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Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference values
Abstract
Protein parameters in CSF and serum have been studied in ninety-three reference subjects. CSF/S albumin ratio is proposed to be superior to CSF-protein or CSF-albumin as a test of the blood-brain barrier function, while IgG-index = (CSF/S IgG ratio)/(CSF/S albumin ratio) is superior to CSF IgG/protein ratio or CSF/albumin ratio for the demonstration of IgG elevation in CSF due to synthesis within CNS. The two quotients recommended correct for variations of albumin and IgG concentrations in serum. When the serum proteins are within reference range, the CSF protein concentrations are mainly regulated by the permeability of the blood-brain barrier, while the influence of S-albumin and S-IgG is only secondarily. The CSF/S albumin ratio is age dependent, while IgG-index is not. A proposed graphical presentation of CSF/S albumin and IgG-index may facilitate the interpretation of these parameters in routine clinical work.
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Cited by
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Dalmau, J., Gleichman, A. J., Hughes, E. G., Rossi, J. E., Peng, X., Lai, M., Dessain, S. K., Rosenfeld, M. R., Balice-Gordon, R., & Lynch, D. R. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70224-2 · Cited by 3,488
Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
Blennow, K., Hampel, H., Weiner, M., & Zetterberg, H. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.4 · Cited by 1,863
Perry, V. H., Hume, D. A., & Gordon, S. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90215-5 · Cited by 902
Blood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis
Farrall, A. J., & Wardlaw, J. M. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.07.015 · Cited by 882
Blennow, K., Wallin, A., Ågren, H., Spenger, C., Siegfried, J., & Vanmechelen, E. (1995) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815140 · Cited by 789
Metadata
- Authors
- Tibbling, G., Link, H., & Ohman, S.
- Venue
- Scandinavian Journal of Clinical and Laboratory Investigation
- Publisher
- Informa UK Limited
- Published
- 1977-09-01
- Volume
- 37
- Issue
- 5
- Pages
- 385-390
- ISSN
- 0036-5513 (ISSN-L)
- OpenAlex
- W2108020835
- Cited by
- 966
- References
- 0
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tibbling, G., Link, H., & Ohman, S. (1977). Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference values. Scandinavian Journal of Clinical and Laboratory Investigation. https://doi.org/10.1080/00365517709091496
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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