Anticardiolipin antibodies in Jamaican primiparae
Abstract
A prevalence survey of anticardiolipin antibodies (aCL) was done among 924 primiparae. aCL were measured in serum by the standardised anticardiolipin enzyme linked immunosorbent assays (ELISA) and beta(2)-glycoprotein 1 assays to determine the seroprevalence of both beta(2) glycoprotein 1 dependent aCL and beta(2)-glycoprotein 1 independent aCL in Jamaican primiparae, to determine whether aCL are associated with abnormal pregnancy outcomes and if treatment with aspirin had any effect on pregnancy outcome in aCL positive primiparae. The prevalence of aCL was (32/671) 4.8% (95%CI 3.2-6.4) in women who were tested twice. A total of 49 of 924 primiparae or 5.3% (95%CI 3.9-6.7) were positive for aCL on at least one occasion. Only three of the 32 primiparae 3/32 (9.4%) who were positive for aCL on two occasions were positive for beta(2)-glycoprotein 1 dependent aCL. Pregnancy outcome did not differ significantly with respect to aCL status. Aspirin therapy did not influence pregnancy outcome in the 49 aCL positive primiparae studied.
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Data from one placebo-controlled RCT in six women with SLE and three low-quality studies in women without SLE found no difference in live birth prevalence with LDA use.
“Data from one placebo-controlled RCT of LDA in six women with SLE42 and data from three low-quality studies (two RCTs, one retrospective cohort)43–45 of women without SLE found no difference in the prevalence of live births with use of LDA.”
From EULAR recommendations for the management of antiphospholipid syndrome in adults (2019) · cites this paper as [44]
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References 29 · Cited by 14
- Authors
- Kahwa, E. K., Sargeant, L. A., McCaw-Binns, A., McFarlane-Anderson, N., Smikle, M., Forrester, T., & Wilks, R.
- Affiliations
- Research Institute for Tropical Medicine (PH)
- University of the West Indies (JM)
- Corresponding author
- Kahwa, E. K.
- Venue
- Journal of Obstetrics and Gynaecology
- Publisher
- Informa UK Limited
- Published
- 2006-01
- Volume
- 26
- Issue
- 2
- Pages
- 122-126
- ISSN
- 0144-3615 (ISSN-L)
- 1364-6893
- OpenAlex
- W2082441416
- Cited by
- 14
- References
- 29
- Citations by year
- 2023: 2 · 2020: 3 · 2019: 7 · 2015: 1
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Obstetrics and Gynaecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- World Health Organization
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- anticardiolipin antibodies, beta2-glycoprotein I, primiparous women, seroprevalence, pregnancy outcomes, aspirin therapy, antiphospholipid antibodies, Jamaican women
- MeSH terms
- Adolescent, Adult, Aspirin, Female, Humans, Jamaica, Parity, Platelet Aggregation Inhibitors, Pregnancy, Pregnancy Outcome, Seroepidemiologic Studies, Antibodies, Anticardiolipin
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