Prenatal and lactation nicotine exposure affects morphology and function of brown adipose tissue in male rat offspring
Abstract
The aim of this study was to investigate the effects of prenatal and lactation nicotine exposure on the morphology and function of brown adipose tissue (BAT) in male rat offspring. We conducted a morphological assay and gene expression study of interscapular BAT (iBAT) in male rat offspring. The male offspring from nicotine-exposed dams exhibited higher body weight and iBAT weight. Hematoxylin and eosin staining and transmission electron microscopy showed that iBAT from nicotine-exposed male offspring presented a "whitening" phenotype characterized by lipid droplet accumulation and impaired mitochondria with a randomly oriented and fractured cristae. The expression of the iBAT structure and function-related genes all decreased in nicotine-exposed male offspring. These data indicate that prenatal and lactation nicotine exposure affects morphology and function of iBAT in male rat offspring.
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PNE male offspring had delayed glucose clearance and higher area under the curve in glucose and insulin tolerance tests at 26 weeks.
“When the male pups were tested at 26 weeks using the intraperitoneal glucose and insulin tolerance tests, they found that their glucose clearance was delayed and the area under the curve was higher for nicotine exposed offspring than the control group”
From Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits (2023) · cites this paper as [152]
PNE male pups did not consume more food than controls, but had increased levels of adipogenic and lipogenic genes, increased levels of leptin mRNA, and higher serum insulin and lipid tests.
“Although the PNE male pups did not consume more food than the controls, they had increased levels of adipogenic and lipogenic genes, increased levels of leptin mRNA, and higher serum insulin and lipid tests.”
From Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits (2023) · cites this paper as [152]
PNE increases the obesity susceptibility of adult male rats by altering early adipogenesis.
“indicating the PNE increases the obesity susceptibility of adult male rats by altering early adipogenesis [152].”
From Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits (2023) · cites this paper as [152]
PNE adult male rat offspring had increased inguinal subcutaneous fat mass and body weight and decreased average cell area of adipocytes.
“Another study found that PNE adult male rat offspring had an increased inguinal subcutaneous fat mass and body weight and a decreased average cell area of adipocytes [152].”
From Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits (2023) · cites this paper as [152]
Cites
Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
Lowell, B. B., S-Susulic, V., Hamann, A., Lawitts, J. A., Himms-Hagen, J., Boyer, B. B., Kozak, L. P., & Flier, J. S. (1993) · Nature · doi:10.1038/366740a0 · Cited by 1,075 · see citing works
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Wells, A. C., & Lotfipour, S. (2023) · Advances in Drug and Alcohol Research · doi:10.3389/adar.2023.11628 · Cited by 50 · see citing works
- Authors
- Fan, J., Ping, J., Zhang, W.-X., Rao, Y.-S., Liu, H.-X., Zhang, J., & Yan, Y.-E.
- Affiliations
- Wuhan University (CN)
- Corresponding author
- Fan, Jie
- Venue
- Ultrastructural Pathology
- Publisher
- Informa UK Limited
- Published
- 2016-09-02
- Volume
- 40
- Issue
- 5
- Pages
- 288-295
- ISSN
- 0191-3123 (ISSN-L)
- 1521-0758
- OpenAlex
- W2508722401
- Cited by
- 14
- References
- 1
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 5 · 2018: 1
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ultrastructural Pathology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (No.81270950, No.81570792)
- Large-scale Instrument And Equipment Sharing Foundation of Wuhan University (2014, 2015)
- Hubei Provincial Natural Science Foundation of China (2015CFB183)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- nicotine exposure, prenatal exposure, lactation, brown adipose tissue, interscapular brown adipose tissue, lipid droplet accumulation, mitochondrial dysfunction, mitochondrial cristae, gene expression, body weight, male offspring, maternal smoking
- MeSH terms
- Animals, Body Weight, Adipose Tissue, Brown, Disease Models, Animal, Female, Lactation, Male, Nicotine, Pregnancy, Prenatal Exposure Delayed Effects, Rats, Wistar, Maternal Exposure, Microscopy, Electron, Transmission, Rats, Transcriptome, Real-Time Polymerase Chain Reaction
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