The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Brain Inflammation and Alzheimer's-Like Pathology in Individuals Exposed to Severe Air Pollution
Abstract
Air pollution is a complex mixture of gases (e.g., ozone), particulate matter, and organic compounds present in outdoor and indoor air. Dogs exposed to severe air pollution exhibit chronic inflammation and acceleration of Alzheimer's-like pathology, suggesting that the brain is adversely affected by pollutants. We investigated whether residency in cities with high levels of air pollution is associated with human brain inflammation. Expression of cyclooxygenase-2 (COX2), an inflammatory mediator, and accumulation of the 42-amino acid form of β-amyloid (A β42), a cause of neuronal dysfunction, were measured in autopsy brain tissues of cognitively and neurologically intact lifelong residents of cities having low (n:9) or high (n:10) levels of air pollution. Genomic DNA apurinic/apyrimidinic sites, nuclear factor- κB activation and apolipoprotein E genotype were also evaluated. Residents of cities with severe air pollution had significantly higher COX2 expression in frontal cortex and hippocampus and greater neuronal and astrocytic accumulation of A β42 compared to residents in low air pollution cities. Increased COX2 expression and A β42 accumulation were also observed in the olfactory bulb. These findings suggest that exposure to severe airpollution is associated with brain inflammation and A β 42 accumulation, two causes of neuronal dysfunction that precede the appearance of neuritic plaques and neurofibrillary tangles, hallmarks of Alzheimer's disease.
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Cites
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Oxidative Damage Is the Earliest Event in Alzheimer Disease
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Intraneuronal Aβ42 Accumulation in Human Brain
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NF-κB in neuronal plasticity and neurodegenerative disorders
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Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho
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Intraneuronal Aβ-Amyloid Precedes Development of Amyloid Plaques in Down Syndrome
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Calderón-Garcidueñas, L., Solt, A. C., Henríquez-Roldán, C., Torres-Jardón, R., Nuse, B., Herritt, L., Villarreal-Calderón, R., Osnaya, N., Stone, I., García, R., et al. (2008) · Toxicologic Pathology · doi:10.1177/0192623307313011 · Cited by 937
Self-citationThe outdoor air pollution and brain health workshop
Block, M. L., Elder, A., Auten, R. L., Bilbo, S. D., Chen, H., Chen, J.-C., Cory-Slechta, D. A., Costa, D., Diaz-Sanchez, D., Dorman, D. C., et al. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2012.08.014 · Cited by 539
Metadata
- Authors
- Calderón-Garcidueñas, L., Reed, W., Maronpot, R. R., Henriquez-Roldán, C., Delgado-Chavez, R., Calderón-Garcidueñas, A., Dragustinovis, I., Franco-Lira, M., Aragón-Flores, M., Solt, A. C., Altenburg, M., Torres-Jardón, R., & Swenberg, J. A.
- Venue
- Toxicologic Pathology
- Publisher
- SAGE Publications
- Published
- 2004-10
- Volume
- 32
- Issue
- 6
- Pages
- 650-658
- ISSN
- 0192-6233 (ISSN-L)
- 1533-1601
- OpenAlex
- W2161576159
- Cited by
- 583
- References
- 8
- FWCI
- 6.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Brain Inflammation and Alzheimer's-Like Pathology in Individuals Exposed to Severe Air Pollution. https://app.cochat.ai/papers/10.1080/01926230490520232
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- Calderón-Garcidueñas, L., Reed, W., Maronpot, R. R., Henriquez-Roldán, C., Delgado-Chavez, R., Calderón-Garcidueñas, A., Dragustinovis, I., Franco-Lira, M., Aragón-Flores, M., Solt, A. C., Altenburg, M., Torres-Jardón, R., & Swenberg, J. A. (2004). Brain Inflammation and Alzheimer's-Like Pathology in Individuals Exposed to Severe Air Pollution. Toxicologic Pathology. https://doi.org/10.1080/01926230490520232
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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