Advancements in carboxymethyl cellulose (CMC) modifications and their diverse biomedical applications: A comprehensive review
Abstract
A Comprehensive Review delves into the evolution of carboxymethyl cellulose (CMC) modifications and their extensive utilization in biomedical fields. Various cross-linking agents and methods such as physical, chemical, photo, and enzymatic cross-linking are explored for enhancing CMC properties. This modified CMC exhibits notable antimicrobial and antifungal activities, rendering it pivotal in pharmaceutical formulations. Moreover, its versatility extends to biomedical applications including drug delivery, tissue engineering, wound dressing, regenerative medicine, bioimaging, biosensing, diagnosis, Vaccine and immunotherapy and other therapeutic purposes. This review provides a thorough insight into the multifaceted roles of modified CMC in contemporary biomedical sciences.
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Crosslinking strategies have been used to extend retention and reduce hydrogel expansion of CMC.
“Crosslinking strategies have been used to mitigate these issues by extending retention and reducing hydrogel expansion [139].”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [139]
Cites
Biodegradation of plastic polymers by fungi: a brief review
Srikanth, M., Sandeep, T. S. R. S., Sucharitha, K., & Godi, S. (2022) · Bioresources and Bioprocessing · doi:10.1186/s40643-022-00532-4 · Cited by 319 · see citing works
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Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering
Fazel Anvari-Yazdi, A., Badea, I., & Chen, X. (2025) · Gels · doi:10.3390/gels11060441 · Cited by 20 · see citing works
- Authors
- Kurhade, R. R., Shaikh, M. S., Nagulwar, V., & Kale, M. A.
- Affiliations
- Pharmaceutics, Government College of Pharmacy, Osmanpura, Aurangabad, Maharashtra
- Pharmaceutical Chemistry, Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus
- Pharmaceutical Chemistry, Government College of Pharmacy
- Government of Maharashtra (IN)
- Corresponding author
- Shaikh, Mohd Sayeed
- Kale, Mayura A.
- Venue
- International Journal of Polymeric Materials and Polymeric Biomaterials
- Publisher
- Informa UK Limited
- Published
- 2024-10-24
- Volume
- 74
- Issue
- 11
- Pages
- 1043-1067
- ISSN
- 0091-4037 (ISSN-L)
- 1563-535X
- OpenAlex
- W4403728763
- Cited by
- 55
- References
- 1
- Citations by year
- 2026: 29 · 2025: 25 · 2024: 1
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Polymeric Materials (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Advanced Cellulose Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- carboxymethyl cellulose, crosslinking agents, enzymatic crosslinking, photocrosslinking, crosslinking, physical crosslinking, antimicrobial activity, antifungal activity, drug delivery, tissue engineering, wound dressings, regenerative medicine, bioimaging, biosensing, vaccine delivery, immunotherapy
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