Pancreatic Glucagon Response to an Ordinary Meal
Abstract
Glucagon concentrations in the portal and peripheral venous blood were measured in 3 patients after an ordinary meal. A brief increase in glucagon concentration was found in the portal blood but not in the peripheral blood. As the glucose concentrations rose, the glucagon levels fell. The secretion of pancreatic glucagon therefore seems to depend largely on the blood glucose level.
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Because the normal hepatic portal-to-peripheral venous insulin concentration ratio is ~2.5:1.0, the mild peripheral hyperinsulinemia during somatostatin with insulin likely produced portal hypoinsulinemia.
“Since the normal hepatic portal-to-peripheral venous insulin concentration ratio is ~2.5:1.0 (29–32), this mild peripheral hyper-nsn n s s sn ns linemia.”
From Epinephrine supports the postabsorptive plasma glucose concentration and prevents hypoglycemia when glucagon secretion is deficient in man (1984) · cites this paper as [30]
The portal venous to peripheral venous plasma glucagon ratio is approximately 1.5:1 in humans.
“The portal venous to peripheral venous plasma glucagon ratio is ~1.5:1 in humans (14-16)”
The hepatic portal venous to peripheral venous insulin ratio is normally approximately 2.5:1.
“since the hepatic portal venous to peripheral venous insulin ratio is normally ~2.5:1 (14-16)”
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References 19 · Cited by 35
- Authors
- Dencker, H., Hedner, P., Holst, J., & Tranberg, K.-G.
- Affiliations
- Lund University (SE)
- Venue
- Scandinavian Journal of Gastroenterology
- Publisher
- Informa UK Limited
- Published
- 1975-08-01
- Volume
- 10
- Issue
- 5
- Pages
- 471-474
- ISSN
- 0036-5521 (ISSN-L)
- 1502-7708
- OpenAlex
- W2419149886
- Cited by
- 35
- References
- 19
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Keywords
- pancreatic glucagon, portal blood, peripheral venous blood, blood glucose, postprandial hormone response
- MeSH terms
- Insulin Secretion, Blood Glucose, Fasting, Female, Food, Glucagon, Humans, Insulin, Male, Middle Aged, Pancreas, Time Factors
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