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EXTRAPULMONARY TRANSLOCATION OF ULTRAFINE CARBON PARTICLES FOLLOWING WHOLE-BODY INHALATION EXPOSURE OF RATS

Oberdörster, Günter, Sharp, Zachary, Atudorei, Viorel, Elder, Alison, Gelein, Robert, Lunts, Alex, Kreyling, Wolfgang, Cox, Christopher·2002·Journal of Toxicology and Environmental Health, Part A
DOI 10.1080/00984100290071658
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Abstract

Studies with intravenously injected ultrafine particles have shown that the liver is the major organ of their uptake from the blood circulation. Measuring translocation of inhaled ultrafine particles to extrapulmonary organs via the blood compartment is hampered by methodological difficulties (i.e., label may come off, partial solubilization) and analytical limitations (measurement of very small amounts). The objective of our pilot study was to determine whether ultrafine elemental carbon particles translocate to the liver and other extrapulmonary organs following inhalation as singlet particles by rats. We generated ultrafine (13)C particles as an aerosol with count median diameters (CMDs) of 20-29 nm (GSD 1.7) using electric spark discharge of (13)C graphite electrodes in argon. Nine Fischer 344 rats were exposed to these particles for 6 h. in whole-body inhalation chambers at concentrations of 180 and 80 microg/m(3); 3 animals each were killed at 0.5, 18, and 24 h postexposure. Six unexposed rats served as controls. Lung lobes, liver, heart, brain, olfactory bulb, and kidney were excised, homogenized, and freeze-dried for analysis of the added (13)C by isotope ratio mass spectrometry. Organic (13)C was not detected in the (13)C particles. The (13)C retained in the lung at 0.5 h postexposure was about 70% less than predicted by rat deposition models for ultrafine particles, and did not change significantly during the 24-h postexposure period. Normalized to exposure concentr…

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Metadata

Authors
Oberdörster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Lunts, A., Kreyling, W., & Cox, C.
Venue
Journal of Toxicology and Environmental Health, Part A
Publisher
Informa UK Limited
Published
2002-10-12
Volume
65
Issue
20
Pages
1531-1543
ISSN
  • 1528-7394
  • 1087-2620
DOI
10.1080/00984100290071658
Cited by
846
References
0
Language
en

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CoChat. (2026). Citation check: EXTRAPULMONARY TRANSLOCATION OF ULTRAFINE CARBON PARTICLES FOLLOWING WHOLE-BODY INHALATION EXPOSURE OF RATS. https://app.cochat.ai/papers/10.1080/00984100290071658
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Oberdörster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Lunts, A., Kreyling, W., & Cox, C. (2002). EXTRAPULMONARY TRANSLOCATION OF ULTRAFINE CARBON PARTICLES FOLLOWING WHOLE-BODY INHALATION EXPOSURE OF RATS. Journal of Toxicology and Environmental Health, Part A. https://doi.org/10.1080/00984100290071658