The test-retest reliability of a standardized neurocognitive and neurophysiological test battery: “neuromarker”
Abstract
NeuroMarker combines EEG and ERP measures with neurocognitive tests in a fully computerized and standardized testing system. It is designed for use across the lifespan and has a large normative database of over 1,000 subjects. This study was a preliminary evaluation of "NeuroMarker" in subjects spanning four decades. Twenty-one healthy subjects (12-57 years) were tested at baseline and four weeks later. From the "Neuromarker" battery, the authors analyzed EEG data (eyes open and closed) and ERPs elicited during auditory oddball (N100, P200, N200, P300) and working memory (P150, P300) tasks. Concomitant neuropsychological data, acquired using a touch-screen system, comprised measures of sensori-motor, attention, verbal, executive, and memory function. Test-retest data were examined using analyses of variance and correlational procedures (corrected for multiple comparisons), with parallel analyses of age. EEG data did not differ across sessions, and showed high test-retest reliability (.71-.95), particularly for theta and delta (>.85). ERP components also showed sound reliability, particularly for sites where components are maximal: fronto-central N100 (.76-.77), centro-parietal P300 (.78-.81) to oddball targets, N100 and P200 (.74-.86) to oddball non-targets, and P150 amplitude and latency (.84-.93) to working memory stimuli. Neuropsychological tests showed a similarly sound level of consistency (on average, .70), with the most consistent tests tapping simple motor function, estimated intelligence, switching of attention (Part 2), verbal interference response time and memory intrusions (.71-.89). Age and sex did not have a differential impact on reliability for EEG, ERP, or neuropsychology measures. These findings provide preliminary evidence that the "NeuroMarker" battery is reliable for test-retest assessments. The results suggest that the standardized approach has utility for providing sensitive clinical and treatment evaluations across age groups.
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The Integneuro cognitive test battery has excellent psychometric properties and is sensitive to the effects of obesity.
“It has excellent psychometric properties18,19 and has been shown to be sensitive to the effects of obesity in past work.20”
From Cognitive Function After Bariatric Surgery: Evidence for Improvement 3 Years After Surgery (2014) · cites this paper as [19]
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References 52 · Cited by 293
- Authors
- WILLIAMS, L. M., SIMMS, E., CLARK, C. R., PAUL, R. H., ROWE, D., & GORDON, E.
- Affiliations
- Westmead Hospital (AU)
- The University of Sydney (AU)
- Flinders University (AU)
- Brown University (US)
- Venue
- International Journal of Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2005-01
- Volume
- 115
- Issue
- 12
- Pages
- 1605-1630
- ISSN
- 0020-7454 (ISSN-L)
- 1543-5245
- OpenAlex
- W2118423946
- Cited by
- 293
- References
- 52
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 13 · 2023: 13 · 2022: 9 · 2021: 14 · 2020: 12 · 2019: 12 · 2018: 21 · 2017: 10 · 2016: 17 · 2015: 20 · 2014: 21 · 2013: 17 · 2012: 16
- FWCI
- 8.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Flinders Academic Commons (Flinders University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Social Sciences › Psychology › Applied Psychology › Psychological Testing and Assessment
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- neuromarkers, test-retest reliability, EEG, event-related potentials, auditory oddball paradigm, P300, N1 component, p150, working memory, neuropsychological assessment, standardized test battery, reference values, age differences, sex differences
- MeSH terms
- Adolescent, Adult, Attention, Electronic Data Processing, Brain, Child, Cognition, Electroencephalography, Eye Abnormalities, Female, Humans, Male, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Problem Solving, Psychomotor Performance, Statistics as Topic, Verbal Behavior, Reproducibility of Results, Evoked Potentials, Motor
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