands, Autopsy, Hexachlorocyclohexane, Blood, Brain Chemistry, Bridged-Ring Compounds, Chlorine, Chromatography, Gas, DDT, Dieldrin, Female, Fetal Death, Humans, Hydrocarbons, Halogenated, Indenes, Infant, Newborn, Insecticides, Kidney, Liver, Lung, Male, Maternal-Fetal Exchange, Myocardium, Pancreas, Pregnancy, Spinal Cord, Spleen, Umbilical Cord
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