The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Effects of Lactulose and Lactitol on Colonic Microflora and Enzymatic Activity
Abstract
The effects of lactulose and lactitol (2 x 10 g/d) were studied in 36 healthy volunteers in comparison to placebo. All parameters studied were affected by both treatments, lactulose in general leading to more pronounced changes compared to lactitol. Probiotic bacteria were increased, and putrefactive bacteria and potential pathogens were significantly reduced. These variations in colonic flora had the following consequences: (i) a reduced activity of pro-carcinogenic enzymes: azoreductase, 7 alpha-dehydroxylase, beta-glucuronidase, nitroreductase and urease activity; (ii) a global increase of short-chain fatty acids in faeces; (iii) an effect on pH and moisture of faeces, and (iv) also on aromatic compounds such as phenol, cresol, indole and skatol. The findings suggest that lactulose and lactitol are not comparable in their effect on the colonic microflora, its metabolism, and the consequent probiotic effects on human health. The differences found may also be of clinical relevance suggesting that neither compound is equipotent.
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Cites
Effect of Diet and Lactobacillus acidophilus Supplements on Human Fecal Bacterial Enzymes23
Goldin, B. R., Swenson, L., Dwyer, J., Sexton, M., & Gorbach, S. L. (1980) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/64.2.255 · Cited by 286
Cited by
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Guarner, F., & Malagelada, J.-R. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12489-0 · Cited by 3,365
Functional food science and gastrointestinal physiology and function
Salminen, S., Bouley, C., Boutron, M.-C., Cummings, J. H., Franck, A., Gibson, G. R., Isolauri, E., Moreau, M.-C., Roberfroid, M., & Rowland, I. (1998) · British Journal of Nutrition · doi:10.1079/bjn19980108 · Cited by 1,398
Relevance of protein fermentation to gut health
Windey, K., De Preter, V., & Verbeke, K. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100542 · Cited by 692
Protective role of probiotics and prebiotics in colon cancer
Wollowski, I., Rechkemmer, G., & Pool-Zobel, B. L. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.451s · Cited by 560
Effects of Sweeteners on the Gut Microbiota: A Review of Experimental Studies and Clinical Trials
Ruiz-Ojeda, F. J., Plaza-Díaz, J., Sáez-Lara, M. J., & Gil, A. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy037 · Cited by 426
Metadata
- Authors
- Ballongue, J., Schumann, C., & Quignon, P.
- Venue
- Scandinavian Journal of Gastroenterology
- Publisher
- Informa UK Limited
- Published
- 1997-01
- Volume
- 32
- Issue
- sup222
- Pages
- 41-44
- ISSN
- 0036-5521 (ISSN-L)
- 1502-7708
- OpenAlex
- W138260116
- Cited by
- 234
- References
- 1
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ballongue, J., Schumann, C., & Quignon, P. (1997). Effects of Lactulose and Lactitol on Colonic Microflora and Enzymatic Activity. Scandinavian Journal of Gastroenterology. https://doi.org/10.1080/00365521.1997.11720716
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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