The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Radiofrequency ablation versus ethanol injection for early hepatocellular carcinoma: A randomized controlled trial
Abstract
OBJECTIVE: To compare percutaneous ethanol injection (PEI), the standard approach which has been used for many years to treat early non-surgical hepatocellular carcinoma (HCC) in cirrhotic patients, and radiofrequency ablation (RFA), which has become an interesting alternative. MATERIAL AND METHODS: A randomized trial was carried out on 139 cirrhotic patients in Child-Pugh classes A/B with 1-3 nodes of HCC (diameter 15-30 mm), for a total of 177 lesions. Patients were randomized to receive RFA (n=70) or PEI (n=69). The primary end-point was complete response (CR) 1 year after the percutaneous ablation of all HCC nodes identified at baseline. Secondary end-points were: early (30-50 days) CR, complications, survival and costs. RESULTS: In an intention-to-treat analysis, 1-year CR was achieved in 46/70 (65.7%) and in 25/69 (36.2%) patients treated by RFA and PEI, respectively (p=0.0005). For lesions >20 mm in diameter, there was a larger CR rate in the RFA group (68.1% versus 26.3%). An early CR was obtained in 67/70 (95.7%) patients treated by RFA compared with 42/64 (65.6%) patients treated by PEI (p=0.0001). Complications occurred in 10 and 12 patients treated by RFA and PEI, respectively. The overall survival rate was not significantly different in the RFA versus PEI arm (adjusted hazard ratio=0.88, 95% CI: 0.50-1.53). There was an incremental health-care cost of 8286 euro for each additional patient successfully treated by RFA. CONCLUSIONS: The 1-year CR rate after percutaneous treatment of early HCC was significantly better with RFA than with PEI but did not provide a clear survival advantage in cirrhotic patients.
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Cites
Management of Hepatocellular Carcinoma *
Bruix, J., & Sherman, M. (2005) · Hepatology · doi:10.1002/hep.20933 · Cited by 5,857
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Prognosis of Hepatocellular Carcinoma: The BCLC Staging Classification
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Livraghi, T., Solbiati, L., Meloni, M. F., Gazelle, G. S., Halpern, E. F., & Goldberg, S. N. (2003) · Radiology · doi:10.1148/radiol.2262012198 · Cited by 1,298
Small Hepatocellular Carcinoma: Treatment with Radio-frequency Ablation versus Ethanol Injection
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Hepatocellular Carcinoma: Radio-frequency Ablation of Medium and Large Lesions
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Cited by
EASL–EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma
European Association for the Study of the Liver, & European Organisation for Research and Treatment of Cancer (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.12.001 · Cited by 5,218
“In one analysis including 13 studies (9 small RCT) there was a significant improvement in recurrence-free survival with interferon (estimated 3-year RFS of 54% versus 30% of placebo) [200].”
BackgroundInfluentialLocoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma
Llovet, J. M., De Baere, T., Kulik, L., Haber, P. K., Greten, T. F., Meyer, T., & Lencioni, R. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00395-0 · Cited by 1,044
Multimodal treatment of hepatocellular carcinoma on cirrhosis: An update
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Korean Liver Cancer Association, K., & National Cancer Center, N. (2019) · Gut and Liver · doi:10.5009/gnl19024 · Cited by 391
Germani, G., Pleguezuelo, M., Gurusamy, K., Meyer, T., Isgrò, G., & Burroughs, A. K. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2009.12.004 · Cited by 304
Metadata
- Authors
- Brunello, F., Veltri, A., Carucci, P., Pagano, E., Ciccone, G., Moretto, P., Sacchetto, P., Gandini, G., & Rizzetto, M.
- Venue
- Scandinavian Journal of Gastroenterology
- Publisher
- Informa UK Limited
- Published
- 2008-01
- Volume
- 43
- Issue
- 6
- Pages
- 727-735
- ISSN
- 0036-5521 (ISSN-L)
- 1502-7708
- OpenAlex
- W1999426782
- Cited by
- 302
- References
- 22
- FWCI
- 14.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brunello, F., Veltri, A., Carucci, P., Pagano, E., Ciccone, G., Moretto, P., Sacchetto, P., Gandini, G., & Rizzetto, M. (2008). Radiofrequency ablation versus ethanol injection for early hepatocellular carcinoma: A randomized controlled trial. Scandinavian Journal of Gastroenterology. https://doi.org/10.1080/00365520701885481
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