The DOI matches its Crossref record.
Cellular effects of hyperthermia: relevance to the minimum dose for thermal damage
Open accessAbstract
The specific mechanism of cell killing by hyperthermia is unknown, but the high activation energy of cell killing and other responses to hyperthermia suggest that protein denaturation is the rate-limiting step. Protein denaturation can be directly monitored by differential scanning calorimetry and in general there is a good correlation between protein denaturation and cellular response. Approximately 5% denaturation is necessary for detectable killing. Protein denaturation leads to the aggregation of both denatured and native protein with multiple effects on cellular function.
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Cited by
Thermal tissue damage analysis for magnetothermal neuromodulation and lesion size minimization
Kosari, E., & Vafai, K. (2020) · Brain Multiphysics · doi:10.1016/j.brain.2020.100014 · Cited by 18
Metadata
- Authors
- Lepock, J. R.
- Venue
- International Journal of Hyperthermia
- Publisher
- Informa UK Limited
- Published
- 2003-01-01
- Volume
- 19
- Issue
- 3
- Pages
- 252-266
- ISSN
- 0265-6736 (ISSN-L)
- 1464-5157
- OpenAlex
- W2038379840
- Cited by
- 395
- References
- 0
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
