Frontal lobe lesions, diffuse damage, and neuropsychological functioning in traumatic brain-injured patients
Abstract
This study quantified lesion volume in relation to damage location and executive functioning in traumatic brain-injured (TBI) patients. Magnetic resonance (MR) scans of 68 TBI patients were analyzed by taking volumetric measures of lesion sites. Patients were grouped according to the presence/absence of frontal lobe lesions. Measures of frontal lesion volume were studied as predictors for outcome on designated tests of executive functioning (Halstead Category Test and Wisconsin Card Sorting Test). Results showed no significant differences in level of deficit between groups. In addition, no significant differences were found between groups on other tests of neuropsychological functioning (Trail Making Test, Parts A and B, and Wechsler Adult Intelligence Scale-Revised). These results suggest that tests that are traditionally used to detect "frontal lobe" damage may not be adequate for distinguishing specific frontal lobe dysfunction, and do not add anything unique about frontal lobe integrity and neuropsychological functioning in TBI patients.
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Milner's finding of a specific dorsolateral prefrontal deficit on the Wisconsin Card Sorting Test has never been entirely replicated by Milner or any other investigator, although there are many failures to replicate.
“However this finding has never to our knowledge been entirely replicated, either by Milner or by any other investigator, although there are many failures to replicate (see, e.g., Anderson et al., 1995; Corcoran & Upton, 1993; van den Broek et al., 1993).”
From The case for the development and use of ecologically valid measures of executive function in experimental and clinical neuropsychology (2006) · cites this paper as Anderson et al., 1995
Cites
Arnett, P. A., Rao, S. M., Bernardin, L., Grafman, J., Yetkin, F. Z., & Lobeck, L. (1994) · Neurology · doi:10.1212/wnl.44.3_part_1.420 · Cited by 279 · see citing works
Pathobiology of traumatically induced axonal injury in animals and man
Povlishock, J. T. (1993) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(05)82738-6 · Cited by 236 · see citing works
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BURGESS, P. W., ALDERMAN, N., FORBES, C., COSTELLO, A., M-A.COATES, L., DAWSON, D. R., ANDERSON, N. D., GILBERT, S. J., DUMONTHEIL, I., & CHANNON, S. (2006) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617706060310 · Cited by 663 · see citing works
An fMRI study of the Trail Making Test
Zakzanis, K. K., Mraz, R., & Graham, S. J. (2005) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2005.03.013 · Cited by 408 · see citing works
Ozonoff, S., Cook, I., Coon, H., Dawson, G., Joseph, R. M., Klin, A., McMahon, W. M., Minshew, N., Munson, J. A., Pennington, B. F., et al. (2004) · Journal of Autism and Developmental Disorders · doi:10.1023/b:jadd.0000022605.81989.cc · Cited by 391 · see citing works
- Authors
- Anderson, C. V., Bigler, E. D., & Blatter, D. D.
- Affiliations
- Brigham Young University (US)
- ORCID
- Bigler, Erin D.
- Venue
- Journal of Clinical and Experimental Neuropsychology
- Publisher
- Informa UK Limited
- Published
- 1995-12
- Volume
- 17
- Issue
- 6
- Pages
- 900-908
- ISSN
- 0165-0475 (ISSN-L)
- 1380-3395
- 1744-411X
- OpenAlex
- W2076976327
- Cited by
- 136
- References
- 2
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 6 · 2016: 7 · 2015: 5 · 2014: 5 · 2013: 5 · 2012: 6
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical and Experimental Neuropsychology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- traumatic brain injury, frontal lobe lesions, executive function, lesion volume, diffuse brain damage, neuropsychological outcomes, Halstead Category Test, Wisconsin Card Sorting Test, Trail Making Test, WAIS-R, frontal lobe dysfunction
- MeSH terms
- Brain Damage, Chronic, Brain Injuries, Female, Frontal Lobe, Humans, Magnetic Resonance Imaging, Male, Psychiatric Status Rating Scales
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