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Survival following the development of ascites and/or peripheral oedema in primary biliary cirrhosis: A staged prognostic model
Abstract
OBJECTIVE: Current prognostic models in primary biliary cirrhosis (PBC) have low precision, partly due to the restricted inclusion criteria of some cohorts used for modelling but also because of the prolonged natural course of the disease. It is hypothesized that better precision could be achieved with a staged model, using ascites or peripheral oedema as a new starting-point for prediction. MATERIAL AND METHODS: The study was based on an established database of 289 consecutive patients, followed between 1977 and 1998. Stepwise Cox regression was used to construct a staged model based on 143 patients who first developed ascites (n=111) or peripheral oedema (n=32) at entry or during subsequent follow-up. The model was compared with published models using graphical methods and receiver operating characteristics (ROCs). RESULTS: Mean time from clinical diagnosis of ascites or peripheral oedema to death was 3.1 years. The following variables had independent prognostic significance: log10(bilirubin) (p<0.001), albumin (p<0.001), age (p<0.001) and history of encephalopathy (p<0.001). Goodness of fit showed that the survival probabilities predicted by the Ascites Stage Model fitted well with the observed data. The Ascites Stage Model (ROC 0.8324 (SE 0.0348)) was a better predictor of survival than the Mayo long-term model (ROC 0.7833 (SE 0.0397)), the Mayo Repeated Patient Visits Model (ROC 0.7779 (SE 0.0399)) and the Royal Free PBC Prognostic Model (ROC 0.7785 (SE 0.0396)). CONCLUSIONS: The Ascites Stage Model gives a better survival estimate for PBC patients once they have developed ascites or peripheral oedema compared with the current models, and demonstrates an advantage of staged models in diseases with a prolonged natural history.
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“In 143 patients who first developed ascites or peripheral oedema, the mean time to death was 3.1 years.131”
From The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines (2018) · cites this paper as [131]
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Metadata
- Authors
- Chan, C.-W., Carpenter, J. R., Rigamonti, C., Gunsar, F., & Burroughs, A. K.
- Affiliations
- The Royal Free Hospital (GB)
- London School of Hygiene & Tropical Medicine (GB)
- Royal Free London NHS Foundation Trust (GB)
- Corresponding author
- Burroughs, Andrew K.
- Venue
- Scandinavian Journal of Gastroenterology
- Publisher
- Informa UK Limited
- Published
- 2005-01
- Volume
- 40
- Issue
- 9
- Pages
- 1081-1089
- ISSN
- 0036-5521 (ISSN-L)
- 1502-7708
- OpenAlex
- W2148674881
- Cited by
- 17
- References
- 21
- Citations by year
- 2026: 1 · 2020: 1 · 2018: 4 · 2017: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Economic and Social Research Council
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
- Keywords
- primary biliary cirrhosis, ascites, peripheral edema, survival prediction, prognostic model, bilirubin, serum albumin, encephalopathy
- MeSH terms
- Ascites, Edema, Female, Follow-Up Studies, Humans, Liver Cirrhosis, Biliary, Male, Middle Aged, Prognosis, Retrospective Studies, Severity of Illness Index, Time Factors, Survival Rate, Proportional Hazards Models, Disease Progression
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