Advances in the Chemical Synthesis of Artemisinin
Abstract
Artemisinin, existing in the Chinese medicinal plant Artemisia annua L., is a kind of sesquiterpenoid lactone endoperoxide. It has received extensive attention from all over the world owing to its unusual trioxane structure and potent antimalarial properties. Here we demonstrate the complete chemical synthetic pathway of artemisinin, investigated the past three decades, including the total and partial syntheses.
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Chemical synthesis of artemisinin remains costly despite recent advances and improved process design.
“Enhancement of artemisinin production in the whole plant is recommended because despite recent advances and improved process design (Sixt et al. 2018), chemical synthesis of artemisinin remains costly (Wang et al. 2014).”
From Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches (2021) · cites this paper as Wang et al. 2014
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References 45 · Cited by 35
- Authors
- Wang, Z., Yang, L., Yang, X., & Zhang, X.
- Affiliations
- Beijing University of Chinese Medicine (CN)
- China University of Petroleum, Beijing (CN)
- c School of Pharmaceutical Sciences , Peking University , Beijing , China
- Corresponding author
- Zhang, Xiaohua
- Venue
- Synthetic Communications
- Publisher
- Informa UK Limited
- Published
- 2014-06-09
- Volume
- 44
- Issue
- 14
- Pages
- 1987-2003
- ISSN
- 0039-7911 (ISSN-L)
- 1532-2432
- OpenAlex
- W2088870236
- Cited by
- 35
- References
- 45
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 7 · 2020: 5 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Synthetic Communications (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Physical Sciences › Chemistry › Organic Chemistry › Organic Chemistry Synthesis Methods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biological Activity of Diterpenoids and Biflavonoids
- Keywords
- artemisinin, total synthesis, semisynthesis, Artemisia annua, sesquiterpene lactones, endoperoxides, antimalarial drugs
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