The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man
Abstract
1. In the present study, nine cytochrome P450 enzyme activities in seven species were characterized to allow a practical means of comparing this important metabolic step between various test animals and man. 2. Enzyme activities and kinetic parameters were first determined towards marker substrates for human cytochrome P450 enzymes. Inhibition profiles were then determined with both antibodies directed against various cytochrome P450 enzymes and with chemical inhibitors. 3. Both the enzyme kinetic parameters/enzyme activities, and the inhibition profiles obtained for the animal species were compared with those obtained for human liver microsomes in order to postulate the animal species most similar to man with regard to each individual cytochrome P450 enzyme activity. 4. It was found that, as expected, none of the tested species was similar to man for all the measured P450 enzyme activities, but that in each species only some of the P450 enzyme activities could be considered as similar to man. 5. When it is known which human cytochrome P450 enzymes are involved in the metabolism of a compound, the comparative data presented here can be used for selecting the most suitable species for in vitro and in it no experiments.
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Cited by
Martignoni, M., Groothuis, G. M. M., & de Kanter, R. (2006) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2.6.875 · Cited by 1,478
Murine Models to Evaluate Novel and Conventional Therapeutic Strategies for Cancer
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The utility of the minipig as an animal model in regulatory toxicology
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Sjögren, E., Abrahamsson, B., Augustijns, P., Becker, D., Bolger, M. B., Brewster, M., Brouwers, J., Flanagan, T., Harwood, M., Heinen, C., et al. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.02.010 · Cited by 279
Comparison of minipig, dog, monkey and human drug metabolism and disposition
Dalgaard, L. (2015) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2014.12.005 · Cited by 132
Metadata
- Authors
- Bogaards, J. J. P., Bertrand, M., Jackson, P., Oudshoorn, M. J., Weaver, R. J., Van Bladeren, P. J., & Walther, B.
- Venue
- Xenobiotica
- Publisher
- Informa UK Limited
- Published
- 2000-01
- Volume
- 30
- Issue
- 12
- Pages
- 1131-1152
- ISSN
- 0049-8254 (ISSN-L)
- 1366-5928
- OpenAlex
- W2098547087
- Cited by
- 368
- References
- 43
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bogaards, J. J. P., Bertrand, M., Jackson, P., Oudshoorn, M. J., Weaver, R. J., Van Bladeren, P. J., & Walther, B. (2000). Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man. Xenobiotica. https://doi.org/10.1080/00498250010021684
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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